C. Holzapfel

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STILLE AND SUZUKI CROSS COUPLING REACTIONS OF O-NITROPHENYL TRIFLATES : A VERSATILE ROUTE TO A VARIETY OF HETEROCYCLES

C. Holzapfel, C. Dwyer, 1998 .

Hydroformylation of 2‐Alkynylanilines: Toward an Alternative Methodology for the Synthesis of 3‐Substituted Indoles

C. Holzapfel, E. Dasilva, Laetitia Den Drijver, 2016 .

The structure and some aspects of the biosynthesis of pleuromutilin

C. Holzapfel, A. Birch, R. Rickards, 1966 .

The selective continuous flow synthesis of lower alcohols from polyols – a mechanistic interpretation of the results

H. Friedrich, C. Holzapfel, A. Mahomed, 2014 .

Stereocontrolled palladium(0) catalysed cyclisation and cyclisation/carbonylation of pseudoglycal derivatives

C. Holzapfel, F. Toerien, G. J. Engelbrecht, 1997 .

Polymerization Assisted Reduction Reaction: A Sequential Electron–Proton Transfer Reaction Catalyzed by Gold Nanoparticle

M. Witcomb, R. Islam, M. Choudhary, 2013 .

The role of essential histidines in the mechanism of catalysis of the flavoenzyme, beta-cyclopiazonate oxidocyclase.

D. J. Steenkamp, J. C. Schabort, C. Holzapfel, 1974, Biochimica et biophysica acta.

Chiral Cyclobutanols and CyclopentaneDimers via Samarium(II) Iodide Induced Keto-Olefin Cyclisationsof Carbohydrate-Derived Unsaturated Ketones

D. Williams, C. Holzapfel, Kevin Blann, 2009 .

Characterization of a γ-radiation-induced antifungal stress metabolite in citrus peel

J. C. Schabort, I. Dubery, C. Holzapfel, 1988 .

The isolation and structure of a toxic metabolite from Diplodia maydis (Berk.) Sacc.

P. Wessels, P. Steyn, C. Holzapfel, 1972 .

The biosynthesis of the ochratoxins, metabolites of aspergillus ochraceus

P. Steyn, C. Holzapfel, N. P. Ferreira, 1970 .

Designing biaryl phosphacyclic ligands: their characterization and evaluation in palladium-catalyzed Suzuki-Miyaura reactions of aryl bromides and chlorides

C. Holzapfel, Jairus L. Lamola, Paseka T. Moshapo, 2021, Phosphorus, Sulfur, and Silicon and the Related Elements.

Toward the development of efficient and stable Pd-catalysts for the methoxycarbonylation of medium chain alkenes

C. Holzapfel, T. Bredenkamp, 2016, Journal of the Iranian Chemical Society.

An Empirical Study of Phosphine Ligands for the Methoxycarbonylation of Medium‐Chain Alkenes

C. Holzapfel, T. Bredenkamp, 2015 .

The synthesis and analysis of the conformation in solution of the dolastatin 3 diastereomer cyclo[-L-Pro-L-Leu-D-(Gln)Thz-(Gly)Thz-L-Val-]

C. Holzapfel, M. Bredenkamp, W. V. Zyl, 1990 .

Observations on the samarium diiodide-promoted C–C fragmentation/ring expansion chemistry of some aliphatic 1,4-diketones

D. Williams, C. Holzapfel, Kevin Blann, 2001 .

Reactions of Dicarbonyl(η5-Cyclopentadienyl)Iron(II)-Complexes of Two Cyclic Enol Ethers with Selected Nucleophiles

C. Holzapfel, M. Bredenkamp, J. F. Booysen, 1989 .

Synthesis of a Functionalised 4-Prenylated Indole Using a Carboxolytic Cleavage Reaction

C. Holzapfel, W. Hattingh, M. S. V. Dyk, 1987 .

-cyclopiazonate oxidocyclase from Penicillium cyclopium. I. Assay methods, isolation and purification.

