B. Benhamú

发表

Burial of Hydrocarbon Causes Cooperative Enhancement of Electrostatic Binding

Bellinda Benhamú, Dudley H. Williams, M. Searle, 1995 .

Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.

L. Pardo, J. Lavandera, J. Ramos, 2003, Journal of medicinal chemistry.

Study of the bioactive conformation of novel 5-HT4 receptor ligands: influence of an intramolecular hydrogen bond

L. Pardo, M. López-Rodríguez, A. Viso, 2001 .

Pd(0) Amination of Benzimidazoles as an Efficient Method towards New (Benzimidazolyl)piperazines with High Affinity for the 5-HT1A Receptor

J. Ramos, M. López-Rodríguez, A. Viso, 2000 .

New Trends in Aging Drug Discovery

M. López-Rodríguez, S. Ortega‐Gutiérrez, B. Benhamú, 2022, Biomedicines.

A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity.

J. Ballesteros, M. Loza, J. Brea, 2017, Journal of medicinal chemistry.

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

H. Aguilar, A. Urruticoechea, D. Haro, 2009, Clinical Cancer Research.

Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”

J. Ballesteros, M. Loza, J. Brea, 2022, Journal of medicinal chemistry.

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells

N. Auersperg, F. Hegardt, D. Serra, 2015, International journal of cancer.

2-(Fluoromethoxy)-4′-(S-methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson’s Disease

J. Ballesteros, M. Loza, J. Brea, 2022, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models.

M. López-Rodríguez, K. Schaper, B. Benhamú, 1997, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.

J. Manzanares, M. López-Rodríguez, A. Sanz, 1996, Journal of medicinal chemistry.

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

Leonardo Pardo, Bellinda Benhamú, L. Pardo, 2014, Journal of medicinal chemistry.

Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.

Jessica Sallander, Leonardo Pardo, Bellinda Benhamú, 2009, Journal of medicinal chemistry.

Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists.

L. Pardo, M. López-Rodríguez, A. Viso, 2002, Journal of medicinal chemistry.

Synthesis of Thiabicyclic Heterocycles Through Free Radical Cyclization of β-Thioacrylates

A. Melman, B. Benhamú, M. D. Bachi, 2000 .

Synthesis and structure-activity relationships of a new model of arylpiperazines. Part 7: Study of the influence of lipophilic factors at the terminal amide fragment on 5-HT1A affinity/selectivity

María L. López-Rodríguez, Bellinda Benhamú, J. Ramos, 2004 .

Stereospecificity in the Reaction of Tetrahydro-.beta.-carboline-3-carboxylic Acids with Isocyanates and Isothiocyanates. Kinetic vs Thermodynamic Control

J. D. L. Campa, M. López-Rodríguez, B. Benhamú, 1994 .

Reaction of 6-hydroxytetrahydro-beta-carboline-3-carboxylic acids with isocyanates and isothiocyanates.

B. Benhamú, L. Orensanz, E. Fernández, 1994, Chemical & pharmaceutical bulletin.

Stereospecificity in the Reaction of Tetrahydro‐β‐carboline‐3‐ carboxylic Acids with Isocyanates and Isothiocyanates. Kinetic vs Thermodynamic Control.

J. D. L. Campa, M. López-Rodríguez, B. Benhamú, 1994 .

New synthetic inhibitors of fatty acid synthase with anticancer activity.

M. Artola, D. Haro, M. López-Rodríguez, 2012, Journal of medicinal chemistry.

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines

H. Aguilar, A. Urruticoechea, M. López-Rodríguez, 2011, Breast Cancer Research.

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

C. Singer, E. Karteris, P. Valent, 2017, Oncotarget.

Arylpiperazine derivatives acting at 5-HT(1A) receptors.

M. López-Rodríguez, A. Viso, B. Benhamú, 2002, Current medicinal chemistry.

First pharmacophoric hypothesis for 5-HT7 antagonism.

J. Lavandera, J. Ramos, M. López-Rodríguez, 2000, Bioorganic & medicinal chemistry letters.

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

Jessica Sallander, Leonardo Pardo, Bellinda Benhamú, 2010, Journal of medicinal chemistry.

