C. Handley

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Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH.

H. C. Robinson, C. Handley, M. T. Mok, 2001, Matrix biology : journal of the International Society for Matrix Biology.

Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.

A. J. Day, Gavin C. Jones, C. Handley, 2003, European journal of biochemistry.

Indomethacin Use for the Management of Patent Ductus Arteriosus in Preterms: A Web-Based Survey of Practice Attitudes Among Neonatal Fellowship Program Directors in the United States

C. Handley, O. Carter-Pokras, S. Amin, 2007, Pediatric Cardiology.

Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage.

A. Herington, C. Handley, M. Campbell, 1986, The Biochemical journal.

Modulation of aggrecan and link-protein synthesis in articular cartilage.

C. Handley, R. Devenish, A. J. Curtis, 1992, The Biochemical journal.

The MMP3 gene in musculoskeletal soft tissue injury risk profiling: A study in two independent sample groups

J. Cook, C. Handley, M. Collins, 2017, Journal of sports sciences.

Involvement of proteoglycans in tendinopathy.

J. Parkinson, J. Cook, C. Handley, 2011, Journal of musculoskeletal & neuronal interactions.

Changes in the composition of the extracellular matrix in patellar tendinopathy.

J. Parkinson, J. Feller, J. Cook, 2009, Matrix biology : journal of the International Society for Matrix Biology.

Change in proteoglycan metabolism is a characteristic of human patellar tendinopathy.

J. Parkinson, J. Feller, J. Cook, 2010, Arthritis and rheumatism.

Mechanism of catabolism of aggrecan by articular cartilage.

H. C. Robinson, C. Handley, M. T. Mok, 1992, Archives of biochemistry and biophysics.

Calcium pentosan polysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures.

S. Munteanu, C. Handley, M. Z. Ilic, 2000, Arthritis and rheumatism.

Expression and activity of ADAMTS-5 in synovium.

R. Maki, I. Holen, Changlu Liu, 2001, European journal of biochemistry.

Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures.

S. Munteanu, C. Handley, M. Z. Ilic, 2002, Matrix biology : journal of the International Society for Matrix Biology.

Permeability of composite chondrocyte-culture-millipore membranes to solutes of varying size and shape.

B. Preston, C. Handley, G. Cumming, 1979, The Biochemical journal.

Association of type XI collagen genes with chronic Achilles tendinopathy in independent populations from South Africa and Australia

J. Cook, J. Patricios, C. Handley, 2013, British Journal of Sports Medicine.

The synthesis of elastin, collagen, and glycosaminoglycans by high density primary cultures of neonatal rat aortic smooth muscle. An ultrastructural and biochemical study.

B. Oakes, L. Sandberg, C. Handley, 1982, European journal of cell biology.

The oxidant hypochlorite (OCl-), a product of the myeloperoxidase system, degrades articular cartilage proteoglycan aggregate.

M. Baker, C. Handley, D. A. Lowther, 1991, Free radical biology & medicine.

Transport of neutral amino acids by adult articular cartilage.

C. Handley, D. A. Lowther, S. Byers, 1983, Connective tissue research.

[4] Assay of proteoglycan degradation

C. Handley, D. Buttle, 1995 .

Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.

J. Cook, C. Handley, M. Collins, 2013, Journal of science and medicine in sport.

Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association study.

J. Cook, M. Schwellnus, C. Handley, 2010, Rheumatology.

Components of the transforming growth factor- b family and the pathogenesis of human Achilles tendon pathology—a genetic association study RHEUMATOLOGY

M. Schwellnus, C. Handley, M. Collins, 2010 .

Biosynthesis of proteoglycans by isolated rabbit glomeruli.

E. Glasgow, V. Hascall, J. Stow, 1983, Archives of biochemistry and biophysics.

Identification of distinct metabolic pools of aggrecan and their relationship to type VI collagen in the chondrons of mature bovine articular cartilage explants.

H. C. Robinson, C. Handley, M. Z. Ilic, 1998, Connective tissue research.

Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation.

A. Barrett, J. Saklatvala, C. Handley, 1993, Arthritis and rheumatism.

The effect of retinoic acid on proteoglycan biosynthesis in bovine articular cartilage cultures.

C. Handley, M. Campbell, 1987, Archives of biochemistry and biophysics.

Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon

C. Handley, M. Z. Ilic, T. Samiric, 2006, The FEBS journal.

Bovine joint capsule and fibroblasts derived from joint capsule express aggrecanase activity.

