Hongjiang Zhang

发表

5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase.

Gulzar Ahmed, Arthur M Doweyko, Axel Metzger, 2005, Journal of medicinal chemistry.

Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor.

James Lin, K. McIntyre, D. Shuster, 2015, Journal of medicinal chemistry.

Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.

A. Doweyko, K. McIntyre, D. Shuster, 2011, Bioorganic & medicinal chemistry letters.

5-amino-pyrazoles as potent and selective p38α inhibitors.

A. Doweyko, R. Moquin, K. McIntyre, 2010, Bioorganic & medicinal chemistry letters.

Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.

A. Doweyko, R. Moquin, K. McIntyre, 2008, Bioorganic & medicinal chemistry letters.

Characterization of the UDP Glucuronosyltransferase Activity of Human Liver Microsomes Genotyped for the UGT1A1*28 Polymorphism

W. Humphreys, J. Gambardella, Hongjiang Zhang, 2007, Drug Metabolism and Disposition.

UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3.

Jianqing Ruan, Hongjiang Zhang, Linghua Kong, 2019, Chemico-biological interactions.

Gastrointestinal stability, physicochemical characterization and oral bioavailability of chitosan or its derivative-modified solid lipid nanoparticles loading docetaxel

Hongjiang Zhang, Yue Cao, J. Cui, 2017, Drug development and industrial pharmacy.

LC-MS/MS method for the simultaneous quantitation of three active components derived from a novel prodrug against schistosome infection.

Chunhua Qiao, Hongjiang Zhang, Fengjiao Wen, 2013, Journal of pharmaceutical and biomedical analysis.

TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis

Yuanjia Hu, Cuiping Liu, Xue-guang Zhang, 2016, Oncotarget.

Pharmacokinetic Drug Interactions Involving 17α-Ethinylestradiol

A. D. Rodrigues, P. Balimane, Hongjiang Zhang, 2007 .

Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds.

Hongjiang Zhang, Huixin Qi, Meiyu Wang, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

AM22, a novel synthetic microRNA, inhibits the proliferation of colorectal cancer cells by targeting core binding factor subunit β (CBFB)

Hongjiang Zhang, F. Meng, Weipeng Wang, 2022, Investigational New Drugs.

Rs7911488 modified the efficacy of capecitabine-based therapy in colon cancer through altering miR-1307-3p and TYMS expression

D. Hua, Y. Mao, Hongjiang Zhang, 2017, Oncotarget.

Design, Synthesis, and Structure-Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity.

Zhijian Sun, Sheng Tian, L. Luo, 2017, ACS chemical neuroscience.

A novel hedgehog inhibitor for the treatment of hematological malignancies

X. Mao, B. Cao, Xiaohu Zhang, 2018, Anti-cancer drugs.

Confirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in Vitro

A. D. Rodrigues, Hongjiang Zhang, B. Wen, 2008, Drug Metabolism and Disposition.

Metabolic Activation of Rhein: Insights into the Potential Toxicity Induced by Rhein-Containing Herbs.

Jianqing Ruan, Hongjiang Zhang, Jiyue Zheng, 2016, Journal of agricultural and food chemistry.

Positively Charged Surface-Modified Solid Lipid Nanoparticles Promote the Intestinal Transport of Docetaxel through Multifunctional Mechanisms in Rats.

Hongjiang Zhang, Yue Cao, J. Cui, 2016, Molecular pharmaceutics.

Selective Itk inhibitors block T-cell activation and murine lung inflammation.

A. Doweyko, S. Spergel, R. Moquin, 2004, Biochemistry.

Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro

Hongjiang Zhang, Yedong Wang, Jia Lu, 2018, Molecules.

