Linjing Ren

发表

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

Dolores Diaz, Jianping Yin, Michael Burkard, 2016, Journal of medicinal chemistry.

Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.

E. Laird, S. Gloor, G. Vigers, 2014, Bioorganic & medicinal chemistry letters.

The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase.

Tyler T. Risom, E. Laird, S. Gloor, 2012, Bioorganic & medicinal chemistry letters.

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

Chao‐Jun Li, Peng Liu, P. Liu, 2019, European Journal of Organic Chemistry.

Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties.

E. Laird, Y. Ran, G. Hatzivassiliou, 2012, Journal of medicinal chemistry.

Catalytic Asymmetric Hydrocarboxylation and Hydrohydroxymethylation. A Two-Step Approach to the Enantioselective Functionalization of Vinylarenes

C. Crudden, Linjing Ren, Austin C Chen, 1999 .

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.

E. Laird, B. Brandhuber, G. Vigers, 2011, Bioorganic & medicinal chemistry letters.

Non-oxime inhibitors of B-Raf(V600E) kinase.

E. Laird, B. Brandhuber, G. Vigers, 2011, Bioorganic & medicinal chemistry letters.

A Palladium-Catalyzed Decarboxylative Heck-Type Reaction of Disubstituted Vinylphosphonates in the Stereoselective Synthesis of Trisubstituted Vinylphosphonates

Chunyan He, Feng Chen, Linjing Ren, 2019, European Journal of Organic Chemistry.

Design and synthesis of novel pyridinium nitrate-bearing substituted anilines via one-pot tandem reactions

Linjing Ren, Yang Huijuan, Ren Yujie, 2017 .

Chiral bidentate N-heterocyclic carbene complexes of Rh and Pd

C. Crudden, Linjing Ren, A. Decken, 2004 .

Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.

J. Blake, Jianping Yin, Weiru Wang, 2015, Journal of medicinal chemistry.

Chemoselective reduction of aldehydes via a combination of NaBH4 and acetylacetone

Jia-Ning Dai, Linjing Ren, Chi-Sing Lee, 2019, New Journal of Chemistry.

Recent Advance in the Transition-Metal Free Coupling Reactions for the Construction of C-X Bonds Induced by Light

Linjing Ren, Yan Qian, Qiuli Yao, 2019, Chinese Journal of Organic Chemistry.

Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.

Tyler Risom, Zhaoyang Wen, Ignacio Aliagas, 2011, ACS medicinal chemistry letters.

First total synthesis of (+)-pentandranoic acid A

Linjing Ren, E. Piers, E. Piers*, 2012 .

Homologations of boronate esters: the first observation of sequential insertions

C. Crudden, Linjing Ren, 2000 .

Catalytic asymmetric carbon–carbon bond forming reactions: preparation of optically enriched 2-aryl propionic acids by a catalytic asymmetric hydroboration–homologation sequence†

C. Crudden, Linjing Ren, Austin C Chen, 1999 .

The Photoinduced Metal-Free Hydrotrifluoromethylation of Vinyl Phosphonates or Phosphine Oxides

Liang Zhao, Linjing Ren, Kexin Li, 2019 .

Rhodium Carbene Complexes: Highly Selective Catalysts for the Hydroformylation of Styrene Derivatives

C. Crudden, Linjing Ren, A. Decken, 2000 .

The Discovery of Furo[2,3‐c]pyridine‐Based Indanone Oximes as Potent and Selective B‐Raf Inhibitors.

Linjing Ren, 2011 .

Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase.

Zhaoyang Wen, Joachim Rudolph, E. Laird, 2013, Bioorganic & medicinal chemistry letters.

Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.

Ellen R. Laird, Tyler Risom, Zhaoyang Wen, 2011, Bioorganic & medicinal chemistry letters.

Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: rational design and kinase selectivity profile of cell potent type II inhibitors.

Tyler T. Risom, E. Laird, S. Gloor, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis and antifungal activity of amide and imine derivatives containing a kakuol moiety.

Linjing Ren, Dan Xu, Wenming Zhou, 2019, Bioorganic & medicinal chemistry letters.

Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties.

E. Laird, S. Gloor, Jonas Grina, 2012, Bioorganic & medicinal chemistry letters.

Abstract DDT02-03: Discovery of GDC-0994, a potent and selective ERK1/2 inhibitor in early clinical development

S. Gould, M. Belvin, Peter Yin, 2014 .