I. Holen, C. Handley, M. Z. Ilic, 2000, Matrix biology : journal of the International Society for Matrix Biology.

The effect of serum on biosynthesis of proteoglycans by bovine articular cartilage in culture.

H. C. Robinson, V. Hascall, C. Handley, 1983, Archives of biochemistry and biophysics.

Passive loss of proteoglycan from articular cartilage explants.

W. Comper, C. Handley, S. Bolis, 1989, Biochimica et biophysica acta.

An ultrastructural and biochemical study of high density primary cultures of embryonic chick chondrocytes.

B. Oakes, C. Handley, D. A. Lowther, 1977, Journal of embryology and experimental morphology.

Characterization of the collagen synthesized by cultured cartilage cells.

B. Oakes, J. Bateman, C. Handley, 1975, Biochimica et biophysica acta.

Extracellular matrix metabolism by chondrocytes. III. Modulation of proteoglycan synthesis by extracellular levels of proteoglycan in cartilage cells in culture.

C. Handley, D. A. Lowther, 1977, Biochimica et biophysica acta.

Cleavage of proteoglycan aggregate by leucocyte elastase.

H. C. Robinson, C. Handley, M. T. Mok, 1992, Archives of biochemistry and biophysics.

Distinguishing Aggrecan Loss from Aggrecan Proteolysis in ADAMTS-4 and ADAMTS-5 Single and Double Deficient Mice*

A. Fosang, C. Handley, M. Z. Ilic, 2007, Journal of Biological Chemistry.

Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage.

B. Martinac, C. Handley, M. Z. Ilic, 2003, Osteoarthritis and cartilage.

Characterization of extracellular matrix macromolecules from bovine synovial capsule

C. Handley, M. Campbell, F. Kleftogiannis, 1994, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Polymorphonuclear neutrophils release 35S-labelled proteoglycans into cartilage during frustrated phagocytosis.

H. C. Robinson, C. Handley, E. Gardiner, 1994, European journal of biochemistry.

Characterization of Aggrecan Retained and Lost from the Extracellular Matrix of Articular Cartilage

H. C. Robinson, C. Handley, M. Z. Ilic, 1998, The Journal of Biological Chemistry.

The effect of retinoic acid on proteoglycan turnover in bovine articular cartilage cultures.

C. Handley, M. Campbell, 1987, Archives of biochemistry and biophysics.

Turnover of proteoglycans in cultures of bovine articular cartilage.

V. Hascall, C. Handley, M. Campbell, 1984, Archives of biochemistry and biophysics.

Assay of proteoglycan degradation.

C. Handley, D. Buttle, 1995, Methods in enzymology.

Proteoglycans and catabolic products of proteoglycans present in ligament.

J. Dudhia, C. Handley, M. Z. Ilic, 2005, The Biochemical journal.

Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendon.

C. Handley, M. Z. Ilic, T. Samiric, 2004, Matrix biology : journal of the International Society for Matrix Biology.

Distribution of newly synthesized aggrecan in explant cultures of bovine cartilage treated with retinoic acid.

C. Handley, M. Z. Ilic, J. Ross, 2002, Matrix biology : journal of the International Society for Matrix Biology.

The structure and synthesis of proteoglycans of articular cartilage.

C. Handley, D. A. Lowther, D. McQuillan, 1985, Cell biology international reports.

Structure, metabolism, and tissue roles of chondroitin sulfate proteoglycans.

C. Handley, M. Z. Ilic, T. Samiric, 2006, Advances in pharmacology.

Catabolism of newly synthesized decorin by explant cultures of bovine ligament.

H. C. Robinson, C. Handley, M. Campbell, 2000, Matrix biology : journal of the International Society for Matrix Biology.

Immunochemical studies of opsonic epitopes of the lipopolysaccharide of Leptospira interrogans serovar hardjo.

B. Adler, C. Handley, S. Faine, 1994, FEMS immunology and medical microbiology.

Oxygen free-radicals mediate an inhibition of proteoglycan synthesis in cultured articular cartilage.

C. Handley, D. A. Lowther, E. J. Bates, 1984, Annals of the rheumatic diseases.

Effects of free and bound insulin‐like growth factors on proteoglycan metabolism in articular cartilage explants

H. Cornell, A. Herington, C. Handley, 1992, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Rabbit Polymorphonuclear Neutrophils Form 35S-Labeled S-Sulfo-calgranulin C When Incubated with Inorganic [35S]Sulfate*

H. C. Robinson, C. Handley, R. Devenish, 1996, The Journal of Biological Chemistry.

Presence of antibodies to native G1 domain of aggrecan core protein in synovial fluids from patients with various joint diseases.

