W. Chiou

发表

Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.

K. Longenecker, Jyoti R. Patel, H. Sham, 2007, Bioorganic & medicinal chemistry letters.

Azole endothelin antagonists. 2. Structure-activity studies.

J. R. Wu-wong, W. Chiou, T. V. Geldern, 1996, Journal of medicinal chemistry.

Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.

Deanne F. Stolarik, S. Fung, Katina Monzon, 2006, Bioorganic & medicinal chemistry letters.

Quantitation of Plasma Membrane Drug Transporters in Kidney Tissue and Cell Lines Using a Novel Proteomic Approach Enabled a Prospective Prediction of Metformin Disposition

S. D. de Morais, Kenneth R. Durbin, J. P. Savaryn, 2021, Drug Metabolism and Disposition.

Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist.

S. Magnuson, K. Marsh, J. R. Wu-wong, 1996, The Journal of pharmacology and experimental therapeutics.

The effects of diminishing albumin binding to some Endothelin receptor antagonists.

K. Marsh, J. R. Wu-wong, W. Chiou, 1998, Life sciences.

No Inhibition of MATE1/2K-Mediated Renal Creatinine Secretion Predicted With Ritonavir or Cobicistat.

S. D. de Morais, W. Chiou, R. Kikuchi, 2019, Journal of pharmaceutical sciences.

Microarrayed Compound Screening (μARCS) to Identify Activators and Inhibitors of AMP-Activated Protein Kinase

P. Richardson, D. Egan, J. Kofron, 2004, Journal of biomolecular screening.

The electroreduction of several metallo-octakis(methylthio)tetraazaporphyrins

L. Bottomley, W. Chiou, 1986 .

Endothelin Stimulates Glucose Uptake and GLUT4 Translocation via Activation of Endothelin ETA Receptor in 3T3-L1 Adipocytes*

J. R. Wu-wong, W. Chiou, Jiahong Wang, 1999, The Journal of Biological Chemistry.

Endothelin attenuates apoptosis in human smooth muscle cells.

J. R. Wu-wong, W. Chiou, T. Opgenorth, 1997, The Biochemical journal.

Two signal transduction pathways mediate interleukin-1 receptor expression in Balb/c3T3 fibroblasts.

W. Chiou, P. Bonin, J. Mcgee, 1990, The Journal of biological chemistry.

Platelet-derived growth factor induces interleukin-1 receptor gene expression in Balb/c 3T3 fibroblasts.

W. Chiou, P. Harris, D. Carter, 1989, The Journal of biological chemistry.

Simultaneous quantification of malonyl-CoA and several other short-chain acyl-CoAs in animal tissues by ion-pairing reversed-phase HPLC/MS.

Hua Tang, D. Burns, Xueheng Cheng, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722.

A. Tasker, K. Marsh, J. R. Wu-wong, 1996, Journal of medicinal chemistry.

Quantitative measurements of corticosteroids in ex vivo samples using on-line SPE-LC/MS/MS.

D. Burns, Xueheng Cheng, Lan Gao, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors

K. Longenecker, R. Judge, Deanne F. Stolarik, 2007 .

Characterization of two endothelin converting enzymes and their preference for big endothelin-1 and -2 as substrates.

A. Tasker, J. R. Wu-wong, W. Chiou, 1994, Life sciences.

Extracellular signal-regulated kinases are involved in the antiapoptotic effect of endothelin-1.

J. R. Wu-wong, W. Chiou, J. Wang, 2000, The Journal of pharmacology and experimental therapeutics.

Direct determination of endothelin receptor antagonist levels in plasma using a scintillation proximity assay.

J. R. Wu-wong, B. Dayton, W. Chiou, 2000, Life sciences.

SV40 virus transformation down-regulates endothelin receptor.

J. R. Wu-wong, W. Chiou, J. Wang, 1999, Biochimica et biophysica acta.

Pharmacology of A-216546: a highly selective antagonist for endothelin ET(A) receptor.

K. Marsh, J. Wu-Wong, B. Dayton, 1999, European journal of pharmacology.

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies.

A. Tasker, J. R. Wu-wong, M. Winn, 2002, Clinical science.

'Irreversible' endothelin-1 binding does not prohibit ABT-627 from reversing endothelin-1-induced effects.

J. R. Wu-wong, W. Chiou, J. Wessale, 2000, Journal of cardiovascular pharmacology.

Internalization of type-A endothelin receptor.

J. R. Wu-wong, W. Chiou, G. Gagné, 2000, Journal of cardiovascular pharmacology.

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET(A) receptor selectivity.

A. Tasker, K. Marsh, C. Hutchins, 1999, Bioorganic & medicinal chemistry.

Dissociation characteristics of endothelin receptor agonists and antagonists in cloned human type-B endothelin receptor.

S. Magnuson, J. R. Wu-wong, W. Chiou, 1997, Endothelium : journal of endothelial cell research.

Human astrocytoma U138MG cells express predominantly type-A endothelin receptor.

