L. Hardegger

发表

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

Nobuo Shimma, François Diederich, Jörg Benz, 2011, ChemMedChem.

Systematic investigation of halogen bonding in protein-ligand interactions.

François Diederich, Jörg Benz, Bernd Kuhn, 2011, Angewandte Chemie.

New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates.

F. Diederich, W. Schweizer, L. Hardegger, 2009, Organic & biomolecular chemistry.

Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation.

T. Donohoe, L. Hardegger, Jacqueline Habegger, 2015, Organic letters.

Self-association based on orthogonal C=O...C=O interactions in the solid and liquid state.

F. Diederich, M. Ebert, W. Schweizer, 2010, Chemical communications.

Title Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

J. Sivak, Fupeng Ma, P. Tarsa, 2018 .

Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2015, Journal of medicinal chemistry.

Toward a Scalable Synthesis and Process for EMA401, Part II: Development and Scale-Up of a Pyridine- and Piperidine-Free Knoevenagel–Doebner Condensation

L. Hardegger, Eric Sidler, Roger Humair, 2020 .

Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.

François Diederich, Bernd Kuhn, F. Diederich, 2016, Chemistry.

Toward a Scalable Synthesis and Process for EMA401, Part III: Using an Engineered Phenylalanine Ammonia Lyase Enzyme to Synthesize a Non-natural Phenylalanine Derivative

Christian Fleury, A. Udvarhelyi, L. Hardegger, 2020 .

Toward a Scalable Synthesis and Process for EMA401, Part I: Late Stage Process Development, Route Scouting, and ICH M7 Assessment

L. Hardegger, Lei Shi, A. Grand-Guillaume Perrenoud, 2020 .

The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2018, Journal of medicinal chemistry.

Enantiomerically Pure and Highly Substituted Alicyclic α,α‐Difluoro Ketones: Potential Inhibitors for Malarial Aspartic Proteases, the Plasmepsins

F. Diederich, L. Hardegger, D. Bur, 2010 .

New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates.

F. Diederich, L. Hardegger, D. Bur, 2009, Organic & biomolecular chemistry.