A. Leite

发表

Halogen atoms in the modern medicinal chemistry: hints for the drug design.

Marcelo Zaldini Hernandes, M. Hernandes, S. M. Cavalcanti, 2010, Current drug targets.

New 1,3-thiazole derivatives and their biological and ultrastructural effects on Trypanosoma cruzi.

R. S. Ferreira, A. C. da Silva, V. Pereira, 2016, European journal of medicinal chemistry.

Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi.

P. Torres, A. Leite, F. P. Silva Junior, 2016, Bioorganic & medicinal chemistry.

Chagas Disease Treatment and Rational Drug Discovery: A Challenge That Remains

M. C. Brelaz-de-Castro, V. Pereira, M. Hernandes, 2019, Front. Pharmacol..

Synthesis of aryl-hydrazones via ultrasound irradiation in aqueous medium

D. Moreira, A. Leite, F. D. Menezes, 2008 .

Schistosomicidal and prophylactic activities of phthalimido‐thiazoles derivatives on schistosomula and adult worms

F. Brayner, L. Alves, A. Leite, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vitro and in vivo activities of multi-target phtalimido-thiazoles on Schistosomiasis mansoni.

L. Alves, V. Pereira, A. Leite, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Phthalimido-thiazole as privileged scaffold: activity against immature and adult worms of Schistosoma mansoni

F. Brayner, L. Alves, A. Leite, 2018, Parasitology Research.

Evaluation of the Anti-Schistosoma mansoni Activity of Thiosemicarbazones and Thiazoles

A. C. da Silva, F. Brayner, L. Alves, 2013, Antimicrobial Agents and Chemotherapy.

Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues.

A. Leite, M. J. B. de Melo Rêgo, Paulo André Teixeira de Moraes Gomes, 2019, European journal of medicinal chemistry.

Privileged Structures in the design of Potential Drug Candidates for Neglected Diseases.

A. Leite, M. V. de Oliveira Cardoso, Gevânio Bezerra de Oliveira Filho, 2019, Current medicinal chemistry.

Synthesis of 4 0 -(2-ferrocenyl)-2,2 0 :6 0 2 00 -terpyridine: Characterization and antiprotozoal activity of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes European Journal of Medicinal Chemistry

M. Soares, D. Moreira, A. Leite, 2014 .

Isatin Derivatives and Their Antiviral Properties Against Arboviruses: A Review.

L. Pena, A. Leite, Paulo André Teixeira de Moraes Gomes, 2018, Mini reviews in medicinal chemistry.

Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes

D. Moreira, A. Leite, T. Silva, 2014, Medicinal Chemistry Research.

Novel phthalimide derivatives with TNF-α and IL-1β expression inhibitory and apoptotic inducing properties

L. Abraham, S. M. Cavalcanti, D. Moreira, 2014 .

Evaluating the Prophylaxis of the Risk of Deep Vein ThrombosisU sing Business Intelligence

J. Machado, A. Abelha, A. Leite, 2017 .

Structure-activity relationships of mononuclear metal-thiosemicarbazone complexes endowed with potent antiplasmodial and antiamoebic activities.

R. Srivastava, M. Soares, D. Moreira, 2010, Bioorganic & medicinal chemistry.

Synthesis, antitumour and antimicrobial activities of new peptidyl derivatives containing the 1,3-benzodioxole system.

J. M. de Araújo, A. Leite, D. Brondani,, 2004, European journal of medicinal chemistry.

SYNTHESIS OF PEPTIDYL BENZODIOXOLE DERIVATIVES FROM SAFROLE, A POTENTIAL CLASS OF ANTITUMOR DRUGS

A. Leite, A. de Faria, D. Brondani,, 2001 .

Anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazinecarbothioamide in mice

M. F. Fernandes-Pedrosa, M. Rêgo, M. Pitta, 2020, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.

R. S. Ferreira, R. Srivastava, C. Meira, 2012, Journal of medicinal chemistry.

A new and efficient N-alkylation procedure for semicarbazides/semicarbazones derivatives

D. Moreira, A. Leite, D. Brondani,, 2007 .

Aryl thiosemicarbazones: In vitro and immunomodulatory activities against L. amazonensis.

A. C. da Silva, V. Pereira, D. Moreira, 2017, Experimental parasitology.

Synthesis, Cruzain Docking, and in vitro Studies of Aryl‐4‐Oxothiazolylhydrazones Against Trypanosoma cruzi

M. Soares, M. Hernandes, A. Leite, 2007, ChemMedChem.

Anti‐liver cancer activity in vitro and in vivo induced by 2‐pyridyl 2,3‐thiazole derivatives

D. Bezerra, M. Soares, A. Leite, 2017, Toxicology and applied pharmacology.

Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents.

M. Soares, D. Moreira, A. Leite, 2009, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents.

M. Soares, D. Moreira, A. Leite, 2014, European journal of medicinal chemistry.

Synthesis of some 4-oxo-delta 2-thiazolin-2-ylhydrazones as potential antiprotozoal agents.

P. Gayral, A. Leite, A. Alves, 1993, Farmaco.

Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi.

M. Soares, M. Hernandes, D. Moreira, 2006, Bioorganic & medicinal chemistry.

Molecular drug design, synthesis and pharmacophore site identification of spiroheterocyclic compounds: Trypanosoma crusi inhibiting studies

T. Ben Hadda, A. Leite, V. Masand, 2012, Medicinal Chemistry Research.

Synthesis, anticancer activity and mechanism of action of new thiazole derivatives.

