Jean Quancard

发表

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space

Rajiv Chopra, Meir Glick, Florian Nigsch, 2010, Protein science : a publication of the Protein Society.

Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.

A. Schuffenhauer, E. Altmann, G. Bold, 2020, Journal of medicinal chemistry.

Requirement of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor–Induced Arthritis, but Not Fcγ Receptor–Mediated Platelet Elimination, in Mice

T. Junt, E. Degl'innocenti, G. Wieczorek, 2020 .

Prolinoamino acids as a tool to stabilize β-turns with the side chain of natural amino acids

A. Aubry, O. Lequin, P. Karoyan, 2004 .

The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition

G. Bold, M. Renatus, J. Kovarik, 2018, Immunology and cell biology.

Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.

E. Altmann, U. Hassiepen, M. Renatus, 2017, Angewandte Chemie.

The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes

Stéphanie M. Guéret, G. Sbardella, D. Finsinger, 2020, ChemMedChem.

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

R. Hersperger, C. Overall, M. Renatus, 2019, Nature Chemical Biology.

Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

R. Hersperger, N. Beckmann, H. Otto, 2016, PloS one.

Development of potent inhibitors of botulinum neurotoxin type B.

S. Turcaud, B. Roques, H. Meudal, 2003, Journal of medicinal chemistry.

Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.

M. Renatus, M. Wartmann, S. Melkko, 2020, Journal of medicinal chemistry.

A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.

R. Hersperger, K. Seuwen, V. Brinkmann, 2012, Chemistry & biology.

Targeted inhibition of the COP9 signalosome for treatment of cancer

E. Altmann, U. Hassiepen, M. Renatus, 2016, Nature Communications.

Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology

C. Beerli, Jean Quancard, A. Schlapbach, 2020, Frontiers in Immunology.

Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver.

E. Lightcap, R. Silverman, Jean Quancard, 2003, The international journal of biochemistry & cell biology.

Palladium-catalyzed enantioselective C-3 allylation of 3-substituted-1H-indoles using trialkylboranes.

B. Trost, Jean Quancard, 2006, Journal of the American Chemical Society.

Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity

M. Renatus, C. Wiesmann, F. Villard, 2020 .

Amino-zinc-ene-enolate cyclisation: a short access to (2S,3R)- and (2S,3S)-3-benzylprolines (3-benzylpyrrolidine-2-carboxylic acids)

P. Karoyan, S. Lavielle, G. Chassaing, 2004 .

Amino-zinc-enolate carbometalation reactions: application to ring closure of terminally substituted olefin for the asymmetric synthesis of cis- and trans-3-prolinoleucine.

P. Karoyan, G. Chassaing, Jean Quancard, 2003, The Journal of organic chemistry.

Asymmetric synthesis of 3-substituted proline chimeras bearing polar side chains of proteinogenic amino acids.

Y. Jacquot, P. Karoyan, S. Lavielle, 2004, The Journal of organic chemistry.

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.

A. Schuffenhauer, M. Renatus, M. Wartmann, 2018, Bioorganic & medicinal chemistry letters.

An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.

R. Hersperger, M. Streiff, C. Pally, 2012, Journal of medicinal chemistry.

Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance P bound to the NK-1 receptor.

S. Sagan, O. Lequin, P. Karoyan, 2005, Chemistry & biology.

Prolinoamino Acids as Tools to Build Bifunctionalized, Stable β‐Turns in Water

O. Lequin, N. Goasdoué, P. Karoyan, 2009, Chembiochem : a European journal of chemical biology.

Characterization of the bioactive conformation of the C-terminal tripeptide Gly-Leu-Met-NH2 of substance P using [3-prolinoleucine10]SP analogues.

S. Sagan, O. Lequin, P. Karoyan, 2003, European journal of biochemistry.

The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery

Stéphanie M. Guéret, G. Sbardella, D. Finsinger, 2021, ChemMedChem.

T. Junt, E. Degl'innocenti, G. Wieczorek, 2020, Arthritis & rheumatology.

Substituted Prolines: Syntheses and Applications in Structure—Activity Relationship Studies of Biologically Active Peptides

S. Sagan, O. Lequin, P. Karoyan, 2006 .

The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit Generation

Stéphanie M. Guéret, A. Vulpetti, G. Sbardella, 2023, ChemMedChem.

An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.

R. Hersperger, M. Streiff, C. Pally, 2012, Journal of medicinal chemistry.