M. Rowley, C. Handley, M. Z. Ilic, 1996, Arthritis and rheumatism.

The extracellular processing and catabolism of hyaluronan in cultured adult articular cartilage explants.

H. C. Robinson, B. Preston, C. Handley, 1992, Archives of biochemistry and biophysics.

Increased versican content is associated with tendinosis pathology and microvascular hyperplasia in the patellar tendon of athletes with jumper ’ s knee

R. Bahr, J. Parkinson, D. Hart, 2009 .

Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee

R. Bahr, J. Parkinson, D. Hart, 2007, Scandinavian journal of medicine & science in sports.

Biosynthesis and turnover of proteoglycans in organ culture of bovine articular cartilage.

V. Hascall, C. Handley, T. I. Morales, 1983, The Journal of rheumatology. Supplement.

Characterization of the proteoglycans synthesized by rabbit testis in response to infection by Treponema pallidum.

R. Strugnell, C. Handley, L. Drummond, 1986, The American journal of pathology.

GENE EXPRESSION OF MATRIX-DEGRADING ENZYMES IN PATELLAR TENDINOPATHY

J. Parkinson, C. Handley, T. Samiric, 2013, British Journal of Sports Medicine.

A. Fosang, C. Handley, G. Thorburn, 1984, Biology of reproduction.

Molecular size distribution of proteoglycan subunits and glycosaminoglycans synthesized by chondrocytes under conditions of reduced proteoglycan synthesis.

H. C. Robinson, C. Handley, G. Speight, 1980, Biochimica et biophysica acta.

Effect of insulin-like growth factor-I on the synthesis and distribution of link protein and hyaluronan in explant cultures of articular cartilage.

H. C. Robinson, C. Handley, C. Ng, 1992, Biochimica et biophysica acta.

Metabolic processing of newly synthesized link protein in bovine articular cartilage explant cultures.

H. C. Robinson, C. Handley, M. Z. Ilic, 1999, Matrix biology : journal of the International Society for Matrix Biology.

Changes in proteoglycan biosynthesis following leukocyte elastase treatment of bovine articular cartilage in culture.

C. Handley, D. A. Lowther, J. Bartholomew, 1984, Arthritis and rheumatism.

Extracellular matrix metabolism by chondrocytes. 7. Evidence that L-glutamine is an essential amino acid for chondrocytes and other connective tissue cells.

C. Handley, G. Speight, D. A. Lowther, 1980, Biochimica et biophysica acta.

Extracellular matrix metabolism by chondrocytes. 4. Role of glutamine in glycosaminoglycan synthesis in vitro by chondrocytes.

C. Handley, G. Speight, D. A. Lowther, 1978, Biochimica et biophysica acta.

Carrageenin‐induced arthritis

C. Handley, D. Carmichael, D. A. Lowther, 1977 .

Carrageenin-induced arthritis. IV. Rate changes in cartilage matrix proteoglycan synthesis.

C. Handley, D. Carmichael, D. A. Lowther, 1977, Arthritis and rheumatism.

Polyanions in syphilis: evidence that glycoproteins and macromolecules resembling glycosaminoglycans are synthesised by host tissues in response to infection with Treponema pallidum.

R. Strugnell, C. Handley, D. A. Lowther, 1984, The British journal of venereal diseases.

aresynthesised byhosttissues inresponseto infection withTreponema pallidum

R. Strugnell, C. Handley, D. A. Lowther, 1984 .

The biosynthesis in vitro of keratan sulphate in bovine cornea.

C. Handley, C. Phelps, 1972, The Biochemical journal.

ELN and FBN2 Gene Variants as Risk Factors for Two Sports-related Musculoskeletal Injuries

J. Cook, C. Handley, M. Collins, 2014, International Journal of Sports Medicine.

Effects of glucosamine on proteoglycan loss by tendon, ligament and joint capsule explant cultures.

B. Martinac, C. Handley, M. Z. Ilic, 2008, Osteoarthritis and cartilage.

Biochemical changes in cervical mucus‐factor infertility

A. Trounson, C. Handley, J. McBain, 1985 .

Inhibition of proteoglycan biosynthesis by hyaluronic acid in chondrocytes in cell culture.

