Wenjin Yang

发表

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.

Daniel A Erlanson, D. M. Penny, Lihong Sun, 2011, Bioorganic & medicinal chemistry letters.

Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 823.

D. Erlanson, S. Hansen, R. Elling, 2009 .

Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.

D. Erlanson, S. Hansen, R. Elling, 2009 .

Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.

Jian Sun, Wanli Lu, Jian Sun, 2006, Journal of medicinal chemistry.

2-Aminobenzimidazoles as potent Aurora kinase inhibitors.

Amy D. Fung, T. O'Brien, W. Flanagan, 2009, Bioorganic & medicinal chemistry letters.

Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions

J. Rainier, D. Arnaiz, Wenjin Yang, 1994 .

Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions.

J. Rainier, D. Arnaiz, Wenjin Yang, 1995 .

Water-soluble prodrugs of an Aurora kinase inhibitor.

Amy D. Fung, R. Mcdowell, J. Jacobs, 2009, Bioorganic & medicinal chemistry letters.

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II

Michelle R. Arkin, Andrew Conroy, Robert S. McDowell, 2010, PloS one.

P-3A and (−)-desacetamido P-3A: demonstration and Study of their effective functional cleavage of duplex DNA

D. Boger, Wenjin Yang, 1992 .

Deglyco GABA-Gly-desacetamidobleomycin A2: a simplified synthetic model for bleomycin A2

D. Boger, Q. Dang, Wenjin Yang, 1992 .

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency.

A. Simon, G. McGaughey, J. Barrow, 2015, Bioorganic & medicinal chemistry letters.

A simple method for the purification and isolation of bleomycin A2

D. Boger, Wenjin Yang, Royce F. Menezes, 1992 .

Para-quinone methide initiated intramolecular electrophilic substitution reactions

H. L. Mattson, Wenjin Yang, S. R. Angle, 1989 .

Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.

Jian Sun, D. M. Penny, Wanli Lu, 2009, Biochemistry.

Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system.

C. J. Murray, Avinash Gill, E. Zimmerman, 2014, Bioconjugate chemistry.

Identification of nonpeptidic small-molecule inhibitors of interleukin-2.

M. Arkin, R. Mcdowell, J. Oslob, 2005, Bioorganic & medicinal chemistry letters.

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.

R. Fucini, I. C. Choong, Joshua C. Yoburn, 2008, Bioorganic & medicinal chemistry letters.

Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.

L. Silvian, T. Bohnert, D. Erlanson, 2019, Bioorganic & medicinal chemistry.

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.

Y. Liu, L. Silvian, T. Bohnert, 2021, Bioorganic & medicinal chemistry.

Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.

R. Fucini, R. Elling, W. Lew, 2008, Bioorganic & medicinal chemistry letters.

Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme.

R. Fucini, K. Paulvannan, R. Elling, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

pH-Dependent stability and reactivity of a thiol-quinone methide adduct

Wenjin Yang, S. R. Angle, 1992 .