S. Magnuson, J. R. Wu-wong, B. Bianchi, 1996, Biochimica et biophysica acta.

Endothelins and endothelin receptor antagonists: binding to plasma proteins.

J. R. Wu-wong, M. Winn, W. Chiou, 1996, Life sciences.

Endothelin receptor agonists and antagonists exhibit different dissociation characteristics.

S. Magnuson, J. R. Wu-wong, W. Chiou, 1994, Biochimica et biophysica acta.

Endothelin receptor antagonists exhibit diminishing potency following incubation with agonist.

J. R. Wu-wong, W. Chiou, T. Opgenorth, 1994, Life sciences.

Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators.

L. Kifle, H. Sham, P. Kym, 2007, Bioorganic & medicinal chemistry letters.

Endothelin receptor in human astrocytoma U373MG cells: binding, dissociation, receptor internalization.

S. Magnuson, J. R. Wu-wong, W. Chiou, 1995, The Journal of pharmacology and experimental therapeutics.

Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.

R. Henry, H. Sham, D. Beno, 2007, Journal of medicinal chemistry.

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models.

S. Rosenberg, S. L. Gwaltney, R. B. Credo, 2001, Journal of medicinal chemistry.

Discovery of orally active butyrolactam 11β-HSD1 inhibitors

E. Bush, Deanne F. Stolarik, S. Fung, 2006 .

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists.

K. Marsh, M. Winn, W. Chiou, 2001, Journal of medicinal chemistry.

Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.

Jyoti R. Patel, H. Sham, S. Fung, 2006, Bioorganic & medicinal chemistry letters.

A possible role for dephosphorylation in glucocorticoid receptor transformation.

W. Chiou, W. Vedeckis, M. Lapointe, 1987, Journal of steroid biochemistry.

Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.

A. Tasker, K. Marsh, B. Dayton, 1997, Journal of medicinal chemistry.

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

L. Kifle, Gang Zhao, K. Marsh, 2006, Cell metabolism.

Validation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions

S. D. de Morais, W. Chiou, R. Kikuchi, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia

S. D. de Morais, Xiaofen Li, R. Voorman, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Oxidant-induced activation of protein kinase C in UC11MG cells.

K. Leach, W. Chiou, K L Leach, 1995, Free radical research.

Dissociation Characteristics of Endothelin ETA Receptor Agonists and Antagonists

J. R. Wu-wong, W. Chiou, D. Dixon, 1995, Journal of cardiovascular pharmacology.

Prediction of clinical drug-drug interactions of veliparib (ABT-888) with human renal transporters (OAT1, OAT3, OCT2, MATE1, and MATE2K).

S. D. de Morais, R. Voorman, W. Chiou, 2013, Journal of pharmaceutical sciences.

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity.

A. Tasker, K. Marsh, M. Winn, 1999, Journal of Medicinal Chemistry.

Endothelin receptor antagonists: effect of serum albumin on potency and comparison of pharmacological characteristics.

J. Wu-Wong, W. Chiou, J R Wu-Wong, 1997, The Journal of pharmacology and experimental therapeutics.

Azole endothelin antagonists. 3. Using delta log P as a tool to improve absorption.

K. Marsh, J. R. Wu-wong, B. Dayton, 1996, Journal of medicinal chemistry.

Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain.

K. Marsh, M. Winn, W. Chiou, 1999, Journal of medicinal chemistry.

Endothelin receptor in benign prostatic hyperplastic cells. Binding and functional studies.

S. Magnuson, S. Ng, J. R. Wu-wong, 1997, Receptors & signal transduction.

Obligatory action of polypeptide growth factors for the IL-1-mediated prostaglandin E2 production in fibroblasts. Potential role of growth factors in modulation of tissue response to IL-1.

W. Chiou, P. Bonin, J. Singh, 1990, Journal of immunology.

Azole endothelin antagonists. 1. A receptor model explains an unusual structure-activity profile.

C. Hutchins, J. R. Wu-wong, W. Chiou, 1996, Journal of medicinal chemistry.

Endothelin receptors in human smooth muscle cells: antagonist potency differs on agonist-evoked responses.

J. R. Wu-wong, W. Chiou, T. Opgenorth, 1994, The American journal of physiology.

Identification and characterization of A-105972, an antineoplastic agent.

D. Burns, S. Tahir, L. Alder, 2001, Cancer research.

Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.

Jyoti R. Patel, H. Sham, D. Beno, 2006, Bioorganic & medicinal chemistry letters.

Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.

K. Longenecker, R. Judge, Deanne F. Stolarik, 2007, Bioorganic & medicinal chemistry letters.

Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.

E. Bush, Deanne F. Stolarik, S. Fung, 2006, Bioorganic & medicinal chemistry letters.

In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia

S. D. de Morais, Xiaofen Li, R. Voorman, 2014, Xenobiotica; the fate of foreign compounds in biological systems.