J. C. Schabort, A. Neitz, C. Holzapfel, 1971, Biochimica et biophysica acta.

Broad scope secondary ion mass spectrometry

P. Williams, G. Cragg, C. Holzapfel, 1983 .

Solution-phase secondary-ion mass spectrometry of protonated amino acids.

G. Cragg, A. Tuinman, C. Holzapfel, 1987, Analytical biochemistry.

CROSS COUPLING STRATEGIES TOWARDS THE SYNTHESIS OF THE STREPTONIGRIN CD MOIETY

C. Holzapfel, C. Dwyer, R. Crous, 1999 .

Comparison of Anesthetic Potency of Benzocaine Hydrochloride and MS‐222 in Two Freshwater Fish Species

G. Smit, C. Holzapfel, H. Schoonbee, 1979 .

The Chiral Synthesis of Thiazole Amino Acid Enantiomers

C. Holzapfel, M. Bredenkamp, W. V. Zyl, 1990 .

The synthesis of ochratoxins A and B metabolites of Aspergillus ochraceus Wilh.

P. Steyn, C. Holzapfel, 1967, Tetrahedron.

Homo- and heteroditopic sulfur-based bidentate ligands towards selective ethylene oligomerisation: The critical influence of ligand structure on product profile

C. Holzapfel, M. C. Maumela, J. T. Dixon, 2017 .

Cyclopiamines A and B, novel oxindole metabolites of Penicillium cyclopium westling

J. Boeyens, P. Steyn, C. Holzapfel, 1979 .

Palladium-catalysed substitution reactions of geminal allylic diacetates

F. R. Heerden, C. Holzapfel, J. Huyser, 1998 .

Ethylene Tetramerisation: A Structure-Selectivity Correlation.

C. Holzapfel, J. Willemse, M. C. Maumela, 2020, ChemPlusChem.

Cyclopiamines A and B, novel oxindole metabolites of Penicillium cyclopium westling

J. Boeyens, P. Steyn, C. Holzapfel, 1979 .

The influence of process conditions on the competition between ethylene oligomerisation and polymerisation reactions with P,S-bidentate ligands

C. Holzapfel, M. C. Maumela, J. T. Dixon, 2018, Applied Catalysis A: General.

Palladium-catalysed cyclisation of chiral carbohydrate-derived geminal diacetates

C. Holzapfel, F. Toerien, L. Marais, 1999 .

The synthesis and conformation in solution of cyclo[L-pro-L-leu-(gln)thz-(gly)thz-L-val] (dolastatin 3)

C. Holzapfel, W. V. Zyl, M. Roos, 1990 .

The structure and synthesis of dolastatin 3

A. Tuinman, C. Holzapfel, Jean M. Schmidt, 1987 .

Synthesis of the modified dolastatin 3 sequence cyclo -[L-Val-L-Leu-L-Pro-(R ,S )-(gln)Thz-(gly)Thz]

C. Holzapfel, G. Pettit, 1986 .

Synthesis of the Dolastatin 3 Isomer cyclo-[L-Pro-L-Leu-L-Val-(-R,S)-(gln)Thz-(gly)Thz]

C. Holzapfel, G. Pettit, 1986 .

Synthesis of the cyclo-[(gly)Thz-(R)-and cyclo-[(gly)Thz-(S)-(gln)Thz-L-Val-L-Leu-L-Pro] isomers of dolastatin 3

P. S. Nelson, C. Holzapfel, G. Pettit, 1985 .

PALLADIUM-CATALYSED CYCLISATION AND FUNCTIONALISATION OF 1,1-DIACETOXY-2,7-DIENE AND 1,1-DIACETOXY-2-EN-7-YNE DERIVATIVES

C. Holzapfel, L. Marais, 1998 .

The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling.

