N. Shimma

发表

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

Nobuo Shimma, François Diederich, Jörg Benz, 2011, ChemMedChem.

Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning.

M. Sakaitani, K. Morikami, N. Shimma, 2014, ACS medicinal chemistry letters.

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.

C. Lukacs, C. Janson, C. Belunis, 2011, Bioorganic & medicinal chemistry letters.

A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. I. Taxonomy, fermentation, isolation and structural elucidation.

H. Kotaki, N. Shimma, T. Ohtsuka, 1992, The Journal of antibiotics.

A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts

H. Yamada-Okabe, S. Niizuma, N. Shimma, 2009, Cancer Chemotherapy and Pharmacology.

Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole.

M. Sakaitani, Y. Isshiki, N. Shimma, 2003, Bioorganic & medicinal chemistry letters.

The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.

H. Ishitsuka, I. Horii, N. Shimma, 2000, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors.

Y. Isshiki, N. Shimma, M. Sudoh, 2000, Bioorganic & medicinal chemistry letters.

Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp. NR0489. II. Isolation, characterization and biological activities.

H. Kotaki, M. Arisawa, H. Seto, 1993, The Journal of antibiotics.

Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp.

H. Kotaki, H. Seto, N. Shimma, 1992, The Journal of antibiotics.

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase.

K. Kawasaki, S. Sogabe, K. Morikami, 2003, Bioorganic & medicinal chemistry.

Case Study: Capecitabine: A Prodrug of 5-Fluorouracil

N. Shimma, 2007 .

Piperazine propanol derivative as a novel antifungal targeting 1,3-beta-D-glucan synthase.

Y. Ohya, M. Arisawa, M. Sakaitani, 2005, Biological & pharmaceutical bulletin.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.

S. Niizuma, K. Kawasaki, S. Sogabe, 2003, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1.

K. Kawasaki, S. Sogabe, N. Shimma, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1.

T. Watanabe, Y. Satoh, I. Horii, 2001, Bioorganic & medicinal chemistry letters.

Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889

H. Ishitsuka, N. Shimma, T. Ishikawa, 2003, International journal of cancer.

Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.

H. Ishitsuka, I. Horii, N. Shimma, 2003, Bioorganic & medicinal chemistry letters.

5a-Carba-β-D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Motohiro Kato, M. Ohmori, N. Shimma, 2011, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors.

M. Sakaitani, T. Fukami, N. Shimma, 2009, Bioorganic & medicinal chemistry letters.

Identification of a Novel Inhibitor Specific to the Fungal Chitin Synthase

M. Arisawa, N. Shimma, M. Sudoh, 2000, The Journal of Biological Chemistry.

Letter to the Editor: Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII

N. Shimma, Takaaki Miura, Y. Shiratori, 2003, Journal of biomolecular NMR.

Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties.

Noriyuki Furuichi, Masahiro Sakaitani, Nobuo Shimma, 2013, ACS medicinal chemistry letters.

The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors.

M. Sakaitani, N. Shimma, Y. Aoki, 2013, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.

S. Niizuma, K. Kawasaki, S. Sogabe, 2003, Bioorganic & medicinal chemistry letters.

Miscellaneous Functional Groups

J. Tilley, N. Shimma, 2007 .

Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors.

Shigeo Sato, Sung-jin Kim, K. Kawasaki, 2014, Bioorganic & medicinal chemistry.

Hispidospermidin, a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. II. Isolation, characterization and structural elucidation.

H. Seto, N. Shimma, T. Ohtsuka, 1994, The Journal of antibiotics.

In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.

M. Page, M. Arisawa, Kazuko Kobayashi, 2010, International journal of antimicrobial agents.

Modeling, synthesis and biological activity of novel antifungal agents (1).

N. Shimma, K. Hattori, Y. Shiratori, 1998, Bioorganic & medicinal chemistry letters.

Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals.

N. Shimma, S. Ichihara, I. Umeda, 2002, Bioorganic & medicinal chemistry letters.

Structure of a novel phospholipase C inhibitor, vinaxanthone (Ro 09-1450), produced by penicillium vinaceum

H. Seto, N. Shimma, M. Aoki, 1991 .

Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp. NR0489. III. Structural elucidation.

