I. Chen

发表

Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position.

J. Vacca, S. Gardell, T. Tucker, 1997, Journal of medicinal chemistry.

Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction .

J. Lin, M. Yamazaki, M. Chiba, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Differential renal handling of angiotensin-converting enzyme inhibitors enalaprilat and lisinopril in rats.

J. Lin, E. Ulm, I. Chen, 1988, Drug metabolism and disposition: the biological fate of chemicals.

pH-dependent oral absorption of L-735,524, a potent HIV protease inhibitor, in rats and dogs.

J. Lin, I. Chen, D. Ostovic, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine.

R. Miller, J. Lin, B. Arison, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.

J. Vacca, J. Shafer, Z. Chen, 1998, Journal of medicinal chemistry.

Quantitation of a new cholecystokinin and gastrin receptor antagonist (L-365,260) in dog and rat plasma by high-performance liquid chromatography.

J. Lin, I. Chen, J. Dorley, 1992, Journal of chromatography.

Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals.

J. Lin, I. Chen, D. E. Duggan, 1991, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacokinetics and metabolism of a RAS farnesyl transferase inhibitor in rats and dogs: in vitro-in vivo correlation.

J. Lin, B. Wong, B. Arison, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug.

I. Chen, D. E. Duggan, A. Rosegay, 1990, Drug metabolism and disposition: the biological fate of chemicals.

The physiological disposition of lovastatin.

I. Chen, R. Stubbs, D. E. Duggan, 1989, Drug Metabolism And Disposition.

Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in rats.

J. Lin, I. Chen, D. E. Duggan, 1992, Drug metabolism and disposition: the biological fate of chemicals.

Renal handling of alendronate in rats. An uncharacterized renal transport system.

J. Lin, I. Chen, F. Deluna, 1992, Drug metabolism and disposition: the biological fate of chemicals.

Interaction with indinavir to enhance systemic exposure of an investigational HIV protease inhibitor in rats, dogs and monkeys

J. Lin, M. Chiba, I. Chen, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy.

J. Vacca, S. Gardell, T. Tucker, 1997, Journal of medicinal chemistry.

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor.

J. Vacca, J. Shafer, Z. Chen, 1998, Bioorganic & medicinal chemistry letters.

C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption.

J. Vacca, S. Gardell, S. D. Lewis, 1998, Bioorganic & medicinal chemistry letters.

Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.

C. Coburn, J. Vacca, S. D. Lewis, 2000, Bioorganic & medicinal chemistry letters.

Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.

S. Brady, J. Vacca, S. Gardell, 1998, Journal of medicinal chemistry.

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position.

M. Bock, R. Freidinger, J. Vacca, 1997, Journal of medicinal chemistry.

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.

Mark Embrey, Samson M Jolly, Wei Xu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.

D. Hazuda, Jiunn H. Lin, W. Schleif, 2005, Bioorganic & medicinal chemistry letters.

Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.

C. Coburn, J. Vacca, S. D. Lewis, 2000, Bioorganic & medicinal chemistry letters.

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency.

A. Simon, G. McGaughey, J. Barrow, 2015, Bioorganic & medicinal chemistry letters.

High-performance liquid chromatographic determination of cilastatin and its major metabolite N-acetylcilastatin in rat plasma, urine and bile.

J. Lin, I. Chen, D. E. Duggan, 1990, Journal of chromatography.

Synthesis and evaluation of pyridyl analogs of L-735,524: Potent HIV-1 protease inhibitors

P. Anderson, Jiunn H. Lin, P. Darke, 1994 .

Cycloalkylpiperazines as HIV-1 protease inhibitors: enhanced oral absorption

B. E. Evans, P. Anderson, Jiunn H. Lin, 1995 .

Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

High-performance liquid chromatographic determination of a potent and selective HIV protease inhibitor (L-735,524) in rat, dog and monkey plasma.

J. Lin, I. Chen, K. Vastag, 1995, Journal of chromatography. B, Biomedical applications.

In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results.

J. Hochman, J. Lin, T. Ohe, 2001, The Journal of pharmacology and experimental therapeutics.

On the absorption of alendronate in rats.

J. Lin, I. Chen, F. Deluna, 1994, Journal of pharmaceutical sciences.

Regiospecific Intestinal Absorption of the HIV Protease Inhibitor L-735,524 in Beagle Dogs

Gloria Kwei, I. Chen, G. Kwei, 1995, Pharmaceutical Research.

Effect of Dexamethasone on the Intestinal First-Pass Metabolism of Indinavir in Rats: Evidence of Cytochrome P-450 A and p-Glycoprotein Induction

M. Yamazaki, M. Chiba, I. Chen, 1999 .

Dose-Dependent Pharmacokinetics of MK-417, a Potent Carbonic Anhydrase Inhibitor, in Experimental Polycythemic and Anemic Rats

I. Chen, F. Deluna, J. Lin, 1991, Pharmaceutical Research.

Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.

E A Emini, L. Kuo, P. Darke, 2000, Journal of medicinal chemistry.

Metabolite identification of small interfering RNA duplex by high-resolution accurate mass spectrometry.

J. Hochman, I. Chen, M. Beverly, 2008, Rapid communications in mass spectrometry : RCM.

Nonlinear kinetics of alendronate. Plasma protein binding and bone uptake.

J. Lin, I. Chen, F. Deluna, 1994, Drug metabolism and disposition: the biological fate of chemicals.

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

S K Balani, J. Lin, M. Chiba, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Physiological disposition of L-663,581, a partial agonist of the benzodiazepine receptor, in laboratory animals.

J. Lin, I. Chen, 1994, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis of conformationally constrained 5,6,7, 8-Tetrahydroimidazo[1,5-a]pyridine inhibitors of farnesyltransferase.

J. Huff, T. Olah, I. Chen, 2000, Organic letters.

Physiological disposition and metabolism of L-365,260, a potent antagonist of brain cholecystokinin receptor, in laboratory animals.

J. Lin, S. Pitzenberger, I. Chen, 1992, Drug metabolism and disposition: the biological fate of chemicals.

Sex-dependent pharmacokinetics of indinavir: in vivo and in vitro evidence.

J. Lin, M. Chiba, I. Chen, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s.

J. Hochman, C. Tang, J. Lin, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Route-dependent nonlinear pharmacokinetics of a novel HIV protease inhibitor: involvement of enzyme inactivation.

J. Lin, M. Chiba, I. Chen, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Role of calcium in plasma protein binding and renal handling of alendronate in hypo- and hypercalcemic rats.

J. Lin, I. Chen, F. Deluna, 1993, The Journal of pharmacology and experimental therapeutics.

Substituted alkylpyridines as P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors: Improved pharmacokinetic profiles

P. Anderson, P. Darke, W. Schleif, 1995 .

Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors

P. Anderson, P. Darke, W. Schleif, 1995 .

A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability

P. Anderson, P. Darke, W. Schleif, 1994 .

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2006, Bioorganic & medicinal chemistry letters.

Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.

S. Brady, J. Vacca, S. Gardell, 1998, Journal of medicinal chemistry.

Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2007, Bioorganic & medicinal chemistry letters.

L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

P. Anderson, W. Schleif, E. Emini, 1995, Antimicrobial agents and chemotherapy.

Metabolite-P450 complex formation by methylenedioxyphenyl HIV protease inhibitors in rat and human liver microsomes.

J. Vacca, J. Lin, M. Chiba, 1998, Biochemical pharmacology.

Metabolite identification of small interfering RNA duplex by high-resolution accurate mass spectrometry.

J. Hochman, I. Chen, M. Beverly, 2008, Rapid communications in mass spectrometry : RCM.