N. Fujii

发表

Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication*

R. Heath, H. Hashimoto, A. Inoue, 2012, The Journal of Biological Chemistry.

Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.

A. Inoue, C. Punchihewa, Benny J. Evison, 2013, Bioorganic & medicinal chemistry.

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance.

R. Heath, A. Inoue, Benny J. Evison, 2018, Bioorganic & medicinal chemistry.

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.

R. Heath, H. Hashimoto, A. Inoue, 2016, Bioorganic & medicinal chemistry.

A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.

A. Inoue, Benny J. Evison, N. Fujii, 2015, Bioorganic & medicinal chemistry.

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.

Ju-Seog Lee, J. Ntambi, L. Mishra, 2017, Gastroenterology.

Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas.

N. Fujii, A. Naren, Weiqiang Zhang, 2012, Future medicinal chemistry.

A novel protein crosslinking reagent for the determination of moderate resolution protein structures by mass spectrometry (MS3-D).

R. Guy, J. Schoeniger, R. Jacobsen, 2004, Bioorganic & medicinal chemistry letters.

Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.

N. Mahindroo, H. Kimura, M. Connelly, 2009, Journal of medicinal chemistry.

Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains.

D. Bashford, N. Mahindroo, N. Fujii, 2008, Bioorganic & medicinal chemistry letters.

Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents

N. Mahindroo, C. Punchihewa, N. Fujii, 2009 .

Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway.

N. Mahindroo, B. Yan, M. Connelly, 2010, Bioorganic & medicinal chemistry.

Sequence requirement and subtype specificity in the high‐affinity interaction between human frizzled and dishevelled proteins

C. Punchihewa, R. Cassell, Patrick Rodrigues, 2009, Protein science : a publication of the Protein Society.

Partial acetylation of lysine residues improves intraprotein cross-linking.

Malin M. Young, I. Kuntz, B. Gibson, 2008, Analytical chemistry.

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

J. Gut, P. Rosenthal, R. Guy, 2005, Bioorganic & medicinal chemistry letters.

A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA crosslink, enhances DNA double-strand break, and sensitizes cancer cells to cisplatin

C. Canman, A. Inoue, A. Hishiki, 2014 .

Hedgehog-Gli signaling pathway inhibitors as anticancer agents.

N. Mahindroo, C. Punchihewa, N. Fujii, 2009, Journal of medicinal chemistry.

Synthesis of (+)-α-curcumene, (+)-curcumone, and (−)-methyl citronellate starting from optically pure 5-trimethylsilyl-2-cyclohexenone

Kunihisa Shima, N. Fujii, H. Takei, 1988 .

Diastereoselective 1,4-addition of various nucleophiles to 5-trimethylsilyl-2-cyclohexenone: synthesis of (+)-ramulosin

N. Fujii, H. Takei, M. Asaoka, 1990 .

Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures

H. Mo, R. Peterson, V. Davisson, 2022, Chemical research in toxicology.

Efficient formation of 4,6-disubstituted pyrrolo[2,3-d]pyrimidines: a novel route to TWS119, a glycogen synthase kinase-3β inhibitor

N. Fujii, Anand Mayasundari, 2010 .

An Anti-Wnt-2 Monoclonal Antibody Induces Apoptosis in Malignant Melanoma Cells and Inhibits Tumor Growth

K. Uematsu, F. McCormick, J. Mazières, 2004, Cancer Research.

Potential Strategies to Target Protein-Protein Interactions in the DNA Damage Response and Repair Pathways.

N. Fujii, 2017, Journal of medicinal chemistry.

A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA).

R. Heath, Benny J. Evison, Youming Shao, 2014, Bioorganic & medicinal chemistry.

A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription.

M. Connelly, C. Punchihewa, N. Fujii, 2011, Biopolymers.

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

K. Uematsu, R. Guy, G. Neale, 2007, Cancer research.

The hydrophobic amino acid cluster at the cytoplasmic end of transmembrane helix III modulates the coupling of the ß1-adrenergic receptor to Gs

S. Bahouth, L. Gardner, N. Fujii, 2013, Journal of receptor and signal transduction research.

Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach.

B. Yan, C. Punchihewa, A. Lemoff, 2011, The Biochemical journal.

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

J. Peters, H. Stark, P. Dube, 2015, Proceedings of the National Academy of Sciences.

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Steven M. Lewis, B. Kuhlman, B. Schulman, 2013, eLife.

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin*

R. Heath, C. Canman, H. Hashimoto, 2014, The Journal of Biological Chemistry.

Targeting Gli Transcription Activation by Small Molecule Suppresses Tumor Growth

Changli Wang, Hai-Meng Zhou, D. Jablons, 2013, Oncogene.

Capturing the Direct Binding of CFTR Correctors to CFTR by Using Click Chemistry

Chandrima Sinha, Kavisha Arora, Anjaparavanda P. Naren, 2015, Chembiochem : a European journal of chemical biology.

A selective irreversible inhibitor targeting a PDZ protein interaction domain.

Irwin D Kuntz, Jose J. Haresco, R Kiplin Guy, 2003, Journal of the American Chemical Society.

Role of electrostatic interactions in PDZ domain ligand recognition.

W. Lim, R. Guy, N. Fujii, 2003, Biochemistry.

Synthesis of (R)-(−)-O-methyljoubertiamine

N. Fujii, H. Takei, M. Asaoka, 1988 .

Investigation of the PDZ domain ligand binding site using chemically modified peptides.

R. Guy, N. Fujii, Kathleen A. P. Novak, 2002, Bioorganic & medicinal chemistry letters.

Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.

A. Inoue, Benny J. Evison, N. Fujii, 2018, Journal of molecular biology.

A clickable psoralen to directly quantify DNA interstrand crosslinking and repair.

Benny J. Evison, N. Fujii, Marcelo L. Actis, 2016, Bioorganic & medicinal chemistry.

Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.

C. Punchihewa, N. Fujii, Neeraj Mahindroo, 2008, Bioorganic & medicinal chemistry letters.

Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.

Irwin D Kuntz, Jose J. Haresco, R Kiplin Guy, 2007, Bioorganic & medicinal chemistry letters.

Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor–mediated transcription

L. You, D. Jablons, C. Punchihewa, 2008, Molecular Cancer Therapeutics.

Sequence requirement and subtype specificity in the high‐affinity interaction between human frizzled and dishevelled proteins

C. Punchihewa, R. Cassell, Patrick Rodrigues, 2009, Protein science : a publication of the Protein Society.

A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.

A. Inoue, Benny J. Evison, N. Fujii, 2015, Bioorganic & medicinal chemistry.

Discovery of diphenyloxazole and Ndelta-Z-ornithine derivatives as highly potent and selective human prostaglandin EP(4) receptor antagonists.

A. Tanaka, N. Fujii, Y. Tenda, 2005, Journal of medicinal chemistry.

A phenotypic screen with Trypanosoma brucei for discovering small molecules that target the SLiM-binding pocket of proliferating cell nuclear antigen orthologs.

N. Fujii, Marisa Actis, Zachary B Mackey, 2023, Chemical biology & drug design.

3-Substituted-γ-butyrolactones from 5-Trimethylsilyl-2-cyclohexenone. Synthesis of (−)-Enterolactone

Kunihisa Shima, N. Fujii, H. Takei, 1988 .