C. Holzapfel, 1968, Tetrahedron.

Nitro-activated double bonds in Pd(0)-catalysed [3 + 2]-cycloaddition reactions

C. Holzapfel, T. L. V. D. Merwe, 1996 .

2-Nitroglycals Preparation and Nucleophilic Addition Reactions

C. Holzapfel, C. F. Marais, M. S. V. Dyk, 1988 .

Plicataloside, an O,O-diglycosylated naphthalene derivative from Aloe plicatilis

P. Wessels, C. Holzapfel, B. Wyk, 1996 .

ARYL γ-KETOESTERS AS PRECURSORS FOR γ-BUTYROLACTONE DIMERS IN SAMARIUM(II) IODIDE-MEDIATED REACTIONS

D. Williams, C. Holzapfel, Kevin Blann, 2002 .

Observations on the Hantzsch Reaction: Synthesis of N-tBoc-S-Dolaphenine

C. Holzapfel, M. Bredenkamp, W. V. Zyl, 1992 .

The Chiral Synthesis of Thiazole Amino Acid Enantiomers.

C. Holzapfel, M. Bredenkamp, W. V. Zyl, 1991 .

Synthesis of the dolastatin thiazole amino acid component (gln)Thz

C. Holzapfel, G. Pettit, 1985 .

Phosphine-Borane Complexes: in situ Deprotection and Application as Ligands in the Rh- or Pd-Catalysed Hydroformylation Reaction

D. Williams, A. Ferreira, P. D. R. Kotzé, 2011 .

THE CONVERSION OF GLUCOSE INTO AN EARLY ZINCOPHORIN SYNTHON

C. Holzapfel, Jozua F. Bocysen, 1995 .

Aluminum triflate as a highly active and efficient nonprotic cocatalyst in the palladium-catalyzed methoxycarbonylation reaction.

M. Shaw, D. Williams, C. Holzapfel, 2008, Angewandte Chemie.

A Simple Cycloaddition Approach to a Racemate of the Natural Sweetener Monatin

C. Holzapfel, K. Bischofberger, J. Olivier, 1994 .

A facile route to 3a,8a-dihydrofuro[2,3-b]benzofurans

C. Holzapfel, G. Williams, D. Bradley, 1995 .

ON A FACILE SYNTHESIS OF MELATONIN AND OTHER RELATED INDOLES

C. Holzapfel, W. Marais, 1998 .

Heck Reactions of Some Cyclic Enol Ethers: Intramolecular Trapping of Migratory Palladium

D. Williams, C. Holzapfel, 1994 .

Palladium Catalysed Tandem Allylic Substitution Methodology in the Synthesis of a Component of Civet

C. Holzapfel, F. Toerien, M. Bredenkamp, 1992 .

Palladium-catalyzed Heck reactions promoted by limonene-derived bicyclic phosphines

C. Holzapfel, Paseka T. Moshapo, M. C. Maumela, 2022, Synthetic Communications.

Palladium-catalysed [3 + 2]-cycloaddition reactions employing sulphonyl-activated unsaturated carbohydrate derivatives

C. Holzapfel, T. L. V. D. Merwe, 1996 .

Palladium-catalysed Cyclisation and Cyclisation–Carbonylation of Unsaturated C-Glycoside Derivatives. The Importance of Relative Stereochemistry

C. Holzapfel, L. Marais, 1998 .

Stereoselective palladium catalyzed cyclization on carbohydrate templates- a route to chiral cyclopentanes and some heterocyclic analogs

C. Holzapfel, G. Engelbrech, 1991 .

Palladium-Catalyzed Substitution Reactions of geminal Allylic Diacetates.

