A. Hirsch

发表

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry.

Gerhard Klebe, Nedyalka Radeva, Constantinos Potamitis, 2014, Angewandte Chemie.

Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers

Anna K H Hirsch, Jean-Marie Lehn, J. Lehn, 2017, Accounts of chemical research.

Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors.

M. Mondal, A. Hirsch, A. Huizing, 2015, Journal of medicinal chemistry.

Lipid‐DNAs as Solubilizers of mTHPC

A. Herrmann, G. Wieland, H. Börner, 2017, Chemistry.

Fine-tuning Nanocarriers Specifically toward Cargo: A Competitive Study on Solubilizing Related Photosensitizers for Photodynamic Therapy.

H. Börner, Z. Kochovski, A. Hirsch, 2017, Bioconjugate chemistry.

Insight into the complete substrate-binding pocket of ThiT by chemical and genetic mutations.

S. Marrink, I. Faustino, D. Slotboom, 2017, MedChemComm.

Fragment‐Based Drug Design Facilitated by Protein‐Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

Asish Pal, M. Mondal, A. Hirsch, 2016, Chemistry.

Studying thiamine binding to ThiT using chemical and biochemical mutations

S. Marrink, I. Faustino, D. Slotboom, 2016 .

Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteria

D. Slotboom, A. Hirsch, R. Oudshoorn, 2016 .

Structure‐Based Design of Potent Small‐Molecule Binders to the S‐Component of the ECF Transporter for Thiamine

A. Guskov, D. Slotboom, Guus B. Erkens, 2015, Chembiochem : a European journal of chemical biology.

Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

G. Klebe, M. Mondal, Nedyalka Radeva, 2015, International journal of molecular sciences.

De novo fragment-based design of inhibitors of DXS guided by spin-diffusion-based NMR spectroscopy

C. Griesinger, M. Fischer, A. Hirsch, 2014 .

Total Synthesis of (−)‐Doliculide, Structure–Activity Relationship Studies and Its Binding to F‐Actin

H. Waldmann, Sayantani Roy, A. Minnaard, 2012, Chembiochem : a European journal of chemical biology.

Tunable energy and mass renormalization from homothetic Quantum dot arrays

A. Arnau, J. Ortega, A. Hirsch, 2019 .

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors

A. Abadi, Grigoris Zoidis, M. Hamed, 2022, Pharmaceuticals.

Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

B. Habenstein, I. J. van der Klei, M. Bramkamp, 2020, eLife.

Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

I. J. van der Klei, M. Bramkamp, A. Zielińska, 2019, bioRxiv.

Pentapeptide‐rich peptidoglycan at the Bacillus subtilis cell‐division site

J. Veening, Ka Beilharz, C. Mayer, 2017, Molecular microbiology.

Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

A. Hirsch, S. Adam, Rawia Hamid, 2022, bioRxiv.

Bicyclic enol cyclocarbamates inhibit penicillin-binding proteins.

J. Veening, M. Witte, Menno B. Tol, 2017, Organic & biomolecular chemistry.

Druggability of the enzymes of the non-mevalonate-pathway.

A. Hirsch, T. Masini, B. Kroezen, 2013, Drug discovery today.

Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment‐Based Drug Design Facilitated by Dynamic Combinatorial Chemistry

G. Klebe, S. Otto, M. Mondal, 2016, Angewandte Chemie.

Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection

R. Hartmann, R. Bals, C. Herr, 2020, Scientific Reports.

"Clicking" fragment leads to novel dual-binding cholinesterase inhibitors.

A. Zawadzka, A. Hirsch, Z. Czarnocki, 2021, Bioorganic & medicinal chemistry.

Surface state tunable energy and mass renormalization from homothetic quantum dot arrays.

A. Arnau, J. Ortega, A. Hirsch, 2019, Nanoscale.

Low-Dimensional Metal–Organic Coordination Structures on Graphene

R. Havenith, A. Hirsch, M. Enache, 2019, The journal of physical chemistry. C, Nanomaterials and interfaces.

Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape.

C. Lehr, B. Loretz, M. Koch, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds.

S. Ley, A. Hirsch, M. Gaunt, 2006, The Journal of organic chemistry.

Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar‐Based Molecules that Target Bacterial Glucosyltransferase

L. Dijkhuizen, V. R. Jumde, A. Hirsch, 2020, Chemmedchem.

Metal-ion-induced shape switching: Stereoselective formation of a dinuclear Hg(II) double helicate from a hydrazonobis(acylhydrazone) ligand

J. Lehn, Gaël Schaeffer, J. Harrowfield, 2012 .

Total synthesis, stereochemical elucidation and biological evaluation of Ac2SGL; a 1,3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis

L. Mori, G. Libero, G. Puzo, 2013 .

Biodynamers: self-organization-driven formation of doubly dynamic proteoids.