H. Seto, N. Shimma, T. Ohtsuka, 1993, The Journal of antibiotics.

Host sphingolipid biosynthesis as a target for hepatitis C virus therapy

M. Aoki, M. Arisawa, M. Kohara, 2005, Nature chemical biology.

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.

H. Ishitsuka, N. Shimma, N. Sawada, 1998, European journal of cancer.

Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation.

H. Koyano, T. Ishikawa, N. Shimma, 2012, Bioorganic & medicinal chemistry.

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799.

Miyuki Yoshida, K. Morikami, N. Shimma, 2011, Bioorganic & medicinal chemistry letters.

Penitricin, a new class of antibiotic produced by Penicillium aculeatum. III. Structural confirmation by chemical synthesis and biological activity.

T. Furumai, T. Okuda, N. Shimma, 1984, The Journal of antibiotics.

Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents.

Miyuki Yoshida, K. Morikami, N. Shimma, 2016, Bioorganic & medicinal chemistry.

Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation.

Nobuo Shimma, Kenji Morikami, Miyuki Yoshida, 2013, Bioorganic & medicinal chemistry letters.

Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.

N. Rosen, T. Sakai, M. Arisawa, 2013, Cancer research.

An orally available, small-molecule interferon inhibits viral replication

M. Arisawa, Y. Hirata, M. Kohara, 2012, Scientific Reports.

Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog.

S. Niizuma, Kazuko Kobayashi, N. Shimma, 2009, Bioorganic & medicinal chemistry letters.

Enantioselective synthesis of derivatives and structure-activity relationship study in the development of NA255 as a novel host-targeting anti-HCV agent.

M. Aoki, H. Sakamoto, K. Kawasaki, 2013, Bioorganic & medicinal chemistry letters.

Synthesis of new camptothecin analogs with improved antitumor activities.

S. Niizuma, Kazuko Kobayashi, K. Morikami, 2009, Bioorganic & medicinal chemistry letters.

3D-QSAR study of antifungal N-myristoyltransferase inhibitors by comparative molecular surface analysis

Nobuo Shimma, Yasuhiko Shiratori, Tatsuo Ohtsuka, 2003 .

Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors.

F. Winkler, D. Banner, A. D'arcy, 2002, Chemistry & biology.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2.

K. Kawasaki, S. Sogabe, K. Morikami, 2002, Bioorganic & medicinal chemistry letters.

Cassette Dosing Approach and Quantitative Structure-Pharmacokinetic Relationship Study of Antifungal N-Myristoyltransferase Inhibitors

Kiyoshi Hasegawa, Yuko Aoki, Nobuo Shimma, 2002, J. Chem. Inf. Comput. Sci..

Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.

Sung-jin Kim, K. Hasegawa, T. Fukami, 2011, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.

Atsushi Suda, Hiroshi Koyano, Naomi Ono, 2012, Bioorganic & medicinal chemistry letters.

Comparative studies on the antirhinovirus activity and the mode of action of the rhinovirus capsid binding agents, chalcone amides.

H. Ishitsuka, N. Shimma, Y. Ninomiya, 1990, Antiviral research.

Synthesis and structure-activity relationships of a novel antifungal agent, azoxybacilin.

N. Shimma, I. Umeda, Y. Aoki, 1994, Chemical & pharmaceutical bulletin.

C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

M. Ohmori, N. Shimma, Takamitsu Kobayashi, 2012, Bioorganic & medicinal chemistry.

In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.

M. Page, M. Arisawa, Kazuko Kobayashi, 2010, International journal of antimicrobial agents.

Hispidospermidin, a Novel Phospholipase C Inhibitor Produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. Part 2. Isolation, Characterization and Structural Elucidation.

H. Seto, N. Shimma, T. Ohtsuka, 1994 .

[Discovery and development of novel anticancer drug capecitabine].

H. Ishitsuka, I. Horii, N. Shimma, 1999, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

H. Koyano, T. Ishikawa, N. Shimma, 2012, Bioorganic & medicinal chemistry.

Discovery and Development of Novel Anticancer Drug Capecitabine

H. Ishitsuka, I. Horii, N. Shimma, 2000 .