D. Diaz

发表

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

Dolores Diaz, Jianping Yin, Michael Burkard, 2016, Journal of medicinal chemistry.

Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.

Kevin A Ford, D. Sutherlin, M. Merchant, 2013, Toxicology and applied pharmacology.

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

P. Bernardi, C. Krejsa, P. Bernardi, 2006, Archives of Toxicology.

Identifying human toxicity potential

D. Diaz, 2006 .

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice.

D. Danilenko, E. Choo, N. Ghilardi, 2016, Toxicology and applied pharmacology.

MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats

G. Cain, D. Dambach, N. La, 2017, Toxicologic pathology.

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Dolores Diaz, Jun Chen, Deepak Sampath, 2015, Science Translational Medicine.

Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential.

Dolores Diaz, J. Xu, D. Diaz, 2004, Chemico-biological interactions.

Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1

M. Merchant, J. Boggs, Ted Lau, 2016, Toxicologic pathology.

The Use of Genetically Modified Animals in Discovery Toxicology

D. Diaz, J. Maher, 2016 .

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window.

I. Aliagas, K. Hoeflich, Weiru Wang, 2016, Journal of medicinal chemistry.

Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors

Xingrong Liu, J. Lyssikatos, D. Dambach, 2015, Toxicology mechanisms and methods.

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

S. Krauss, M. Merchant, P. Polakis, 2013, Cancer research.

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.

W. Fairbrother, K. Amemiya, H. Wong, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor

Xiaohong Song, Z. Tao, P. Kovar, 2020, ACS medicinal chemistry letters.

Issue Investigation and Practices in Discovery Toxicology

Dolores Diaz, Dylan P. Hartley, Raymond Kemper, 2016 .

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid

Dolores Diaz, Deepak Sampath, Hirdesh Uppal, 2015, Toxicology mechanisms and methods.

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Dolores Diaz, Cleopatra Kozlowski, Donna M Dambach, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

In Vitro Skin Models and Their Predictability in Defining Normal and Disease Biology, Pharmacology, and Toxicity

D. Danilenko, D. Diaz, Gail D. Lewis Phillips, 2016, Toxicologic pathology.

Abstract DDT02-03: Discovery of GDC-0994, a potent and selective ERK1/2 inhibitor in early clinical development

S. Gould, M. Belvin, Peter Yin, 2014 .

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.

Dolores Diaz, Brian Dean, Donna M Dambach, 2013, Journal of pharmaceutical sciences.

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

G. Cain, Cleopatra Kozlowski, D. Dambach, 2012, Toxicological Sciences.

Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1

M. Merchant, J. Boggs, Ted Lau, 2016, Toxicologic pathology.

MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats

G. Cain, D. Dambach, N. La, 2017, Toxicologic pathology.