P. Edwards

发表

Discovery of a novel warhead against beta-secretase through fragment-based lead generation.

Rutger H A Folmer, Stefan Geschwindner, S. Geschwindner, 2007, Journal of medicinal chemistry.

Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.

Gianni Chessari, Christopher W Murray, Miles Congreve, 2007, Journal of medicinal chemistry.

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

N. Blomberg, A. Breeze, S. Geschwindner, 2007, Current topics in medicinal chemistry.

Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines*

B. Greenberg, Xiaodong Liu, C. Birr, 2002, The Journal of Biological Chemistry.

Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases.

C. W. Scott, P. Edwards, M. Sylvester, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and physical characterization of a P1 arginine combinatorial library, and its application to the determination of the substrate specificity of serine peptidases.

P. Edwards, R. Mauger, S. Furlong, 2002, Bioorganic & medicinal chemistry.

Application of gene therapy to acute inflammatory diseases.

L. Moldawer, R. Minter, E. Copeland, 1999, Shock.

Molecular and mechanistic validation of delayed healing rat wounds as a model for human chronic wounds

G. Schultz, B. Mast, P. Edwards, 1999, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon

J. Vauthey, L. Moldawer, S. Lowry, 1996, The Journal of experimental medicine.

Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon.

L. Moldawer, J. Frazier, C. Edwards, 1998, Journal of applied physiology.

Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase.

C. Bryant, J. Williams, P. Edwards, 1997, Journal of medicinal chemistry.

Design, Synthesis, and Kinetic Evaluation of a Unique Class of Elastase Inhibitors, the Peptidyl α-Ketobenzoxazoles, and the X- Ray Crystal Structure of the Covalent Complex Between Porcine Pancreatic Elastase and Ac-Ala-Pro-Val-2-Benzoxazole.

E. Meyer, P. Edwards, P. Tuthill, 1992 .

Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.

J. Williams, R. Krell, P. Bernstein, 1997, Journal of medicinal chemistry.

The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.

W. Rumsey, J. R. Damewood, D. Banville, 2000, Bioorganic & medicinal chemistry letters.

Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.

J. Vauthey, L. Moldawer, C. Edwards, 1997, Journal of immunology.

Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome.

M. Cuesta, L. Moldawer, H. Oldenburg, 1996, Blood.

C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl alpha-ketoheterocycles.

Clay W Scott, C. W. Scott, P. Edwards, 2000, Immunopharmacology.

Exogenously administered interleukin-10 decreases pulmonary neutrophil infiltration in a tumor necrosis factor-dependent murine model of acute visceral ischemia.

L. Moldawer, T. Huber, E. Copeland, 1997, Journal of vascular surgery.

Mechanism of slow-binding inhibition of human leukocyte elastase by trifluoromethyl ketones.

R. Stein, P. Edwards, D. A. Trainor, 1987, Biochemistry.

Design of orally active, non-peptidic inhibitors of human leukocyte elastase.

P. Bernstein, J. R. Damewood, P. Edwards, 1994, Journal of medicinal chemistry.

Synthetic Inhibitors of Elastase

P. Bernstein, P. Edwards, 1994, Medicinal research reviews.

Inhibitors of human leukocyte elastase.

J. Williams, P. Bernstein, P. Edwards, 1994, Progress in medicinal chemistry.

.alpha.-Amino carbanions. Preparation, metalation, and alkylation of enamidines. Synthesis of piperidine and pyrrolidine natural products and homologation of carbonyl compounds

A. Meyers, P. Edwards, G. E. Jagdmann, 1985 .

Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones.

P. Edwards, B Gomes, P D Edwards, 1996, Journal of medicinal chemistry.

Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl .alpha.-ketobenzoxazoles, and the x-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-benzoxazole

Edgar F. Meyer, J. Vijayalakshmi, E. Meyer, 1992 .

.alpha.-Amino carbanions via formamidines. Alkylation of pyrrolidines, piperidines, and related heterocycles

A. Meyers, P. Edwards, T. Bailey, 1984 .

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.

Gianni Chessari, Mark Sylvester, Rutger H A Folmer, 2007, Journal of medicinal chemistry.

Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 2. Effect of varying the heterocyclic ring on in vitro potency.

P. Edwards, M. Davis, D. Wolanin, 1995, Journal of medicinal chemistry.

Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles.

J. Williams, P. Edwards, P. Tuthill, 1995, Journal of medicinal chemistry.

A convenient synthesis of 1-azabicycloalkanes and their lactams via cuprates of formamidines

A. Meyers, P. Edwards, 1984 .

On the stereochemistry of the solvolytic c/d ring cleavage of the 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a] quinolizine system

S. Quarrie, P. Edwards, M. Calverley, 1981 .

A method for the stereoselective synthesis of peptidyl trifluoromethyl ketones

P. Edwards, 1992 .

A new synthesis of indolo[2,3-α]quinolizidine derivatives: a formal total synthesis of (±)-geissoschizine

P. Edwards, M. Calverley, B. J. Banks, 1981 .

Total synthesis of ionophores the monensin BC-rings via permanganate promoted stereospecific oxidative cyclization

D. Walba, P. Edwards, 1980 .

Inhibitors of human neutrophil elastase

P. Edwards, C. Veale, 1997 .

Computer-aided design of novel inhibitors of human leukocyte elastase

P. Bernstein, P. Warner, J. R. Damewood, 1997 .

Nitric oxide contributes to adriamycin's antitumor effect.

D. S. Lind, L. Moldawer, E. Copeland, 1997, The Journal of surgical research.

Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.

P. Bernstein, J. R. Damewood, P. Edwards, 1994, Journal of medicinal chemistry.

The influence of retinoic acid receptor (RAR) status of bladder tumours on the course of the disease.

D. Wallace, P. Edwards, A. D. De Bolla, 1985, British journal of urology.

Arginine-enhanced enteral nutrition augments the growth of a nitric oxide-producing tumor.

D. S. Lind, L. Moldawer, E. Copeland, 1997, JPEN. Journal of parenteral and enteral nutrition.

Tumor cell nitric oxide inhibits cell growth in vitro, but stimulates tumorigenesis and experimental lung metastasis in vivo.

D. S. Lind, L. Moldawer, J. Cendan, 1996, The Journal of surgical research.

Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase.

Clay W Scott, Xiao Hong Yu, P. Edwards, 2011, European journal of pharmacology.

Conversion of cystitis glandularis to adenocarcinoma.

P. Edwards, W. Jaeschke, P. D. Edwards, 1972, The Journal of urology.

Review Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis Inhibitors of human neutrophil elastase

P. Edwards, C. Veale, 1997 .

Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones.

J. Williams, P. Warner, P. Edwards, 1994, Journal of medicinal chemistry.