Reduction of Site-Specific CYP3A-Mediated Metabolism for Dual Angiotensin and Endothelin Receptor Antagonists in Various in Vitro Systems and in Cynomolgus Monkeys

W. Humphreys, N. Murugesan, Z. Gu, 2007, Drug Metabolism and Disposition.

The Thyroid Hormone Receptor-β-Selective Agonist GC-1 Differentially Affects Plasma Lipids and Cardiac Activity.

B. Gloss, J. Baxter, G. Grover, 2000, Endocrinology.

Pharmacokinetic drug interactions involving 17alpha-ethinylestradiol: a new look at an old drug.

A. D. Rodrigues, P. Balimane, Hongjiang Zhang, 2007, Clinical pharmacokinetics.

Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.

A. Doweyko, James Lin, J. Wityak, 2010, Journal of medicinal chemistry.

Antitumor activity of mianserin (a tetracyclic antidepressant) primarily driven by the inhibition of SLC1A5-mediated glutamine transport

C. Gui, Zhiyun Zhou, Hongjiang Zhang, 2022, Investigational New Drugs.

(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.

W. Humphreys, R. Seethala, P. Sleph, 2008, Bioorganic & medicinal chemistry letters.

Interaction between rhein acyl glucuronide and methotrexate based on human organic anion transporters.

Ping Li, Hua Yang, Jianqing Ruan, 2017, Chemico-biological interactions.

Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Ping Chen, Derek J. Norris, J. Tokarski, 2011, Bioorganic & medicinal chemistry letters.

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates.

Hongjiang Zhang, Yedong Wang, Jia Lu, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.

W. Humphreys, K. Dickinson, R. Seethala, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).

W. Humphreys, K. Dickinson, R. Seethala, 2007, Journal of medicinal chemistry.

Benzothiazole based inhibitors of p38alpha MAP kinase.

A. Doweyko, James Lin, Sidney Pitt, 2008, Bioorganic & medicinal chemistry letters.

Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.

John Dodd, John S Tokarski, Arthur M Doweyko, 2008, Journal of medicinal chemistry.

Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

J. Fargnoli, Derek J. Norris, J. Tokarski, 2009, Journal of medicinal chemistry.

CYP2C8-mediated interaction between repaglinide and steviol acyl glucuronide: In vitro investigations using rat and human matrices and in vivo pharmacokinetic evaluation in rats.

Hongjiang Zhang, Dandan Zhou, Yedong Wang, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of Huperzine A in mice.

Hongjiang Zhang, Dandan Zhou, Meiyu Wang, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis

Yun-di Guo, Jing Sun, Hongjiang Zhang, 2022, Cell death discovery.

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and their Utility for Predicting Drug–Drug Interactions

Stephen Fowler, Hongjiang Zhang, S. Fowler, 2008, The AAPS Journal.

Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds.

G. Derbin, P. Marathe, Hongjiang Zhang, 2011, Journal of pharmaceutical sciences.

Investigation of the interactions between flavonoids and human organic anion transporting polypeptide 1B1 using fluorescent substrate and 3D-QSAR analysis.

C. Gui, Zhongmin Wang, Hongjiang Zhang, 2020, Biochimica et biophysica acta. Biomembranes.

Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism.

A. D. Rodrigues, Jinping Gan, Yuan Tian, 2010, British journal of clinical pharmacology.

Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats

Ming Yao, Richard A. Morrison, S. Chong, 2003, Archives of pharmacal research.

Shift in pH of biological fluids during storage and processing: effect on bioanalysis.

A. Fura, Hongjiang Zhang, W. Shyu, 2003, Journal of pharmaceutical and biomedical analysis.

Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake

C. Gui, Hongjiang Zhang, Mei-zhi Shi, 2016, Pharmaceutical biology.

Design, synthesis and evaluation of a series of non-steroidal anti-inflammatory drug conjugates as novel neuroinflammatory inhibitors.

Xuechu Zhen, Xuechu Zhen, L. Zheng, 2015, International immunopharmacology.