C. Handley, D. A. Lowther, 1976, Biochimica et biophysica acta.

AN OVARIAN TUMOUR SPECIFIC MUCIN ANTIGEN—IMMUNOHISTOLOGICAL AND BIOCHEMICAL STUDIES

C. Handley, Jeng-Shin Ma, W. G. Boer, 1983, Pathology.

Characteristics of the core protein of the aggregating proteoglycan from the Swarm rat chondrosarcoma

V. Hascall, B. Caterson, C. Handley, 1984, Journal of cellular biochemistry.

Characterization of a large chondroitin sulfate proteoglycan present in bovine collateral ligament.

G. Chow, C. Handley, M. Campbell, 1996, Archives of biochemistry and biophysics.

Extracellular matrix metabolism by chondrocytes. VI. Concomitant depression by exogenous levels of proteoglycan of collagen and proteoglycan synthesis by chondrocytes.

P. Brooks, C. Handley, D. A. Lowther, 1978, Biochimica et biophysica acta.

Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations

J. Cook, L. van der Merwe, C. Handley, 2014, Journal of sports sciences.

Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations

J. Cook, M. Schwellnus, L. van der Merwe, 2008, British Journal of Sports Medicine.

Connective tissue remodelling in the ovine cervix during pregnancy and at term.

A. Fosang, C. Handley, 1988, Connective tissue research.

The aggregation of human platelets by ascitic fluid: A possible mechanism for disseminated intravascular coagulation complicating LeVeen shunts

C. Handley, J. Koutts, F. Dudley, 1981, American journal of hematology.

with Achilles tendinopathy in two populations gene are associated COL5A1 Variants within the

J. Cook, M. Schwellnus, C. Handley, 2009 .

Proceedings: The ultrastructural morphology and biochemistry of chick embryo chondrocytes in culture.

B. Oakes, C. Handley, 1974, Journal of anatomy.

A pathway-based approach investigating the genes encoding interleukin-1β, interleukin-6 and the interleukin-1 receptor antagonist provides new insight into the genetic susceptibility of Achilles tendinopathy

J. Cook, M. Schwellnus, L. van der Merwe, 2011, British Journal of Sports Medicine.

Intrasynovial levels of sulphated glycosaminoglycans and autoantibodies to type II collagen in rheumatoid arthritis: a correlative analysis

M. Rowley, C. Handley, C. Karopoulos, 2004, Rheumatology International.

The biosynthesis in vitro of chondroitin sulphate in neonatal rat epiphysial cartilage.

C. Handley, C. Phelps, 1972, The Biochemical journal.

Extracellular matrix metabolism by chondrocytes. 5. The proteoglycans and glycosaminoglycans synthesized by chondrocytes in high density cultures.

C. Handley, D. A. Lowther, 1979, Biochimica et biophysica acta.

Effect of exogenous hyaluronan and hyaluronan oligosaccharides on hyaluronan and aggrecan synthesis and catabolism in adult articular cartilage explants.

H. C. Robinson, B. Preston, C. Handley, 1995, Archives of Biochemistry and Biophysics.

Synthesis of hyaluronate in cultured bovine articular cartilage.

H. C. Robinson, R. Mason, C. Handley, 1989, The Biochemical journal.

"Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay.

C. Handley, M. Z. Ilic, D. Buttle, 1997, Molecular pathology : MP.

In vitro response of chondrocytes to mechanical loading. The effect of short term mechanical tension.

B. Oakes, C. Handley, B W Oakes, 1984, Connective tissue research.

Cell transport in model extracellular matrices.

G. Harper, L. Pratt, W. Comper, 1987, Archives of biochemistry and biophysics.

Antibody reactivity to mycobacterial 65 kDa heat shock protein: relevance to autoimmunity.

M. Rowley, R. Strugnell, C. Handley, 1995, Journal of autoimmunity.

The effects of trypsin treatment on proteoglycan biosynthesis by bovine articular cartilage.

C. Handley, D. A. Lowther, J. Bartholomew, 1985, Biochemical Journal.

Turnover of proteoglycans in articular-cartilage cultures. Characterization of proteoglycans released into the medium.

C. Handley, M. Campbell, S. D’Souza, 1989, The Biochemical journal.

Characterization and synthesis of macromolecules by adult collateral ligament.

