A. Billich

发表

Nortropinyl-arylsulfonylureas as novel, reversible inhibitors of human steroid sulfatase.

P. Nussbaumer, D. Geyl, A. Horvath, 2003, Bioorganic & medicinal chemistry letters.

N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase.

P. Nussbaumer, P. Lehr, B. Wolff, 2005, Bioorganic & medicinal chemistry letters.

Second generation S1P pathway modulators: research strategies and clinical developments.

V. Brinkmann, A. Billich, D. Guerini, 2014, Biochimica et biophysica acta.

The role of sphingosine and ceramide kinases in inflammatory responses.

A. Billich, F. Bornancin, T. Baumruker, 2005, Immunology letters.

Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice.

B. Zemann, A. Billich, F. Bornancin, 2007, Immunology letters.

Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption.

A. Billich, F P Schmook, J G Meingassner, 2001, International journal of pharmaceutics.

Binding of Pimecrolimus and Tacrolimus to Skin and Plasma Proteins: Implications for Systemic Exposure after Topical Application

A. Stuetz, A. Billich, T. Moenius, 2008, Drug Metabolism and Disposition.

Pimecrolimus permeates less than tacrolimus through normal, inflamed, or corticosteroid‐pretreated skin

A. Stuetz, A. Billich, H. Aschauer, 2005, Experimental dermatology.

6-[2-(Adamantylidene)-hydroxybenzoxazole]-O-sulfamate, a steroid sulfatase inhibitor for the treatment of androgen- and estrogen-dependent diseases

E. Schreiner, P. Nussbaumer, A. Winiski, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog

B. Rosenwirth, P. Hiestand, A. Billich, 1994, Antimicrobial Agents and Chemotherapy.

S-1360 Shionogi-GlaxoSmithKline.

A. Billich, 2003, Current opinion in investigational drugs.

The N-terminal region of HIV-1 integrase is required for integration activity, but not for DNA-binding.

M. Schauer, A. Billich, 1992, Biochemical and biophysical research communications.

The non-immunosuppressive cyclosporin A analogue SDZ NIM 811 inhibits cyclophilin A incorporation into virions and virus replication in human immunodeficiency virus type 1-infected primary and growth-arrested T cells.

A. Steinkasserer, B. Rosenwirth, A. Billich, 1997, The Journal of general virology.

HIV-1 Integrase: High-Level Production and Screening Assay for the Endonucleolytic Activity

M. Schauer, B. Rosenwirth, A. Billich, 1992 .

Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions

B. Rosenwirth, V. Quesniaux, A. Billich, 1995, Journal of virology.

A critical β6–β7 loop in the pleckstrin homology domain of ceramide kinase

M. Jaritz, S. Höfinger, A. Billich, 2006 .

Neutropenia with Impaired Immune Response to Streptococcus pneumoniae in Ceramide Kinase-Deficient Mice

P. V. Van Veldhoven, B. Kinzel, B. Zemann, 2008, The Journal of Immunology.

Ceramide Kinase-Deficient Mice in Streptococcus pneumoniae Response to Neutropenia with Impaired Immune

Reichel, B. Kinzel, B. Zemann, 2008 .

Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor

A. Billich, F. Bornancin, M. Klumpp, 2008, Molecular Pharmacology.

Partial Deficiency of Sphingosine-1-Phosphate Lyase Confers Protection in Experimental Autoimmune Encephalomyelitis

Matthias Mueller, B. Nuesslein-Hildesheim, C. Beerli, 2013, PloS one.

Activity with a New Mechanism of Action Compound Showing Immunosuppressive Sanglifehrin A , a Novel Cyclophilin-Binding and

M. Zurini, V. Brinkmann, A. Enz, 2001 .

Sanglifehrin A, a Novel Cyclophilin-Binding Compound Showing Immunosuppressive Activity with a New Mechanism of Action

M. Zurini, V. Brinkmann, V. Quesniaux, 2001, The Journal of Immunology.

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

R. Proia, T. Graf, T. Junt, 2012, The Journal of experimental medicine.

Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis

E. Persohn, C. A. Foster, C. Beerli, 2007, Journal of Pharmacology and Experimental Therapeutics.

Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis.

C. Beerli, C. Bergsdorf, A. Billich, 2014, Journal of medicinal chemistry.

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors

R. Wolf, A. Hofmann, C. Bergsdorf, 2017, Scientific Reports.

In vitro activity of inhibitors of late stages of the replication of HIV in chronically infected macrophages

B. Rosenwirth, S. Aquaro, C. Perno, 1994, Journal of leukocyte biology.

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis

V. Brinkmann, A. Billich, T. Baumruker, 2007, Expert opinion on investigational drugs.

Steroid sulfatase in the human hair follicle concentrates in the dermal papilla.

