Daqing Sun

发表

Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.

N. Walker, Hiroshi Yamamoto, Zhulun Wang, 2008, Bioorganic & medicinal chemistry.

Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors

Tianxin Yang, J. Schnermann, J. Briggs, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).

N. Jahchan, E. Jackson, J. Medina, 2018, Journal of medicinal chemistry.

Pharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2–p53 interaction, in rats, dogs and monkeys: in vitro–in vivo correlation

Min Jiang, B. Wong, S. Olson, 2015, Xenobiotica; the fate of foreign compounds in biological systems.

KatG and KatE confer Acinetobacter resistance to hydrogen peroxide but sensitize bacteria to killing by phagocytic respiratory burst.

Yusen Liu, K. Mason, Daqing Sun, 2016, Life sciences.

Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2009, Bioorganic & medicinal chemistry letters.

Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4.

N. Walker, Z. Cao, Zhulun Wang, 2015, Bioorganic & medicinal chemistry letters.

Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.

Sean P. Brown, A. Cheng, D. Whittington, 2019, Journal of medicinal chemistry.

Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633).

N. Jahchan, J. Medina, V. Fantin, 2019, Journal of medicinal chemistry.

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.

Y. Wang, J. Canon, J. Oliner, 2014, Journal of medicinal chemistry.

Polyene Cyclization Promoted by the Cross Conjugated α‐Carbalkoxy Enone System. An Efficient Approach to Highly Functionalized Decalins

Kak‐Shan Shia, Daqing Sun, Hsing‐Jang Liu, 1999 .

Polyene cyclization promoted by the cross conjugated a-carbalkoxy enone system

Kak‐Shan Shia, Daqing Sun, Hsing‐Jang Liu, 1996 .

Synthetic studies on clerodane diterpenoids. The total synthesis of (±)-2-oxo-5α,8α-13,14,15,16-tetranorclerod-3-en-12-oic acid

Kak‐Shan Shia, Daqing Sun, Yu Wang, 1997 .

Stereoselective production of β-amino alcohols and β-thioacyl alcohols via an application of the non-aldol aldol process

M. Jung, Daqing Sun, 1999 .

An Efficient and Scalable One-Pot Double Michael Addition-Dieckmann Condensation for the Synthesis of 4,4-Disubstituted Cyclohexane β-Keto Esters

R. Hungate, J. Powers, D. McMinn, 2007 .

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.

N. Walker, Zhulun Wang, Jinsong Liu, 2010, Bioorganic & medicinal chemistry letters.

Polyene Cyclization Promoted by the Cross Conjugated α-Carbalkoxy Enone System. Application to the Total Synthesis of (±)-Dehydrochamaecynenol

Daqing Sun, Hsing‐Jang Liu, 1997 .

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Y. Wang, J. Canon, M. Peterson, 2014, Journal of medicinal chemistry.

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

J. Canon, J. Oliner, Xin Huang, 2014, Journal of medicinal chemistry.

Genome, transcriptome and fermentation analyses of Lactobacillus plantarum LY-78 provide new insights into the mechanism of phenyllactate biosynthesis in lactic acid bacteria.

Liping Zhang, Daqing Sun, Dawei Song, 2019, Biochemical and biophysical research communications.

Rational design and binding mode duality of MDM2-p53 inhibitors.

Xin Huang, Paul Shaffer, Steve Schneider, 2013, Journal of medicinal chemistry.

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.

J. Canon, J. Oliner, Xin Huang, 2014, Journal of medicinal chemistry.

Abstract 4172: Activation of AR signaling by mifepristone enhances prostate cancer growth and impairs enzalutamide response

Mallika Singh, E. Jackson, J. Medina, 2017 .

Regulation of cyclooxygenase expression in the kidney by dietary salt intake.

Tianxin Yang, J. Schnermann, J. Briggs, 1998, American journal of physiology. Renal physiology.

Orally Bioavailable Small Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression Through Blockade of Adenosine Production.

L. Friedman, M. Junttila, V. Fantin, 2020, Journal of medicinal chemistry.

Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer.

Daqing Sun, Y. Rew, 2014, Journal of medicinal chemistry.

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

J. Canon, J. Oliner, Min Jiang, 2012, Journal of medicinal chemistry.

Differential regulation of COX-2 expression in the kidney by lipopolysaccharide: role of CD14.

Tianxin Yang, J. Schnermann, J. Briggs, 1999, American journal of physiology. Renal physiology.

Microbiota diversity, composition and drivers in waxy proso millet sourdoughs of Niandoubao, a traditional fermented cereal food in northeast China

Daqing Sun, Hongfei Li, Hongfei Li, 2023, LWT.

Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.

M. Monshouwer, N. Walker, R. Hungate, 2008, Journal of medicinal chemistry.

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.

Xin Huang, Paul Shaffer, Daqing Sun, 2014, ACS medicinal chemistry letters.

Synthesis, in Vitro Covalent Binding Evaluation, and Metabolism of (14)C-Labeled Inhibitors of 11β-HSD1.

M. Monshouwer, Min Jiang, J. Powers, 2014, ACS medicinal chemistry letters.

Small molecule 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Zhulun Wang, Minghan Wang, Daqing Sun, 2011, Current Topics in Medicinal Chemistry.

Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors.

J. Jaén, J. Powers, D. McMinn, 2012, Bioorganic & medicinal chemistry letters.

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).

N. Walker, Zhulun Wang, Jinsong Liu, 2009, Bioorganic & medicinal chemistry letters.

Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

N. Walker, Zhulun Wang, S. Miao, 2008, Bioorganic & Medicinal Chemistry Letters.

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2011, Bioorganic & medicinal chemistry letters.

Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1).

Daqing Sun, 2008 .