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

Leonardo Pardo, Bellinda Benhamú, Mercedes Campillo, 2005, Journal of medicinal chemistry.

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

L. Pardo, A. Planas, J. Ramos, 2011, Journal of medicinal chemistry.

Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.

M. Delgado, M. A. Pozo, J. Manzanares, 2005, European journal of pharmacology.

Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy.

L. Pardo, K. Wüthrich, P. Serrano, 2011, Journal of medicinal chemistry.

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

Gianluigi Caltabiano, Leonardo Pardo, Bellinda Benhamú, 2014, Journal of medicinal chemistry.

Allosteric modulators targeting GPCRs

M. López-Rodríguez, B. Benhamú, Henar Vázquez-Villa, 2020 .

Computational Model of the Complex between GR113808 and the 5-HT4 Receptor Guided by Site-Directed Mutagenesis and the Crystal Structure of Rhodopsin

Leonardo Pardo, Marta Murcia, Mireia Olivella, 2001, J. Comput. Aided Mol. Des..

Development of molecular probes for the human 5-HT(6) receptor.

J. A. González-Vera, E. Junquera, E. Aicart, 2010, Journal of medicinal chemistry.

Development of Fluorescent Ligands for the Human 5-HT1A Receptor.

E. Junquera, E. Aicart, M. López-Rodríguez, 2010, ACS medicinal chemistry letters.

Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.

M. Delgado, L. Pardo, J. Manzanares, 2003, Bioorganic & medicinal chemistry letters.

Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites*

María L. López-Rodríguez, Bellinda Benhamú, María José Morcillo, 1997, J. Comput. Aided Mol. Des..

Computational Simulation of Ligand-Receptor Interaction of 5-HT 1 AR Agonists with Selectivity over r 1-Adrenoceptors

M. Delgado, L. Pardo, J. Manzanares, 2022 .

Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors.

J. A. González-Vera, J. López, Ainoa Rueda-Zubiaurre, 2016, Chemistry.

Enthalpic (electrostatic) contribution to the chelate effect: a correlation between ligand binding constant and a specific hydrogen bond strength in complexes of glycopeptide antibiotics with cell wall analogues

Dudley H. Williams, M. Searle, D. Beauregard, 1996 .

5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions.

L. Pardo, M. López-Rodríguez, A. Viso, 2002, Current topics in medicinal chemistry.

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

L. Pardo, M. López-Rodríguez, B. Benhamú, 2014, Journal of medicinal chemistry.

A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding

L. Pardo, J. A. González-Vera, M. López-Rodríguez, 2017, Scientific Reports.

Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors.

J. A. González-Vera, J. López, Ainoa Rueda-Zubiaurre, 2016, Chemistry.

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells

N. Auersperg, F. Hegardt, D. Serra, 2015, International journal of cancer.

Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors.

M. López-Rodríguez, B. Benhamú, M. Martín, 1999, Journal of medicinal chemistry.

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

J. C. Gómez-Tamayo, L. Pardo, M. López-Rodríguez, 2014, Journal of medicinal chemistry.

New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.

J. Ramos, M. López-Rodríguez, B. Benhamú, 2013, Journal of medicinal chemistry.

Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists

Marta Murcia, Leonardo Pardo, María L. López-Rodríguez, 2003, J. Comput. Aided Mol. Des..

The importance of solvation in the design of ligands targeting membrane proteins

L. Pardo, M. López-Rodríguez, M. Murcia, 2011 .

Cancer-Stem-Cell Phenotype-Guided Discovery of a Microbiota-Inspired Synthetic Compound Targeting NPM1 for Leukemia

M. López-Rodríguez, B. Benhamú, Henar Vázquez-Villa, 2024, JACS Au.

Serotonin 5-HT7 Receptor Antagonists

L. Pardo, J. Lavandera, M. López-Rodríguez, 2004 .

Benzimidazole derivatives. Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

M. López-Rodríguez, B. Benhamú, L. Schiapparelli, 2004, Bioorganic & medicinal chemistry.

Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

M. López-Rodríguez, B. Benhamú, L. Schiapparelli, 2003, Bioorganic & medicinal chemistry letters.