Wen-Cherng Lee

发表

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.

Daniel A Erlanson, D. M. Penny, Lihong Sun, 2011, Bioorganic & medicinal chemistry letters.

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

T. Hahn, E. Akporiaye, A. Weinberg, 2012, Cancer Immunology, Immunotherapy.

A Small Molecule α4β1/α4β7 Antagonist Differentiates between the Low-Affinity States of α4β1 and α4β7: Characterization of Divalent Cation Dependence

S. D. de Laszlo, P. Detmers, C. Raab, 2003, Journal of Pharmacology and Experimental Therapeutics.

Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma.

Juswinder Singh, R. Petter, R. Pepinsky, 2004, Current topics in medicinal chemistry.

A Novel Small-Molecule Inhibitor of Transforming Growth Factor B Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

Juswinder Singh, S. Albelda, M. Corbley, 2007 .

Recurrence after Surgical Resection and Prevents Tumor In vivo Mesothelioma Tumor Growth Type I Receptor Kinase ( SM 16 ) Inhibits Murine β Factor A Novel Small-Molecule Inhibitor of Transforming Growth

Juswinder Singh, S. Albelda, M. Corbley, 2007 .

Pyrazolone based TGFbetaR1 kinase inhibitors.

C. Chuaqui, K. Guckian, P. Boriack-Sjodin, 2010, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Analysis of a Polyethelene Glycol-Modified (PEGylated) Small Molecule Inhibitor of Integrin α4β1 with Improved Pharmaceutical Properties

B. Dolinski, R. Petter, R. Pepinsky, 2005, Journal of Pharmacology and Experimental Therapeutics.

Duplexed, bead‐based competitive assay for inhibitors of protein kinases

Susan M. Young, B. Edwards, L. Sklar, 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.

K. Guckian, T. Macdonald, R. Scannevin, 2010, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).

L. Silvian, D. Aivazian, Lin Zhang, 2011, Bioorganic & medicinal chemistry letters.

Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3).

Biswanath De, Wen-Cherng Lee, R. Bookland, 2007, Bioorganic & medicinal chemistry letters.

An abiotic strategy for the enantioselective synthesis of erythromycin B.

A. Hodgson, P. Hergenrother, S. Martin, 2003, Angewandte Chemie.

Pyridinonyl-pdk1-hemmer

K. Guckian, N. Pathan, D. Erlanson, 2007 .

A modified Curtius reaction: an efficient and simple method for direct isolation of free amine

Wen-Cherng Lee, B. Ma, 2010 .

Heat shock protein 90: inhibitors in clinical trials.

R. Scannevin, D. Perret, M. Biamonte, 2010, Journal of medicinal chemistry.

2-Aminoimidazoles inhibitors of TGF-beta receptor 1.

C. Chuaqui, P. Boriack-Sjodin, L. Ling, 2009, Bioorganic & medicinal chemistry letters.

Transforming the TGFbeta pathway: convergence of distinct lead generation strategies on a novel kinase pharmacophore for TbetaRI (ALK5).

Juswinder Singh, Faming Zhang, J. Yingling, 2004, Current opinion in drug discovery & development.

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

Juswinder Singh, S. Albelda, M. Corbley, 2007 .

A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection.

Juswinder Singh, S. Albelda, M. Corbley, 2007, Cancer research.

A Kinase‐focused Compound Collection: Compilation and Screening Strategy

Jessica Friedman, Patrick Cullen, Jason Donnelly, 2006, Chemical biology & drug design.

SM16, an Orally Active TGF-&bgr; Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model

C. Chuaqui, Juswinder Singh, Miki N. Newman, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury.

M. Anscher, Ž. Vujašković, M. Corbley, 2008, International journal of radiation oncology, biology, physics.

An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer.

Raymond B. Runyan, D. Besselsen, D. Mahadevan, 2009, Anticancer research.

Intracellular TGF-β Receptor Blockade Abrogates Smad-Dependent Fibroblast Activation In Vitro and In Vivo

Scott Bowes, Serene Josiah, Juswinder Singh, 2006 .

Evidence That Ligand and Metal Ion Binding to Integrin α4β1 Are Regulated through a Coupled Equilibrium*

A. Whitty, R. Petter, R. Pepinsky, 2001, The Journal of Biological Chemistry.

3D QSAR (COMFA) of a series of potent and highly selective VLA-4 antagonists

Herman van Vlijmen, Charles Hammond, Craig Zimmerman, 2002, J. Comput. Aided Mol. Des..

Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo.

Scott Bowes, Serene Josiah, Juswinder Singh, 2006, The Journal of investigative dermatology.

A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.

S. D. de Laszlo, P. Detmers, C. Raab, 2003, The Journal of pharmacology and experimental therapeutics.

Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI).

Scott Bowes, Serene Josiah, Juswinder Singh, 2003, Bioorganic & medicinal chemistry letters.

Tgf-beta type I receptor (Alk5) kinase inhibitors in oncology.

L. Ling, Wen-Cherng Lee, 2011, Current pharmaceutical biotechnology.

Identification of Potent and Novel α4β1 Antagonists Using in Silico Screening

Herman W. T. van Vlijmen, Juswinder Singh, Juswinder Singh, 2002 .

Corrections to Heat Shock Protein 90: Inhibitors in Clinical Trials

R. Scannevin, D. Perret, M. Biamonte, 2010 .

Strategies for TGF-β modulation: a review of recent patents

Wen-Cherng Lee, D. Bonafoux, 2009, Expert opinion on therapeutic patents.

Successful shape-Based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)

C. Chuaqui, Juswinder Singh, Miki N. Newman, 2003 .

Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury.

M. Anscher, Ž. Vujašković, M. Corbley, 2008, International journal of radiation oncology, biology, physics.