D. Scott

发表

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.

Daniel A Erlanson, D. M. Penny, Lihong Sun, 2011, Bioorganic & medicinal chemistry letters.

Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma.

Juswinder Singh, R. Petter, R. Pepinsky, 2004, Current topics in medicinal chemistry.

Inhibition of LFA‐1/ICAM Interaction for the Treatment of Autoimmune Diseases

K. Guckian, D. Scott, 2013 .

Design, Synthesis, and Analysis of a Polyethelene Glycol-Modified (PEGylated) Small Molecule Inhibitor of Integrin α4β1 with Improved Pharmaceutical Properties

B. Dolinski, R. Petter, R. Pepinsky, 2005, Journal of Pharmacology and Experimental Therapeutics.

Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.

K. Guckian, T. Macdonald, R. Scannevin, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors.

K. Guckian, D. Chin, L. Silvian, 2008, Bioorganic & medicinal chemistry letters.

Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors.

H. V. van Vlijmen, K. Guckian, D. Chin, 2008, Bioorganic & medicinal chemistry letters.

Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.

L. Silvian, T. Bohnert, D. Erlanson, 2019, Bioorganic & medicinal chemistry.

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model.

George H Vandeveer, N. Powell, L. Silvian, 2022, Bioorganic & medicinal chemistry letters.

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.

Y. Liu, L. Silvian, T. Bohnert, 2021, Bioorganic & medicinal chemistry.

Evidence That Ligand and Metal Ion Binding to Integrin α4β1 Are Regulated through a Coupled Equilibrium*

A. Whitty, R. Petter, R. Pepinsky, 2001, The Journal of Biological Chemistry.