X. Qiu

发表

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Li Xing, Guoyun Bai, Atli Thorarensen, 2016, Scientific Reports.

Crystal structure and substrate specificity of the β‐ketoacyl‐acyl carrier protein synthase III (FabH) from Staphylococcus aureus

C. Janson, S. Khandekar, M. Grooms, 2005, Protein science : a publication of the Protein Society.

Structural and biophysical insight into cholesteryl ester-transfer protein.

X. Qiu, Justin Hall, 2011, Biochemical Society transactions.

Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents

Martha S. Head, Xiayang Qiu, Cheryl A. Janson, 2002, Antimicrobial Agents and Chemotherapy.

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

R. Kurumbail, M. Harris, Hong Wang, 2014, Structure.

Insights into Mechanism of Glucokinase Activation

M. Ammirati, J. Pfefferkorn, S. Greasley, 2012, The Journal of Biological Chemistry.

Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.

Xiayang Qiu, David J Payne, M. Head, 2003, Journal of medicinal chemistry.

Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.

R. Kurumbail, M. Harris, K. Geoghegan, 2010, Protein expression and purification.

1 SRT 1720 , SRT 2183 , SRT 1460 , AND RESVERATROL ARE NOT DIRECT ACTIVATORS OF SIRT 1

B. Stockman, A. Varghese, J. Withka, 2010 .

Crystal structure and substrate specificity of the β‐ketoacyl‐acyl carrier protein synthase III (FabH) from Staphylococcus aureus

C. Janson, S. Khandekar, M. Grooms, 2005, Protein science : a publication of the Protein Society.

Cholesteryl Ester Transfer Protein Variants Have Differential Stability but Uniform Inhibition by Torcetrapib*

Johnf . Thompson, P. Milos, A. Lanzetti, 2005, Journal of Biological Chemistry.

A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity

X. Qiu, Litao Sun, Weiwei Ma, 2019, Nature.

Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins

M. Ammirati, K. Fennell, M. Yeager, 2020, Nature Communications.

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

M. Ammirati, J. Treadway, S. Liras, 2011 .

Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex.

C. Debouck, A. Dilella, S. Abdel-Meguid, 1997, Biochemistry.

Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia risk

T. Rolph, J. Pfefferkorn, K. Borzilleri, 2014 .

Faculty Opinions recommendation of Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2.

X. Qiu, Litao Sun, 2020 .

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

Graham M. West, J. Culp, E. Carpenter, 2019, eLife.

Discovery and structural characterization of an allosteric inhibitor of bacterial cis‐prenyltransferase

K. Fennell, D. Danley, B. Chrunyk, 2015, Protein Science.

Structural basis for the transport mechanism of the human glutamine transporter SLC1A5 (ASCT2)

Graham M. West, J. Culp, E. Carpenter, 2019, bioRxiv.

Faculty Opinions recommendation of GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.

Xiayang Qiu, X. Qiu, 2007 .

Crystal structure of Staphylococcus aureus tyrosyl‐tRNA synthetase in complex with a class of potent and specific inhibitors

Xiayang Qiu, Paul Carter, Judith M. LaLonde, 2001, Protein science : a publication of the Protein Society.

Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.

C. Janson, A. Fosberry, D. D. Jaworski, 2001, Bioorganic & medicinal chemistry letters.

Molecular basis for triclosan activity involves a flipping loop in the active site

S. Abdel-Meguid, C. Janson, D. Payne, 2008, Protein science : a publication of the Protein Society.

Refined structures of beta-ketoacyl-acyl carrier protein synthase III.

M. Head, C. Janson, Ward W. Smith, 2001, Journal of molecular biology.

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).

C. Janson, A. Fosberry, Ward W. Smith, 2001, Bioorganic & medicinal chemistry letters.

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).

Xiayang Qiu, David J Payne, M. Head, 2002, Journal of medicinal chemistry.

Unique fold and active site in cytomegalovirus protease

J. Culp, A. Dilella, S. Abdel-Meguid, 1996, Nature.

cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.

M. Ammirati, D. Danley, S. Wright, 2006, Journal of medicinal chemistry.

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules

Ing-Kae Wang, Xiayang Qiu, Dennis E Danley, 2007, Nature Structural &Molecular Biology.

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies

M. Ehlers, D. Krainc, P. Saftig, 2017, Nature Communications.

(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.

M. Ammirati, D. Danley, R. McPherson, 2009, Bioorganic & Medicinal Chemistry Letters.

Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion

P. Dormitzer, Xinzhen Yang, Seungil Han, 2021, Science Advances.

Delineating the role of cooperativity in the design of potent PROTACs for BTK

Graham M. West, James Smith, V. Shanmugasundaram, 2018, Proceedings of the National Academy of Sciences.

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

Hualiang Jiang, Xiayang Qiu, Mingzhu Wang, 2015, Genes & development.

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦

Venkataraman Thanabal, Jessica Ward, Xiayang Qiu, 2010, The Journal of Biological Chemistry.

