Lori Ferrins

发表

PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening

George Nikolakopoulos, Jonathan B. Baell, Lori Ferrins, 2013 .

A diverse view of science to catalyse change

Fun Man Fung, César A. Urbina-Blanco, J. F. Stoddart, 2020 .

A diverse view of science to catalyse change

Fun Man Fung, César A. Urbina-Blanco, J. F. Stoddart, 2020, Nature Chemistry.

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.

J. Baell, V. Avery, S. Charman, 2013, European journal of medicinal chemistry.

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents

F. Gamarro, C. Caffrey, D. González-Pacanowska, 2019, PLoS neglected tropical diseases.

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2

Russell B. Davidson, D. Sterner, S. Pokhrel, 2022, Nature Communications.

Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome

M. Cipriano, S. Hajduk, Lori Ferrins, 2022, iScience.

Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity.

Travis J DeLano, F. Gamarro, D. González-Pacanowska, 2020, RSC medicinal chemistry.

A Diverse View of Science to Catalyse Change†

Fun Man Fung, César A. Urbina-Blanco, J. F. Stoddart, 2020, Angewandte Chemie.

Drug Discovery and Development for Kinetoplastid Diseases

Kimberley M. Zorn, Daniel H. Foil, S. Ekins, 2021 .

Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation.

Lori Ferrins, M. Pollastri, R. Sciotti, 2018, ACS infectious diseases.

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei.

Christel A. S. Bergström, J. Baell, V. Avery, 2014, Journal of medicinal chemistry.

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.

Ana Rodriguez, K. Read, J. Baell, 2016, Journal of medicinal chemistry.

Nuisance compounds in cellular assays.

Jayme L. Dahlin, Bruce K. Hua, J. Baell, 2021, Cell chemical biology.

Anilinoquinoline based inhibitors of trypanosomatid proliferation

Ana Rodriguez, Jessey Erath, Lori Ferrins, 2018, PLoS neglected tropical diseases.

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Ivan G. Costa, Vincent A. Voelz, Matthew F. D. Hurley, 2021, Cell Stem Cell.

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

K. Read, J. Baell, M. McConville, 2016, Metabolomics.

Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.

F. Gamarro, C. Caffrey, D. Gonzalez Pacanowska, 2021, Journal of medicinal chemistry.

Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis

F. Gamarro, C. Caffrey, D. Gonzalez Pacanowska, 2019, Journal of medicinal chemistry.

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors.

J. Baell, V. Avery, S. Charman, 2015, Journal of medicinal chemistry.

Drug discovery and human African trypanosomiasis: a disease less neglected?

J. Baell, Raphaël Rahmani, Lori Ferrins, 2013, Future medicinal chemistry.

Functional Characterization of Structural Genomics Proteins in the Crotonase Superfamily

Caitlyn L. Mills, M. Ondrechen, P. Beuning, 2015, ACS chemical biology.

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2

Russell B. Davidson, M. Head, A. Joachimiak, 2021, Research square.

Drug Discovery and Development for Human African Trypanosomiasis

Lori Ferrins, Lori Ferrins, Andrew Spaulding, 2019, Neglected Tropical Diseases.

Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.

Ana Rodriguez, Baljinder Singh, J. Momper, 2018, Journal of medicinal chemistry.

The Importance of Collaboration between Industry, Academics, and Nonprofits in Tropical Disease Drug Discovery.

Lori Ferrins, M. Pollastri, 2017, ACS infectious diseases.

A Diverse View of Science to Catalyse Change.

Fun Man Fung, César A. Urbina-Blanco, J. F. Stoddart, 2020, Journal of the American Chemical Society.

Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors

David D. L. Minh, Vincent A. Voelz, Matthew F. D. Hurley, 2023, bioRxiv.

Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis.

M. Todd, Ben Perry, E. Tse, 2023, ACS infectious diseases.

Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.

R. F. Campbell, Ana Rodriguez, J. McKerrow, 2020, ACS medicinal chemistry letters.

Hit-to-lead optimization of benzoxazepinoindazoles as human African trypanosomiasis therapeutics.

F. Gamarro, C. Caffrey, Lori Ferrins, 2019, Journal of medicinal chemistry.

Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes

D. Kyle, F. Gamarro, D. González-Pacanowska, 2023, Frontiers in Microbiology.

Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi.

Ana Rodriguez, J. Baell, V. Avery, 2019, ACS medicinal chemistry letters.

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors.

J. Baell, V. Avery, S. Charman, 2015, Journal of medicinal chemistry.

Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2

Jerry M. Parks, Russell B. Davidson, D. Sterner, 2023, Nature Communications.

A Diverse View of Science to Catalyse Change

Fun Man Fung, César A. Urbina-Blanco, P. Thordarson, 2020, Angewandte Chemie.

Structure − Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis

E. Tse, G. Caljon, Lori Ferrins, 2022 .

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Ivan G. Costa, Vincent A. Voelz, Matthew F. D. Hurley, 2021, Cell Stem Cell.