D. Williams, F. R. Heerden, C. Holzapfel, 1998 .

SYNTHESIS AND REACTIONS OF CHIRAL CYCLIC NITRONES DERIVED FROM D-RIBOSE

C. Holzapfel, R. Crous, 1998 .

THE NITRATION OF ELECTRON-RICH AROMATICS

C. Holzapfel, C. Dwyer, 1998 .

Stereoselective Thallium-induced Ring Contraction of Glycals

D. Williams, C. Holzapfel, D. H. Braithwaite, 1999 .

Palladium-catalysed cascade reactions of unsaturated carbohydrate derivatives. Synthesis of enantiopure tricyclic compounds

C. Holzapfel, L. Marais, 1997 .

Observations on Dibutylstannylene as Template for the Assembly of Macrocyclic Oligolactones

H. Flowers, C. Holzapfel, M. Bredenkamp, 1992 .

Alternative Syntheses of L-(-)-Oleandrose from L-Rhamnose1 Preparation of Glycals

C. Holzapfel, F. Toerien, M. Bredenkamp, 1992 .

Antineoplastic agents. Par 108. Structural biochemistry. Part 23. Synthesis of the dolastatin thiazole amino acid component (gln)Thz

C. Holzapfel, G. Pettit, 1985 .

Macrocyclisation: The tin directed reaction of a carbohydrate derivative with succinyl chloride

C. Holzapfel, M. Bredenkamp, M. M. Basson, 1989 .

Palladium-Catalyzed Borylation of Aryl Bromides and Chlorides using Phosphatrioxa-adamantane Ligands

C. Holzapfel, Jairus L. Lamola, Paseka T. Moshapo, 2021, Tetrahedron Letters.

Branched Selectivity in the Pd‐Catalysed Methoxycarbonylation of 1‐Alkenes

C. Holzapfel, T. Bredenkamp, Charmaine Arderne, 2016 .

Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions

C. Holzapfel, Jairus L. Lamola, Paseka T. Moshapo, 2021, RSC advances.

Macrocyclization: The Tin Directed Reaction of a Carbohydrate Derivative with Succinyl Chloride.

C. Holzapfel, M. Bredenkamp, M. M. Basson, 1989 .

The Synthesis of Viridamine, A Penicillium Viridicatum Mycotoxin

C. Holzapfel, M. Bredenkamp, R. Bond, 1989 .

Furanoterpenoids from Siphonochilus aethiopicus.

P. Wessels, C. Holzapfel, B. Van Wyk, 2002, Phytochemistry.

Survev of Kaurene Derivatives in the Genus Alepidea ( Apiaceaej

Marais, A. Castro, C. Holzapfel, 2003 .

A chemotaxonomic survey of kaurene derivatives in the genus Alepidea (Apiaceae)

A. Castro, C. Holzapfel, B. Wyk, 1995 .

Furanoterpenoids from Siphonochilus aethiopicus

P. Wessels, C. Holzapfel, B. Wyk, 2002 .

Chromone and aloin derivatives from Aloe broomii, A. Africana and A. speciosa

P. Wessels, C. Holzapfel, B. Wyk, 1997 .

The isolation and structure of two new indole derivatives from Penicillium cyclopium westling.

D. Wilkins, C. Holzapfel, R. Hutchison, 1970, Tetrahedron.

The toxicity and chemical assay of sterigmatocystin, a carcinogenic mycotoxin, and its isolation from two new fungal sources.

I. Purchase, P. Steyn, C. Holzapfel, 1966, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Isolation and structure of aflatoxins M1 and M2.

I F Purchase, I. Purchase, P. Steyn, 1966, Tetrahedron letters.

