Benny J. Evison

发表

Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication*

R. Heath, H. Hashimoto, A. Inoue, 2012, The Journal of Biological Chemistry.

Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.

A. Inoue, C. Punchihewa, Benny J. Evison, 2013, Bioorganic & medicinal chemistry.

In vitro transcription assay for resolution of drug-DNA interactions at defined DNA sequences.

S. Cutts, D. Phillips, Benny J. Evison, 2010, Methods in molecular biology.

Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features.

J. Collins, S. Cutts, B. Sleebs, 2019, Bioorganic & medicinal chemistry.

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance.

R. Heath, A. Inoue, Benny J. Evison, 2018, Bioorganic & medicinal chemistry.

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.

R. Heath, H. Hashimoto, A. Inoue, 2016, Bioorganic & medicinal chemistry.

A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.

A. Inoue, Benny J. Evison, N. Fujii, 2015, Bioorganic & medicinal chemistry.

Formaldehyde-Activated Pixantrone Is a Monofunctional DNA Alkylator That Binds Selectively to CpG and CpA Doublets

G. Pezzoni, S. Cutts, D. Phillips, 2008, Molecular Pharmacology.

Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent

S. Cutts, D. Phillips, Benny J. Evison, 2007, Nucleic acids research.

A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.

Sanjay Kumar, H. Treutlein, A. Rathi, 2020, Bioorganic & medicinal chemistry.

An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells

A. Nudelman, S. Cutts, A. Rephaeli, 2022, Cancer Chemotherapy and Pharmacology.

DNA binding by pixantrone.

J. Collins, S. Cutts, D. Phillips, 2010, Organic & biomolecular chemistry.

Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [14C]-doxorubicin [Corrigendum]

P. Pigram, G. Pietersz, S. Cutts, 2016, Nanotechnology, science and applications.

P. Pigram, M. J. Masarudin, S. Cutts, 2015, Nanotechnology, science and applications.

Mitoxantrone, More than Just Another Topoisomerase II Poison

S. Cutts, B. Sleebs, D. Phillips, 2016, Medicinal research reviews.

DNA binding of the anti-cancer platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+

J. Collins, D. Phillips, N. Wheate, 2003 .

A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA).

R. Heath, Benny J. Evison, Youming Shao, 2014, Bioorganic & medicinal chemistry.

CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity

G. Pezzoni, S. Cutts, D. Phillips, 2009, Nucleic acids research.

M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe.

S. Cutts, R. Forrest, B. Sleebs, 2011, Biochemical pharmacology.

A Molecular Understanding of Mitoxantrone-DNA Adduct Formation

S. Cutts, D. Phillips, Benny J. Evison, 2004, Journal of Biological Chemistry.

The hydroxyl epimer of doxorubicin controls the rate of formation of cytotoxic anthracycline-DNA adducts

A. Nudelman, S. Cutts, A. Rephaeli, 2013, Cancer Chemotherapy and Pharmacology.

Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide.

R. Brownlee, S. Cutts, D. Phillips, 2014, Bioorganic & medicinal chemistry letters.

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin*

R. Heath, C. Canman, H. Hashimoto, 2014, The Journal of Biological Chemistry.

Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.

A. Inoue, Benny J. Evison, N. Fujii, 2018, Journal of molecular biology.

A clickable psoralen to directly quantify DNA interstrand crosslinking and repair.

Benny J. Evison, N. Fujii, Marcelo L. Actis, 2016, Bioorganic & medicinal chemistry.

A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.

A. Inoue, Benny J. Evison, N. Fujii, 2015, Bioorganic & medicinal chemistry.

New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation.

J. Collins, A. Nudelman, S. Cutts, 2010, Journal of medicinal chemistry.

P. Pigram, M. J. Masarudin, G. Pietersz, 2016, Nanotechnology, science and applications.

Nanotechnology, Science and Applications Dovepress

P. Pigram, S. Cutts, Benny J. Evison, 2022 .