Concomitant inhibition of B7-H3 and PD-L1 expression by a novel and synthetic microRNA delivers potent antitumor activities in colorectal tumor models

Hongjiang Zhang, F. Meng, Weipeng Wang, 2021, Investigational New Drugs.

Design, synthesis, and structure--activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists.

Zhijian Sun, L. Luo, Xiaohu Zhang, 2015, European journal of medicinal chemistry.

A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma

X. Mao, B. Cao, Jingyu Zhu, 2014, Oncotarget.

Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold.

Shuaishuai Chen, L. Luo, Xiaohu Zhang, 2016, Bioorganic & medicinal chemistry.

Mechanistic Studies on the Absorption and Disposition of Scutellarin in Humans: Selective OATP2B1-Mediated Hepatic Uptake Is a Likely Key Determinant for Its Unique Pharmacokinetic Characteristics

Xiaoyan Chen, D. Zhong, Chunying Gao, 2012, Drug Metabolism and Disposition.

Preclinical Antitumor Activity of BMS-599626, a pan-HER Kinase Inhibitor That Inhibits HER1/HER2 Homodimer and Heterodimer Signaling

J. Hunt, F. Lee, B. Fink, 2006, Clinical Cancer Research.

Human Organic Anion Transporting Polypeptides 1B1, 1B3, and 2B1 Are Involved in the Hepatic Uptake of Phenolsulfonphthalein

C. Gui, Zhongmin Wang, Hongjiang Zhang, 2021, ACS omega.

TGF‐β1 elevates P‐gp and BCRP in hepatocellular carcinoma through HOTAIR/miR‐145 axis

Hongjiang Zhang, Weipeng Wang, Yajing Qiu, 2019, Biopharmaceutics & drug disposition.

Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis

Xiaohu Zhang, Hongjiang Zhang, Yangxin Li, 2019, Cell Death & Disease.

Pathway-Dependent Inhibition of Paclitaxel Hydroxylation by Kinase Inhibitors and Assessment of Drug–Drug Interaction Potentials

P. Pan, Hongjiang Zhang, Yedong Wang, 2014, Drug Metabolism and Disposition.

Pathway-Dependent Inhibition of Paclitaxel Hydroxylation by Kinase Inhibitors and Assessment of Drug – Drug Interaction Potentials s

P. Pan, Hongjiang Zhang, Yedong Wang, 2014 .

Microsoft Word-19339517-file00

P. Pan, Hongjiang Zhang, Yedong Wang, 2014 .

A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma.

S. Chong, R. Morrison, Hongjiang Zhang, 2003, Journal of pharmaceutical and biomedical analysis.

The polymorphic terminal-loop of pre-miR-1307 binding with MBNL1 contributes to colorectal carcinogenesis via interference with Dicer1 recruitment.

Cuiping Liu, D. Hua, Y. Mao, 2015, Carcinogenesis.

Cytochrome P450 reaction-phenotyping: an industrial perspective

A. D. Rodrigues, Hongjiang Zhang, Michael W Sinz, 2007, Expert opinion on drug metabolism & toxicology.

Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids

C. Gui, Hongjiang Zhang, Shuai Liu, 2020, Frontiers in Pharmacology.

Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.

A. Doweyko, S. Spergel, R. Moquin, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor.

Michael A. Galella, James Lin, G. Schieven, 2013, Bioorganic & Medicinal Chemistry Letters.

Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis.

A. D. Rodrigues, W. Humphreys, R. Dai, 2007, Journal of pharmaceutical and biomedical analysis.

The importance of OATP1B1 and 1B3 in the liver uptake of luteolin and its consequent glucuronidation metabolites.

Jianqing Ruan, Hongjiang Zhang, Yuan Yuan, 2020, Journal of agricultural and food chemistry.

