G. Sharman

发表

Burial of Hydrocarbon Causes Cooperative Enhancement of Electrostatic Binding

Bellinda Benhamú, Dudley H. Williams, M. Searle, 1995 .

Development of a selective TOCSY experiment and its use in analysis of a mixture of related compounds

G. Sharman, 1999 .

Standardization of Analytical Methodology and Procedures for Purity Assessment of Small Molecules in Drug Discovery

A. Espada, G. Sharman, A. Marín, 2014 .

Conformation and Stereochemical Analysis of Drug Molecules

G. Sharman, 2015 .

Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease: synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions

C. Garwood, Emma J. Mead, G. Sharman, 2019, Pure and Applied Chemistry.

Use of model cell membranes to demonstrate templated binding of vancomycin group antibiotics

Dudley H. Williams, B. Bardsley, G. Sharman, 1997 .

Binding of a vancomycin group antibiotic to a cell wall analogue from vancomycin-resistant bacteria

Dudley H. Williams, G. Sharman, R. Dancer, 1996 .

Common factors in the mode of action of vancomycin group antibiotics active against resistant bacteria

Dudley H. Williams, G. Sharman, 1997 .

Dissecting the effects of cooperativity on the stabilisation of a de novo designed three stranded anti-parallel β-sheet

G. Sharman, 1997 .

The roles of dimerization and membrane anchoring in activity of glycopeptide antibiotics against vancomycin-resistant bacteria

Younghoon R. Cho, Dudley H. Williams, M. Cooper, 1997 .

Structural elucidation of XR586, a peptaibol-like antibiotic from Acremonium persicinum.

D. Williams, S. Wrigley, T. Gibson, 1996, The Biochemical journal.

A quantitative application of the J‐based configuration analysis method to a flexible small molecule

G. Sharman, 2007, Magnetic resonance in chemistry : MRC.

Enhancement of Electrostatic Binding Through Cooperative Interactions: Enthalpy/Entropy Compensation and Peptide—Peptide Recognition

Dudley H. Williams, M. Searle, P. Groves, 1995 .

Critical investigation of coupled liquid chromatography–NMR spectroscopy in pharmaceutical impurity identification

I. C. Jones, G. Sharman, Ian Jones, 2003 .

Origin of β-Hairpin Stability in Solution: Structural and Thermodynamic Analysis of the Folding of a Model Peptide Supports Hydrophobic Stabilization in Water

M. Searle, G. Sharman, A. J. Maynard, 1998 .

The measurement of high enantiomeric excesses in chiral liquid crystals using 19F NMR and exchangeable protons in 2H NMR.

G. Sharman, A. Phillips, 2004, Chemical communications.

Janocchio—a Java applet for viewing 3D structures and calculating NMR couplings and NOEs

M. Bodkin, David A. Evans, G. Sharman, 2007, Magnetic resonance in chemistry : MRC.

Determination of the structure of exochelin MN, the extracellular siderophore from Mycobacterium neoaurum.

D. Williams, C. Ratledge, D. Ewing, 1995, Chemistry & biology.

Prion protein fragments spanning helix 1 and both strands of beta sheet (residues 125-170) show evidence for predominantly helical propensity by CD and NMR.

R. Mayer, M. Searle, G. Sharman, 1998, Folding & design.

Unlocking the potential of late-stage functionalisation: an accurate and fully automated method for the rapid characterisation of multiple regioisomeric products

Jeffery Richardson, Gary Sharman, Francisco Martínez-Olid, 2020 .

Isolation, purification and structure of exochelin MS, the extracellular siderophore from Mycobacterium smegmatis.

C Ratledge, D. Williams, C. Ratledge, 1995, The Biochemical journal.

Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures

Michele Zagnoni, Antigoni Katsikoudi, Gary Sharman, 2020, The Journal of Biological Chemistry.

1H and 13C NMR data to aid the identification and quantification of residual solvents by NMR spectroscopy

I. C. Jones, G. Sharman, J. Pidgeon, 2005, Magnetic resonance in chemistry : MRC.

Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)(2).

M. Searle, E. Gavathiotis, G. Sharman, 2000, Nucleic acids research.

Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrPC binding and downstream pathways

Matthew P. Baumgartner, V. Gillet, N. Colabufo, 2021, Chemical science.

Java applets for viewing one‐ and two‐dimensional NMR spectra

G. Sharman, 2006, Magnetic resonance in chemistry : MRC.

Evidence for β-sheet conformation in vesicle-bound peptides derived from the transmembrane bacterial flagellar motor protein MotB from Rhodobacter sphaeroides

R. Sockett, M. Searle, G. Sharman, 2000 .

Enthalpic (electrostatic) contribution to the chelate effect: a correlation between ligand binding constant and a specific hydrogen bond strength in complexes of glycopeptide antibiotics with cell wall analogues

Dudley H. Williams, M. Searle, D. Beauregard, 1996 .

A KNIME Workflow for Automated Structure Verification

Carlos Cobas, Gary Sharman, James A Lumley, 2020, SLAS discovery : advancing life sciences R & D.

Modulation of intrinsic phi,psi propensities of amino acids by neighbouring residues in the coil regions of protein structures: NMR analysis and dissection of a beta-hairpin peptide.

S. Griffiths-Jones, M. Searle, G. Sharman, 1998, Journal of molecular biology.

Demonstration of the difference in binding affinity between the two binding sites of the ristocetin A asymmetric dimer

Dudley H. Williams, G. Batta, G. Sharman, 1996 .