B. Oakes, C. Handley, C. Ng, 1990, Biochimica et biophysica acta.

Investigation of variants within the COL27A1 and TNC genes and Achilles tendinopathy in two populations

J. Cook, L. van der Merwe, C. Handley, 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Large aggregating and small leucine-rich proteoglycans are degraded by different pathways and at different rates in tendon.

C. Handley, M. Z. Ilic, T. Samiric, 2004, European journal of biochemistry.

Kinetics of release of aggrecan from explant cultures of bovine cartilage from different sources and from animals of different ages.

C. Handley, M. Z. Ilic, S. Haynes, 1995, Acta orthopaedica Scandinavica. Supplementum.

Effectiveness of intra-articular hyaluronan (Synvisc, hylan G-F 20) for the treatment of first metatarsophalangeal joint osteoarthritis: a randomised placebo-controlled trial

H. Menz, K. Landorf, S. Munteanu, 2011, Annals of the rheumatic diseases.

Efficacy of intra-articular hyaluronan (Synvisc®) for the treatment of osteoarthritis affecting the first metatarsophalangeal joint of the foot (hallux limitus): study protocol for a randomised placebo controlled trial

H. Menz, K. Landorf, S. Munteanu, 2009, Journal of foot and ankle research.

Short- and long-term exposure of articular cartilage to curcumin or quercetin inhibits aggrecan loss.

C. Handley, M. Z. Ilic, T. Samiric, 2012, The Journal of nutritional biochemistry.

Training bei Tendinopathien – Sehnenstress

S. Woo, R. Bahr, P. Fisher, 2017, Sportverletzung · Sportschaden.

The apoptosis pathway and the genetic predisposition to Achilles tendinopathy

J. Cook, L. van der Merwe, C. Handley, 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Coincubation of bovine synovial or capsular tissue with cartilage generates a soluble "Aggrecanase" activity.

C. Handley, M. Z. Ilic, D. Buttle, 1999, Biochemical and biophysical research communications.

Carrageenin-induced arthritis. III. Proteolytic enzymes present in rabbit knee joints after a single intraarticular injection of carrageenin.

C. Handley, D. A. Lowther, G. Gillard, 1976, Arthritis and rheumatism.

Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid.

C. Hughes, C. Handley, M. T. Mok, 1995, Archives of biochemistry and biophysics.

Size of aggrecan core protein synthesized bychondrocytes grown in monolayers and in collagen gels with time in culture

B. Oakes, C. Handley, M. V. Damme, 1998 .

Extracellular matrix proteins interact with cell‐signaling pathways in modifying risk of achilles tendinopathy

J. Cook, L. van der Merwe, C. Handley, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Treponema pallidum does not synthesise in vitro a capsule containing glycosaminoglycans or proteoglycans.

R. Strugnell, C. Handley, D. A. Lowther, 1984, The British journal of venereal diseases.

Effect of dibutyryl cyclic AMP on the sulphation of proteoglycans by chondrocytes.

C. Handley, G. Speight, D. A. Lowther, 1981, Biochimica et biophysica acta.

The relation of RNA synthesis to chondroitin sulphate biosynthesis in cultured bovine cartilage.

C. Handley, K. Ng, D. McQuillan, 1984, The Biochemical journal.

Experimental syphilitic orchitis. Relationship between Treponema pallidum infection and testis synthesis of proteoglycans.

R. Strugnell, C. Handley, S. Faine, 1988, The American journal of pathology.

Carrageenin-induced arthritis. VI. Alterations in amino acid transport by articular cartilage in acute inflammatory arthritis.

C. Handley, A. Sriratana, D. A. Lowther, 1985, Annals of the rheumatic diseases.

[21] Catabolism and turnover of proteoglycans

C. Handley, M. Campbell, 1987 .

The concentrations of sugar nucleotides in bovine corneal epithelium and endothelium.

C. Handley, C. Phelps, 1972, The Biochemical journal.

Treponema pallidum doesnotsynthesise invitro a capsule containing glycosaminoglycans

R. Strugnell, C. Handley, D. A. Lowther, 2017 .

The MMP3 gene in musculoskeletal soft tissue injury risk profiling: A study in two independent sample groups

C. Handley, M. Collins, A. September, 2017, Journal of sports sciences.

Change in proteoglycan metabolism is a characteristic of human patellar tendinopathy.

J. Parkinson, J. Feller, J. Cook, 2010, Arthritis and rheumatism.