Nystatin. Part V. Biosynthetic definition of some structural features

C. Djerassi, M. Suzuki, J. Dutcher, 1964 .

Nystatin. Part VI. Chemistry and partial structure of the antibiotic

C. Djerassi, M. Suzuki, J. Dutcher, 1964 .

On the biosynthesis of cyclopiazonic acid

D. Wilkins, C. Holzapfel, 1971 .

Direct transformation of steroidal ethers into ketones by dimethyldioxirane

F. R. Heerden, C. Holzapfel, J. T. Dixon, 1992 .

Selective Oxidation of Unactivated 5β C-H Bonds in Steroids by Dimethyldioxirane

F. R. Heerden, C. Holzapfel, J. T. Dixon, 1993 .

The Effects of SCILL Catalyst Modification on the Competitive Hydrogenation of 1‐Octyne and 1,7‐Octadiene versus 1‐Octene

H. Friedrich, C. Holzapfel, Stuart F. Miller, 2012 .

STEREOSELECTIVE SMI2-MEDIATED CONVERSION OF CARBOHYDRATES INTO CYCLOPENTANOLS

D. Williams, C. Holzapfel, J. J. CronjéGrové, 1996 .

Samarium (II) iodide mediated transformations of carbohydrate derived iodo oxime ethers into stereodefined alkoxy aminocyclopentanes

C. Holzapfel, J. J. Cronje, 1997 .

One-pot SmI2-promoted transformation of carbohydrate derivatives into cyclopentanols

D. Williams, C. Holzapfel, J. J. CronjéGrové, 1996 .

Stereoselective SmI2-Mediated Conversion of Carbohydrates into Cyclopentanols.

D. Williams, C. Holzapfel, J. Grové, 1996 .

A New Facile Synthesis of a Thromboxane B2 Precursor

C. Holzapfel, J. F. Booysen, 1995 .

Palladium Assisted Synthesis of a Thromboxane B2 Precursor

C. Holzapfel, G. Verdoorn, M. M. Basson, 1989 .

Stannylene directed selective acylation of some open-chain L-arabinose derivatives

C. Holzapfel, M. Bredenkamp, A. D. Swanepoel, 1990 .

A Facile Preparation of Pyridine- and Quinoline-Carboxaldehydes by Palladium Catalysed Carbonylation †

C. Holzapfel, Alta C. Ferreira, W. Marais, 2002 .

Photochemical oxidation of partially protected derivatives of α-d-glucofuranose and β-d-fructofuranose

C. Holzapfel, G. Kruger, L. D. Drijver, 1987 .

Palladium-Assisted Synthesis of a Thromboxane B2 Precursor.

C. Holzapfel, G. Verdoorn, M. M. Basson, 1990 .

A New Facile Synthesis of a Thromboxane B2 Precursor.

C. Holzapfel, J. F. Booysen, 1995 .

Palladium Catalyzed Reactions of Unsaturated Carbohydrates — A Route to C-Glycosides

C. Holzapfel, G. J. Engelbrecht, 1991 .

The facile conversion of pyranoid glycals into 2-deoxy-glycosidic orthoesters

C. Holzapfel, G. J. Engelbrecht, G. Verdoorn, 1989 .

Preparation of an analogue of orbicuside A, an unusual cardiac glycoside

F. R. Heerden, C. Holzapfel, J. T. Dixon, 2005 .

Stannylene‐Directed Selective Acylation of Some Open‐Chain L‐Arabinose Derivatives.

C. Holzapfel, M. Bredenkamp, A. D. Swanepoel, 1991 .

An Efficient Synthesis of Dicarbonyl (η5—Cyclopentadien—YL)Iron(II) Complexes of Two Cyclic Enol Ethers

C. Holzapfel, M. Bredenkamp, J. F. Booysen, 1989 .

An Efficient Synthesis of Dicarbonyl(η5-cyclopentadienyl)iron(II) Complexes of Two Cyclic Enol Ethers.