Effect of Commonly Used Organic Solvents on the Kinetics of Cytochrome P450 2B6- and 2C8-Dependent Activity in Human Liver Microsomes

P. Marathe, Hongjiang Zhang, Shu-Ying Chang, 2007, Drug Metabolism and Disposition.

Metabolism‐Mediated Drug–Drug Interactions

A. D. Rodrigues, Hongjiang Zhang, M. Sinz, 2007 .

Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis

Xiaohu Zhang, Hongjiang Zhang, Yangxin Li, 2019, Cell Death & Disease.

Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system.

Zhijian Sun, L. Luo, Xiaohu Zhang, 2016, European journal of medicinal chemistry.

Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1).

C. Gui, Zhongmin Wang, Hongjiang Zhang, 2020, Molecular pharmaceutics.

Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2.

P. Marathe, T. Wong, Hongjiang Zhang, 2010, Journal of pharmaceutical sciences.

Interaction of OAT3-Mediated Uptake of Steviol Acyl Glucuronide, a Major Metabolite of Rebaudioside A, with Selected Drugs.

C. Gui, Hongjiang Zhang, Dandan Zhou, 2019, Journal of agricultural and food chemistry.

A functional variant at miR-24 binding site in B7-H2 alters susceptibility to gastric cancer in a Chinese Han population.

Wei-peng Wang, D. Hua, Y. Mao, 2013, Molecular immunology.

Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.

A. Doweyko, K. McIntyre, D. Shuster, 2008, Bioorganic & medicinal chemistry letters.

Enhanced Antitumor Activity of Monophosphate Ester Prodrugs of Gemcitabine: In Vitro and In Vivo Evaluation.

Hongjiang Zhang, Yedong Wang, Jia Lu, 2016, Journal of pharmaceutical sciences.

Involvement of Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes in the in Vitro Metabolism of Muraglitazar

W. Humphreys, Hongjiang Zhang, Donglu Zhang, 2007, Drug Metabolism and Disposition.

Tryptophan Residue Located at the Middle of Putative Transmembrane Domain 11 Is Critical for the Function of Organic Anion Transporting Polypeptide 2B1.

C. Gui, Hongjiang Zhang, Meiyu Wang, 2016, Molecular pharmaceutics.

Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor.

L. Zheng, Shuaishuai Chen, L. Luo, 2018, European journal of medicinal chemistry.

Optimization of 6-heterocyclic-2-(1H-pyrazol-1-yl)-N-(pyridin-2-yl)pyrimidin-4-amine as potent adenosine A2A receptor antagonists for the treatment of Parkinson's disease.

Xuechu Zhen, LinLang Li, Xiaohu Zhang, 2014, ACS chemical neuroscience.

Effect of rare coding variants of charged amino acid residues on the function of human organic anion transporting polypeptide 1B3 (SLCO1B3).

C. Gui, Zhongmin Wang, Hongjiang Zhang, 2021, Biochemical and biophysical research communications.

Gly45 and Phe555 in Transmembrane Domains 1 and 10 are Critical for the Activation of OATP1B3 by Epigallocatechin Gallate.

C. Gui, Hongjiang Zhang, B. Hagenbuch, 2019, Journal of agricultural and food chemistry.

Hormetic effects of EGC and EGCG on CES1 activity and its rescue from oxidative stress in rat liver S9.

Zhiyun Zhou, Hongjiang Zhang, Xiaoting Luo, 2023, Chemico-biological interactions.

A polymorphism in ABCC4 is related to efficacy of 5-FU/capecitabine-based chemotherapy in colorectal cancer patients

D. Hua, Y. Mao, Hongjiang Zhang, 2017, Scientific Reports.

Confirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in Vitro

Hongjiang Zhang, B. Wen, Shu-Ying Chang, 2008, Drug Metabolism and Disposition.

CYP2C8-mediated interaction between repaglinide and steviol acyl glucuronide: In vitro investigations using rat and human matrices and in vivo pharmacokinetic evaluation in rats.

Hongjiang Zhang, Dandan Zhou, Yedong Wang, 2016, Food and Chemical Toxicology.