J. Gaudino

发表

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

Dolores Diaz, Jianping Yin, Michael Burkard, 2016, Journal of medicinal chemistry.

Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.

Kevin A Ford, D. Sutherlin, M. Merchant, 2013, Toxicology and applied pharmacology.

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.

J. Blake, J. Christensen, B. Brandhuber, 2018, ACS medicinal chemistry letters.

Kilogram‐Scale Asymmetric Ruthenium‐Catalyzed Hydrogenation of a Tetrasubstituted Fluoroenamide

D. Sutherlin, M. Reynolds, J. Gaudino, 2011 .

Chemo-enzymatic synthesis of a branching decasaccharide fragment of the capsular polysaccharide of type III group B Streptococcus

J. Paulson, J. Gaudino, H. Jennings, 1991 .

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer

J. Blake, J. Christensen, G. Vigers, 2020 .

Synthesis of spirolactams and spiropiperidines as CCR4 receptor antagonists

Aaron S. Anderson, E. Laird, D. Chantry, 2006 .

A general synthesis of 5-arylnicotinates

W. J. Thompson, J. Gaudino, W. Thompson, 1984 .

Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.

J. Blake, Jianping Yin, Weiru Wang, 2015, Journal of medicinal chemistry.

New approaches to enzyme regulators. Synthesis and enzymological activity of carbocyclic analogs of D-fructofuranose and D-fructofuranose-6-phosphate

C. Wilcox, J. Gaudino, 1986 .

A concise approach to enantiomerically pure carbocyclic ribose analogs. Synthesis of (4S,5R,6R,7R)-7-(hydroxymethyl)spiro[2.4]heptane-4,5,6-triol 7-O-(dihydrogen phosphate)

C. Wilcox, J. Gaudino, 1990 .

Acyclic Stereocontrol in Additions of Grignard Reagents to α-Alkoxyiminium Ions. A Stereoselective Approach to threo Amino Ethers

C. Wilcox, J. Gaudino, M. Nagai, 1992 .

Insight into the unusual reactions of stabilized phosphorus ylides with lactols. A specific intramolecular hydroxyl group effect leads to high z-selectivity.

T. H. Webb, C. Wilcox, J. Gaudino, 1989 .

A general approach to carbocyclic sugar analogs: preparation of a carbocyclic analog of beta-D-fructofuranose.

C. Wilcox, J. Gaudino, 1990, Carbohydrate research.

Solid phase synthesis of 1,4-benzodiazepine-2,5-diones

J. Mayer, J. Gaudino, D. M. Lenz, 1996 .

New Approaches to Enzyme Regulators. Synthesis and Enzymological Activity of Carbocyclic Analogues of D-Fructofuranose and D-Fructofuranose 6-Phosphate.

C. Wilcox, J. Gaudino, 1986 .

Ligand interactions with E-selectin. Identification of a new binding site for recognition of N-acyl aromatic glucosamine substituents of sialyl Lewis X.

B. Lou, J. Gaudino, S. Defrees, 1996, Journal of medicinal chemistry.

Synthesis of bioactive sialosides

Y. Ito, J. Gaudino, J. Paulson, 1993 .

Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists.

Aaron S. Anderson, E. Laird, D. Chantry, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of novel fluorescently labeled sphingomyelin derivatives useful for sphingomyelinase assay

J. Gaudino, P. Chan-Hui, C. Wright, 1997 .

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.

J. Blake, Jianping Yin, Weiru Wang, 2014, Bioorganic & medicinal chemistry letters.

Discovery and Development of GDC-0994: A Selective and Efficacious Small Molecule Inhibitor of ERK1/2

J. Blake, John G. Moffat, J. Gaudino, 2018 .

Solid phase synthesis of peptidomimetics

J. Mayer, B. Goodman, G. Beaton, 2002 .

Abstract DDT02-03: Discovery of GDC-0994, a potent and selective ERK1/2 inhibitor in early clinical development

S. Gould, M. Belvin, Peter Yin, 2014 .

SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy

Ashutosh Kumar Singh, A. Drilon, K. Ching, 2023, Cancer Discovery.

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.

G. Vigers, J. Gaudino, Jennifer N. Otten, 2020, Journal of medicinal chemistry.

Discovery of Potent and Selective Covalent Inhibitors of HER2WT and HER2YVMA.

C. E. Wise, J. Gaudino, E. Hicken, 2024, Journal of medicinal chemistry.

Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors

D. Sutherlin, Xingrong Liu, B. Liederer, 2012, Xenobiotica; the fate of foreign compounds in biological systems.