J. Lehn, A. Hirsch, E. Buhler, 2012, Journal of the American Chemical Society.

Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets.

Milon Mondal, Anna K H Hirsch, M. Mondal, 2015, Chemical Society reviews.

Proteoid Dynamers with Tunable Properties

J. Lehn, M. Stuart, A. Hirsch, 2016 .

Saccharide‐Containing Dynamic Proteoids

M. Witte, M. Stuart, A. Hirsch, 2017, Chemistry.

Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.

D. Hawksley, M. Fischer, F. Leeper, 2015, Organic & biomolecular chemistry.

Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S‐Component of the Energy‐Coupling Factor Transporter for Thiamine

I. Setyawati, D. Slotboom, A. Hirsch, 2017, ChemMedChem.

Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site

A. C. Terwisscha van Scheltinga, J. Hekelaar, M. Mondal, 2016, Journal of enzyme inhibition and medicinal chemistry.

Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier.

A. Abadi, R. Bartenschlager, Grigoris Zoidis, 2021, European journal of medicinal chemistry.

Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.

A. Hirsch, T. Masini, 2014, Journal of medicinal chemistry.

Unveiling Adatoms in On-Surface Reactions: Combining Scanning Probe Microscopy with van’t Hoff Plots

D. J. Mowbray, A. Hirsch, M. Stöhr, 2021, The journal of physical chemistry. C, Nanomaterials and interfaces.

Comparing the Self‐Assembly of Sexiphenyl‐Dicarbonitrile on Graphite and Graphene on Cu(111)

R. Havenith, A. Hirsch, M. Enache, 2019, Chemistry.

Fragment growing exploiting dynamic combinatorial chemistry of inhibitors of the aspartic protease endothiapepsin

Milon Mondal, Daphne E. Groothuis, M. Mondal, 2015 .

A natural-product switch for a dynamic protein interface.

C. Ottmann, R. Boelens, H. Wienk, 2014, Angewandte Chemie.

Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster

A. Hirsch, M. Nesterkina, S. Bilokon, 2023, Toxicology reports.

Theoretical and structural analysis of long C-C bonds in the adducts of polycyanoethylene and anthracene derivatives and their connection to the reversibility of Diels-Alder reactions.

J. Lehn, S. Ulrich, P. Reutenauer, 2014, Chemistry.

Phage Display on the Anti‐infective Target 1‐Deoxy‐d‐xylulose‐5‐phosphate Synthase Leads to an Acceptor–Substrate Competitive Peptidic Inhibitor

A. Herrmann, M. Fischer, A. Hirsch, 2017, Chembiochem : a European journal of chemical biology.

Exploiting specific interactions toward next-generation polymeric drug transporters.

S. Hackbarth, B. Röder, H. Börner, 2013, Journal of the American Chemical Society.

Concepts and Core Principles of Fragment-Based Drug Design

Anna K H Hirsch, Martin Empting, Philine Kirsch, 2019, Molecules.

Delivery system for budesonide based on lipid‐DNA

A. Hirsch, Yun Liu, H. Meurs, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Glucansucrase (mutant) enzymes from Lactobacillus reuteri 180 efficiently transglucosylate Stevia component rebaudioside A, resulting in a superior taste

L. Dijkhuizen, K. Dewettinck, D. Van de Walle, 2018, Scientific Reports.

DXS as a target for structure-based drug design.

C. Wrenger, M. Groves, A. Hirsch, 2017, Future medicinal chemistry.

Electronic Supplementary Information: Surface state tunable energy and mass renormalization from homothetic Quantum dot arrays

A. Arnau, J. Ortega, A. Hirsch, 2019 .

Comparing the Self‐Assembly of Sexiphenyl‐Dicarbonitrile on Graphite and Graphene on Cu(111)

Mihaela D. Enache, Jun Yu Li, R. Havenith, 2019, Chemistry.

Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols

B. Plietker, A. Hirsch, Y. Hamdaoui, 2022 .

Biodynamers: self-organization-driven formation of doubly dynamic proteoids.

J. Lehn, A. Hirsch, E. Buhler, 2012, Journal of the American Chemical Society.

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry.

G. Klebe, A. Park, C. Potamitis, 2014, Angewandte Chemie.

Fragment growing exploiting dynamic combinatorial chemistry of inhibitors of the aspartic protease endothiapepsin

Daphne E. Groothuis, M. Mondal, A. Hirsch, 2015 .

Dynamic Proteoids Generated From Dipeptide-Based Monomers.

M. Stuart, A. Hirsch, Yun Liu, 2018, Macromolecular rapid communications.