C. Holzapfel, M. Bredenkamp, J. F. Booysen, 1990 .

Palladium(II)-catalysed Intramolecular Oxypalladation/Functionalisation of Carbohydrate-derived Cyclic Alkenes. Regioselective Formation of Substituted Di- and Tetra-hydropyrans

C. Holzapfel, L. Marais, 1999 .

The Synthesis of a γ-Keto-α-amino Acid, a Key Intermediate in the Synthesis of Monatin, a New Natural Sweetener

C. Holzapfel, J. Olivier, 1993 .

A New Method for Selective Protection of Two Hydroxyl Groups in Carbohydorates, Glycals in Particular

F. R. Heerden, C. Holzapfel, T. L. V. D. Merwe, 1991 .

O-NITROPHENYLTRIFLATES IN QUINOLINE SYNTHESIS : EASY ACCESS TO A STREPTONIGRIN SYNTHON

C. Holzapfel, C. Dwyer, 1998 .

Application of P ‐Bridged Biaryl Phosphines in Pd‐Catalyzed α ‐Arylation Reactions

C. Holzapfel, Jairus L. Lamola, Paseka T. Moshapo, 2022, ChemistrySelect.

The isolation and structure of a new diterpene lactone from Trichothecium roseum link

P. Steyn, C. Holzapfel, 1968 .

10 – The Biosynthesis of Cyclopiazonic Acid and Related Tetrantic Acids

C. Holzapfel, 1980 .

The Stereospecific Synthesis of a Synthon for 11-Deoxy-11-thiaprostanoids from Carbohydrates

C. Holzapfel, G. Verdoorn, A. D. Swanepoel, 1989 .

The structure and biogenesis of desoxyverrucarin E, a metabolite of Eupenicillium hirayamae

C. Holzapfel, R. R. Arndt, N. P. Ferreira, 1974 .

A Facile Route to Steroidal 6-Deoxy-α-L-allopyranosides

F. R. Heerden, C. Holzapfel, J. T. Dixon, 1998 .

A Facile Route to Steroidal 6-Deoxy-α-L-allopyranosides.

F. R. Heerden, C. Holzapfel, J. T. Dixon, 1998 .

Effects of Organic Modifiers on a Palladium Catalyst in the Competitive Hydrogenation of 1‐Octene Versus Octanal: An Evaluation of Solid Catalysts with an Ionic Liquid Layer

V. Dasireddy, H. Friedrich, C. Holzapfel, 2015 .

The Pd-catalysed hydromethoxycarbonylation of aliphatic internal alkenes with minimal double bond isomerisation

C. Holzapfel, T. Bredenkamp, 2017 .

A COMPARATIVE STUDY OF SOME Pd-CATALYSED HECK REACTIONS IN POLAR- AND AQUEOUS BIPHASIC MEDIA

C. Holzapfel, H. Lombard, D. Williams, 2001 .

Efficient system for facile access to ortho-substituted aryl boronates through palladium-catalysed borylation

C. Holzapfel, Banothile C. E. Makhubela, Jairus L. Lamola, 2023, Tetrahedron Letters.

Structures of 3-cyanohexahydronaphth-[2,3-e]-1,2-oxazines part 3: Comparison of the conformations of some 3-cyanotetrahydro-1, 2-oxazine ring systems

C. Holzapfel, G. Kruger, M. S. V. Dyk, 1987 .

A study of the mutagenicity of irradiated sugar solutions: implications for the radiation preservation of subtropical fruits.

C. Holzapfel, H. J. van der Linde, J. Niemand, 1983, Journal of agricultural and food chemistry.

(Acetato-κ2 O,O′)[2′-(di-tert-butylphosphanyl)-1,1′-biphenyl-κ2 P,C 2]palladium(II)

C. Holzapfel, Charmaine Arderne, 2012, Acta crystallographica. Section E, Structure reports online.

Bis[(1,1′-biphenyl-2,2′-diyl)di-tert-butylphosphonium] di-μ-chlorido-bis[dichloridopalladate(II)]

C. Holzapfel, Charmaine Arderne, 2012, Acta crystallographica. Section E, Structure reports online.

Cyclopiamide, an isoindolo[4,6-cd]indole from Penicillium cyclopium

J. Boeyens, C. Holzapfel, M. Bredenkamp, 1990 .