A. Leite, Miria de Oliveira Barbosa, P. A. T. Gomes, 2018, European journal of medicinal chemistry.

Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities.

E. T. Guimarães, M. Soares, M. Hernandes, 2015, European journal of medicinal chemistry.

Structural Insights Into Bioactive Thiazolidin-4-one: Experimental and Theoretical Data

C. A. Simone, M. Hernandes, D. Moreira, 2015 .

2-(phenylthio)ethylidene derivatives as anti-Trypanosoma cruzi compounds: Structural design, synthesis and antiparasitic activity.

R. S. Ferreira, C. Meira, M. Soares, 2019, European journal of medicinal chemistry.

Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi.

R. S. Ferreira, C. Meira, M. Soares, 2017, European journal of medicinal chemistry.

2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.

R. S. Ferreira, V. Pereira, M. Hernandes, 2014, European journal of medicinal chemistry.

Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death.

R. S. Ferreira, A. C. da Silva, V. Pereira, 2014, European journal of medicinal chemistry.

cruzi agents : Structural design , synthesis and Pharmacological evaluation

R. S. Ferreira, V. Pereira, M. Hernandes, 2014 .

Thiosemicarbazone and thiazole: in vitro evaluation of leishmanicidal and ultrastructural activity on Leishmania infantum

F. Brayner, A. S. Feitosa, L. Alves, 2020, Medicinal Chemistry Research.

Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics.

R. Srivastava, E. Antunes, A. Leite, 2000, Farmaco.

SYNTHESIS OF 1,3-BENZODIOXOLE DERIVATIVES CONTAINING A AMINO ACID MOIETY IN SIDE CHAIN

A. Leite, D. Brondani,, Kezia Peixoto da Silva,, 2001 .

Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure-activity relationships.

Henrique S. Oliveira, V. Pereira, D. Moreira, 2009, Bioorganic & medicinal chemistry.

Approaches for the development of new anti-Trypanosoma cruzi agents.

R. D. dos Santos, M. Soares, D. Moreira, 2009, Current drug targets.

Desing and synthesis of potent anti-Trypanosoma cruzi agents new thiazoles derivatives which induce apoptotic parasite death.

R. S. Ferreira, A. C. da Silva, V. Pereira, 2017, European journal of medicinal chemistry.

Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents.

Rafaela Salgado Ferreira, Marcelo Montenegro Rabello, Marcelo Zaldini Hernandes, 2010, Bioorganic & medicinal chemistry.

Recent insights on the medicinal chemistry of metal-based compounds: hints for the successful drug design.

M. Hernandes, D. Moreira, A. Leite, 2010, Current medicinal chemistry.

Phthalimido-thiazole as privileged scaffold: activity against immature and adult worms of Schistosoma mansoni

F. Brayner, L. Alves, A. Leite, 2018, Parasitology Research.

Cytotoxic and toxicological effects of phthalimide derivatives on tumor and normal murine cells.

D. Moreira, A. Leite, C. Pessoa, 2015, Anais da Academia Brasileira de Ciencias.

A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

A. Improta-Caria, C. Nonaka, B. Souza, 2021, Stem cells international.

Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells.

A. C. da Silva, D. Moreira, A. Leite, 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Study of in vitro biological activity of thiazoles on Leishmania (Leishmania) infantum.

R. Figueiredo, A. Leite, M. V. O. Cardoso, 2020 .

Phthalimido-thiazoles as building blocks and their effects on the growth and morphology of Trypanosoma cruzi.

F. Brayner, M. Soares, V. Pereira, 2016, European journal of medicinal chemistry.

Synthesis and structureeactivity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain

R. S. Ferreira, A. Romanha, M. Soares, 2015 .

SYNTHESIS OF NEW 1,2,4-OXADIAZOLES-DERIVED DIPEPTIDOMIMETICS, A POTENTIAL CLASS OF ANTIINFLAMMATORY DRUGS

R. Srivastava, A. Leite, D. Brondani,, 1999 .

Outstanding effect of the conformational restriction of isoquinolines: hints for the development of optimized antimicrobial agents

I. Orhan, T. Ben Hadda, A. Leite, 2013, Research on Chemical Intermediates.

Genotoxic activity of 3-[3-phenyl-1,2,4-oxadiazol-5-yl] propionic acid and its peptidyl derivatives determined by Ames and SOS response tests.

R. Srivastava, A. Leite, M. A. de Morais Junior, 2005, Mutation research.

Structural improvement of new thiazolidinones compounds with antinociceptive activity in experimental chemotherapy‐induced painful neuropathy

M. Soares, D. Moreira, A. Leite, 2017, Chemical biology & drug design.

Molecular drug design, synthesis and pharmacophore site identification of spiroheterocyclic compounds: Trypanosoma crusi inhibiting studies

T. Ben Hadda, A. Leite, V. Masand, 2012, Medicinal Chemistry Research.

Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes

D. Moreira, A. Leite, T. Silva, 2014, Medicinal Chemistry Research.

Structural design, synthesis, and anti-Trypanosomatidae profile of new Pyridyl-thiazolidinones.

F. Brayner, L. Alves, V. Pereira, 2023, European journal of medicinal chemistry.

Design, Synthesis and In Vitro Trypanocidal and Leishmanicidal Activities of 2‐(2‐Arylidene)hydrazono‐4‐oxothiazolidine‐5‐acetic Acid Derivatives

R. S. Ferreira, M. Tahir, S. Hameed, 2019 .