Crystal structure of varicella-zoster virus protease.

J. Culp, C. Debouck, S. Abdel-Meguid, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The Human Herpes-Virus Proteases

S. Abdel-Meguid, C. Dabrowski, X. Qiu, 2000 .

Human Herpesvirus Proteases

S. Abdel-Meguid, X. Qiu, 1999 .

Crystal Structure of the Herpes Simplex Virus 1 DNA Polymerase*

Eric T Baldwin, Xiayang Qiu, E. Baldwin, 2006, Journal of Biological Chemistry.

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

Xiayang Qiu, Dennis E Danley, S. Shenolikar, 2007, Nature Structural &Molecular Biology.

HDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation

D. Johns, K. Rye, Matthew J. Rames, 2015, Scientific Reports.

A model for the mechanism of human topoisomerase I.

W G Hol, J. Champoux, W. Hol, 1998, Science.

First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling.

Xiayang Qiu, M. Head, C. Janson, 2003, Journal of medicinal chemistry.

Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis.

S. Abdel-Meguid, C. Janson, C. Silverman, 1999, The Journal of biological chemistry.

Crystal Structure of β-Ketoacyl-Acyl Carrier Protein Synthase III

Xiayang Qiu, Cheryl A. Janson, S. Abdel-Meguid, 1999, The Journal of Biological Chemistry.

Crystal Structures of Cholesteryl Ester Transfer Protein in Complex with Inhibitors

M. Griffor, Shenping Liu, X. Qiu, 2012, The Journal of Biological Chemistry.

Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein.

R. Krauss, K. Weisgraber, H. Pownall, 2012, Nature chemical biology.

Crystallization of Escherichia coli beta-ketoacyl-ACP synthase III and the use of a dry flash-cooling technique for data collection.

C. Janson, J. Lonsdale, X. Qiu, 2000, Acta crystallographica. Section D, Biological crystallography.

Expression, Purification, and Crystallization of the Escherichia coli Selenomethionyl β-Ketoacyl–Acyl Carrier Protein Synthase III

M. Doyle, J. Kane, D. Mcnulty, 2000 .

Cooperative structural dynamics and a novel fidelity mechanism in histidyl-tRNA synthetases.

S. Abdel-Meguid, C. Janson, X. Qiu, 1999, Biochemistry.

Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins

M. Ammirati, K. Fennell, M. Yeager, 2020, Nature Communications.

Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2).

M. Carty, G. Karam, W. Soeller, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal structure of human osteoclast cathepsin K complex with E-64

Xiayang Qiu, Cheryl A. Janson, Baoguang Zhao, 1997, Nature Structural Biology.

Structure of apo acyl carrier protein and a proposal to engineer protein crystallization through metal ions.

Xiayang Qiu, C. Janson, X. Qiu, 2004, Acta crystallographica. Section D, Biological crystallography.

Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection[S]

G. Karam, I. Wang, J. Boyd, 2010, Journal of Lipid Research.

Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide

G. Woodnutt, P. Sahasrabudhe, A. Thorarensen, 2016, Scientific Reports.

Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine

M. Ammirati, P. Dormitzer, K. Swanson, 2023, Science Translational Medicine.

High-resolution structure of the diphtheria toxin repressor complexed with cobalt and manganese reveals an SH3-like third domain and suggests a possible role of phosphate as co-corepressor.

W G Hol, W. Hol, E. Pohl, 1996, Biochemistry.

Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors.

C. Verlinde, W. Hol, M. Schmitt, 1995, Structure.

Comparison of high‐resolution structures of the diphtheria toxin repressor in complex with cobalt and zinc at the cation‐anion binding site

E. Pohl, R. Holmes, W. Hol, 1997, Protein science : a publication of the Protein Society.

Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange

Graham M. West, L. Byrnes, X. Qiu, 2018, Scientific Reports.

Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase

A. Aulabaugh, Zhao‐Kui Wan, Shenping Liu, 2012, The Journal of Biological Chemistry.

Faculty Opinions recommendation of Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.

X. Qiu, Y. Che, 2015 .

A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity.

K. Geoghegan, A. Aulabaugh, R. G. Silva, 2014, Analytical biochemistry.

Faculty Opinions recommendation of The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.

X. Qiu, Y. Che, 2017 .

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦

R. Garofalo, B. Stockman, A. Varghese, 2010, The Journal of Biological Chemistry.

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

R. Kurumbail, M. Harris, Hong Wang, 2014, Structure.

Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.

C. Janson, A. Pope, A. Saldanha, 1999, Bioorganic & medicinal chemistry letters.

Faculty Opinions recommendation of Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field.

Xiayang Qiu, Ye Che, X. Qiu, 2015 .

(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.

M. Ammirati, D. Danley, R. McPherson, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors.

M. Ammirati, R. McPherson, X. Qiu, 2007, Bioorganic & medicinal chemistry letters.