A. Sudom

发表

Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.

N. Walker, Hiroshi Yamamoto, Zhulun Wang, 2008, Bioorganic & medicinal chemistry.

Structure/function studies of phosphoryl transfer by phosphoenolpyruvate carboxykinase.

L. Prasad, L. Delbaere, H. Goldie, 2004, Biochimica et biophysica acta.

Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2009, Bioorganic & medicinal chemistry letters.

Structural Characterization and Pharmacodynamic Effects of an Orally Active 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor

Zhulun Wang, Haoda Xu, Xiaoshan Min, 2007, Chemical biology & drug design.

Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4.

N. Walker, Z. Cao, Zhulun Wang, 2015, Bioorganic & medicinal chemistry letters.

Cytotoxic activities of Mannich bases of chalcones and related compounds.

T. Myers, E. De Clercq, J. Quail, 1998, Journal of medicinal chemistry.

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.

N. Walker, Zhulun Wang, Jinsong Liu, 2010, Bioorganic & medicinal chemistry letters.

Mechanisms of Activation of Phosphoenolpyruvate Carboxykinase from Escherichia coli by Ca2+ and of Desensitization by Trypsin

L. Prasad, L. Delbaere, H. Goldie, 2003, Journal of bacteriology.

The phosphoryl-transfer mechanism of Escherichia coli phosphoenolpyruvate carboxykinase from the use of AlF(3).

L. Prasad, L. Delbaere, H. Goldie, 2001, Journal of molecular biology.

Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation

I. D'Angelo, Xiaoshan Min, I. Foltz, 2021, The Journal of biological chemistry.

4-(beta-Arylvinyl)-3-(beta-arylvinylketo)-1-ethyl-4-piperidinols and related compounds: a novel class of cytotoxic and anticancer agents.

E. De Clercq, J. Quail, J. Dimmock, 1998, Journal of medicinal chemistry.

Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

N. Walker, Z. Cao, O. Plotnikova, 2012, The Journal of Biological Chemistry.

Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.

N. Walker, Zhulun Wang, Jinsong Liu, 2006, Structure.

Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.

O. Plotnikova, Zhulun Wang, Jinsong Liu, 2013, Bioorganic & medicinal chemistry letters.

Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2

A. Lim, Zhongqi Zhang, Zhulun Wang, 2018, Journal of Biological Chemistry.

Structure-function studies of the phosphoryl-transfer enzyme: phosphoenolpyruvate carboxykinase

L. Prasad, H. Goldie, A. Sudom, 2003 .

An Inhibitory Antibody against Dipeptidyl Peptidase IV Improves Glucose Tolerance in Vivo

N. Walker, P. Cao, Zhulun Wang, 2012, The Journal of Biological Chemistry.

Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.

Yang Li, Peter Coward, Alex Zhang, 2009, Bioorganic & medicinal chemistry letters.

AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys.

T. Arvedson, P. Bogner, M. Friedrich, 2020, Blood advances.

Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.

M. Monshouwer, N. Walker, R. Hungate, 2008, Journal of medicinal chemistry.

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).

N. Walker, Zhulun Wang, Jinsong Liu, 2009, Bioorganic & medicinal chemistry letters.

Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

N. Walker, Zhulun Wang, S. Miao, 2008, Bioorganic & Medicinal Chemistry Letters.

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2011, Bioorganic & medicinal chemistry letters.

Next generation Fc scaffold for multispecific antibodies

D. Gong, D. Whittington, Zhulun Wang, 2021, iScience.