D. Witter

发表

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Shuxia Zhao, Leigh Zawel, Stephen Fawell, 2013, Cancer discovery.

Design of novel histone deacetylase inhibitors.

A. Kral, Karin M. Otte, Thomas A. Miller, 2007, Bioorganic & medicinal chemistry letters.

Biosynthesis of ML-236C and the hypocholesterolemic agents compactin by Penicillium aurantiogriseum and lovastatin by Aspergillus terreus: determination of the origin of carbon, hydrogen and oxygen atoms by 13C NMR spectrometry and observation of unusual labelling of acetate-derived oxygens by 18O2

Yaoquan Liu, J. Vederas, Y. Yoshizawa, 1996 .

Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).

Joshua Close, Sriram Tyagarajan, C. Kenific, 2008, Bioorganic & medicinal chemistry letters.

Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.

C. Kenific, Melissa Chenard, A. Kral, 2014, ACS medicinal chemistry letters.

Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).

J. Grimm, Melissa Chenard, A. Kral, 2009, Bioorganic & medicinal chemistry letters.

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors*

Scott A. Peterson, R. Mahley, A. Meyer-Franke, 2011, The Journal of Biological Chemistry.

Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).

Melissa Chenard, A. Kral, B. Haines, 2008, Bioorganic & medicinal chemistry letters.

Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor

Irena Ivanovska, C. Chiu, I. Kariv, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Estimation of Fraction Dissolved After Intratracheal Delivery of a Potent Janus Kinase Inhibitor, iJAK-001, with Low Solubility in Rat and Sheep: Impact of Preclinical PKPD on Inhaled Human Dose Projection.

Hongshi Yu, Hyun-Hee Lee, M. Salmon, 2019, Journal of aerosol medicine and pulmonary drug delivery.

Suppression of racemization in the carbonylation of amino acid-derived aryl triflates

J. Grimm, D. Witter, Kevin J. Wilson, 2007 .

Glucokinase-activating ureas.

M. Nawano, A. Castelhano, M. Fyfe, 2005, Bioorganic & medicinal chemistry letters.

Design and synthesis of SH3 domain binding ligands: modifications of the consensus sequence XPpXP.

J. Cambier, A. Castelhano, D. Witter, 1998, Bioorganic & medicinal chemistry letters.

Benzo[b]thiophene-based histone deacetylase inhibitors.

R. Mosley, Thomas A. Miller, J. Secrist, 2007, Bioorganic & medicinal chemistry letters.

Derives du benzothiophene

Karin M. Otte, Thomas A. Miller, J. Methot, 2006 .

Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue

A. R. Hutchinson, J. Vederas, J. Kennedy, 2000 .

A divergent approach to the synthesis of 3-substituted-2-pyrazolines: Suzuki cross-coupling of 3-sulfonyloxy-2-pyrazolines.

J. Grimm, D. Witter, Kevin J. Wilson, 2009, The Journal of organic chemistry.

A new strategy for the synthesis of benzylic sulfonamides: palladium-catalyzed arylation and sulfonamide metathesis.

J. Grimm, D. Witter, Alan B. Northrup, 2007, The Journal of organic chemistry.

Novel phosphido-bridged cations [M2(CO)8(.mu.-PPh2)]BF4 (M = iron, ruthenium): synthesis, reactivity, and x-ray structure of an isoelectronic and structural analog of Ru2(CO)9

N. Taylor, D. Witter, S. Maclaughlin, 1990 .

Suppression of Racemization in the Carbonylation of Amino Acid-Derived Aryl Triflates.

J. Grimm, D. Witter, Kevin J. Wilson, 2007 .

Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors.

M. Augustin, X. Fradera, A. Bass, 2019, Bioorganic & medicinal chemistry letters.

Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors.

Matthew L. Maddess, Y. Liu, X. Fradera, 2022, ACS medicinal chemistry letters.

Safety and activity of CLN-081 (TAS6417) in NSCLC with EGFR Exon 20 insertion mutations (Ins20).

M. Socinski, E. Smit, V. Lee, 2021, Journal of Clinical Oncology.

Histone deacetylase inhibitors.

Thomas A. Miller, D. Witter, David J Witter, 2003, Journal of medicinal chemistry.

Revision of the biosynthetic origin of oxygens in mevinolin (lovastatin), a hypocholesterolemic drug from Aspergillus terreus MF 4845

Yaoquan Liu, J. Vederas, Y. Yoshizawa, 1994 .

Putative Diels-Alder-Catalyzed Cyclization during the Biosynthesis of Lovastatin.

J. Vederas, D. Witter, 1996, The Journal of organic chemistry.

Aminosuberoyl hydroxamic acids (ASHAs): a potent new class of HDAC inhibitors.

V. Richon, Thomas A. Miller, J. Secrist, 2007, Bioorganic & medicinal chemistry letters.

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.

Ryan V. Quiroz, Daniel S Spellman, Haiyan Xu, 2021, Journal of medicinal chemistry.

Yeast geranylgeranyltransferase type-II: steady state kinetic studies of the recombinant enzyme.

C. Poulter, D. Witter, 1996, Biochemistry.

Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4-b]furan Nucleoside Analogues.

Ryan V. Quiroz, Hongming Li, D. Witter, 2021, The Journal of organic chemistry.

1345P Preliminary safety and activity of CLN-081 in NSCLC with EGFR exon 20 insertion mutations (Ins20)

L. Zawel, D. Witter, N. Tchekmedyian, 2020 .

Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1).

J. Grimm, A. Kral, A. Szewczak, 2008, Bioorganic & medicinal chemistry letters.

Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays.

E. Duzic, W. Chen, D. Webb, 1999, Bioorganic & medicinal chemistry letters.