J. Desai

发表

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Shuxia Zhao, Leigh Zawel, Stephen Fawell, 2013, Cancer discovery.

Total synthesis of the antifungal cyclic depsipeptides Sch 57697 and aureobasidin A

A. Cooper, J. Desai, V. Girijavallabhan, 1996 .

Binding affinities and geometries of various metal ligands in peptide deformylase inhibitors.

P. Weber, T. Fischmann, A. Cooper, 2002, Biophysical chemistry.

Discovery of hydroxyaniline amides as selective Extracellular Regulated Kinase (Erk) inhibitors.

W. Windsor, A. Samatar, D. Carr, 2015, Bioorganic & medicinal chemistry letters.

Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.

T. Fischmann, K. Maloney, C. Garlisi, 2017, Bioorganic & medicinal chemistry letters.

A convenient degradation of polyoxin D to uracil polyoxin C: access to key intermediates and synthesis of antifungal α-aminoacyl derivatives of UPOC

D. Loebenberg, A. Cacciapuoti, A. Cooper, 1993 .

Aqueous Diels-Alder reactions of electron deficient 2-arylfurans: a highly stereoselective route to 2,2,5-trisubstituted tetrahydrofurans towards a novel class of orally active azole antifungals

J. Desai, V. Girijavallabhan, A. Ganguly, 1993 .

A general synthesis of thiazoles. Part 3. Comparative evaluation of different functionalised thioureas as precursors

J. Desai, S. Rajappa, R. Sreenivasan, 1979 .

Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, Sch 42538 and Sch 45012

D. Loebenberg, A. Cacciapuoti, J. Desai, 1994 .

Sch 51048, a novel broad-spectrum orally active antifungal agent: Synthesis and preliminary structure-activity profile

D. Loebenberg, W. Haiyan, A. Cacciapuoti, 1995 .

Sch 51048, a Novel Broad-Spectrum Orally Active Antifungal Agent: Synthesis and Preliminary Structure-Activity Profile.

D. Loebenberg, W. Haiyan, A. Cacciapuoti, 1995 .

Advances in the chemistry of novel broad-spectrum orally active azole antifungals: recent studies leading to the discovery of SCH 56592.

W. Haiyan, A. Cooper, J. Desai, 1997 .

Synthesis and Antifungal Properties of 14‐Aminomethyl‐Substituted Lanosterol Derivatives

D. Loebenberg, D. Feingold, A. Cooper, 1988, Annals of the New York Academy of Sciences.

Synthesis and Antifungal Properties of 14-Aminomethyl-Substituted Lanosterol Derivatives.

D. Loebenberg, D. Feingold, A. Cooper, 1989 .

New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents.

P. Kirschmeier, Ming Liu, A. Nomeir, 2014, Bioorganic & Medicinal Chemistry Letters.

Discovery of C-imidazole azaheptapyridine FPT inhibitors.

W. R. Bishop, P. Kirschmeier, R. Doll, 2010, Bioorganic & medicinal chemistry letters.

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.

W. R. Bishop, P. Kirschmeier, L. Wang, 1998, Journal of medicinal chemistry.

Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.

W. R. Bishop, P. Weber, P. Kirschmeier, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of (5,6‐Dihydro‐11H‐benzo[5,6]cyclohepta [1,2‐b]pyridin‐11‐ylidene)‐1‐piperidine‐N‐cyanoguanidine Derivatives (I) as Inhibitors of Ras Farnesyl Protein Transferase.

W. R. Bishop, P. Weber, P. Kirschmeier, 2002 .

MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.

K. Cox, P. Kirschmeier, R. Doll, 2018, ACS medicinal chemistry letters.

Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.

P. Kirschmeier, R. Doll, W. Windsor, 2018, Bioorganic & medicinal chemistry letters.