A. Rot, A. Billich, R. Hoffmann, 2001, The Journal of investigative dermatology.

Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses.

G. Zlabinger, T. Kopp, G. Stingl, 2007, Cellular signalling.

Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells.

A. Billich, T. Baumruker, N. Urtz, 2009, The international journal of biochemistry & cell biology.

Steroid sulfatase inhibitors

P. Nussbaumer, A. Billich, 2003, Medicinal research reviews.

Enzymatic synthesis of cyclosporin A.

A. Billich, R. Zocher, 1987, The Journal of biological chemistry.

N-Methyltransferase function of the multifunctional enzyme enniatin synthetase

A. Billich, R. Zocher, 1987 .

Effects of ceramide-1-phosphate on cultured cells: dependence on dodecane in the vehicles⃞ Published, JLR Papers in Press, October 3, 2006.

F. Staedtler, M. Jaritz, A. Winiski, 2007, Journal of Lipid Research.

Cover Picture: BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution (ChemMedChem 4/2011)

E. Briard, Y. Auberson, M. Streiff, 2011 .

BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution

E. Briard, Y. Auberson, M. Streiff, 2011, ChemMedChem.

Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2.

P. Ettmayer, P. Nussbaumer, A. Billich, 2004, Bioorganic & medicinal chemistry letters.

Fluorescence-based assay of sphingosine kinases.

P. Ettmayer, A. Billich, 2004, Analytical biochemistry.

Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.

G. Charron, S. Hanessian, A. Billich, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of borondipyrromethene (BODIPY)-labeled sphingosine derivatives by cross-metathesis reaction.

T. Ullrich, P. Nussbaumer, A. Billich, 2007, The Journal of organic chemistry.

Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation

S. Côté, F. Pognan, P. Moulin, 2015, Toxicologic pathology.

FTY720‐phosphate is dephosphorylated by lipid phosphate phosphatase 3

G. Zlabinger, A. Billich, F. Bornancin, 2007, FEBS letters.

Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors.

C. Beerli, A. Billich, E. Loetscher, 2013, Analytical biochemistry.

Synthesis and biological evaluation of the first N-alkyl cage dimeric 4-aryl-1,4-dihydropyridines as novel nonpeptidic HIV-1 protease inhibitors.

A. Hilgeroth, M. Wiese, A. Billich, 1999, Journal of medicinal chemistry.

4,5,6‐Trisubstituted Piperidinones as Conformationally Restricted Ceramide Analogues: Synthesis and Evaluation as Inhibitors of Sphingosine and Ceramide Kinases and as NKT Cell‐Stimulatory Antigens

A. Vasella, P. Nussbaumer, A. Billich, 2009, Chemistry & biodiversity.

Drug evaluation: apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency.

A. Billich, 2007, IDrugs : the investigational drugs journal.

Inhibitors of HIV-1 proteinase containing 2-heterosubstituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, enzyme inhibition, and antiviral activity.

E. Schreiner, P. Ettmayer, B. Rosenwirth, 1994, Journal of medicinal chemistry.

Synthesis and biological evaluation of first N-alkyl syn dimeric 4-aryl-1,4-dihydropyridines as competitive HIV-1 protease inhibitors.

H. Lilie, A. Hilgeroth, A. Billich, 2001, European journal of medicinal chemistry.

2-Substituted 4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase.

P. Nussbaumer, P. Lehr, A. Billich, 2002, Journal of medicinal chemistry.

2-(1-adamantyl)-4-(thio)chromenone-6-carboxylic acids: potent reversible inhibitors of human steroid sulfatase.

P. Nussbaumer, A. Horvath, B. Wolff, 2004, Journal of medicinal chemistry.

Backbone Stabilized Peptidomimetics Containing Statine-Like Structural Elements: Diastereospecific Synthesis of Trisubstituted Cyclic Ureas and 1,4-Diazepan-2-ones

A. Billich, D. Scholz, P. Hecht, 1999 .

Synthesis of β3‐Homophenylalanine‐Derived Amino Acids and Peptides by Suzuki Coupling in Solution and on Solid Support

D. Seebach, J. Frackenpohl, A. Billich, 2006 .

Potent and Orally Bioavailable HIV-1 Proteinase Inhibitors Containing the 2-aminobenzylstatine Moiety

B. Rosenwirth, B. Charpiot, H. Gstach, 1995 .

SDZ PRI 053, an orally bioavailable human immunodeficiency virus type 1 proteinase inhibitor containing the 2-aminobenzylstatine moiety

P. Ettmayer, B. Rosenwirth, H. Gstach, 1995, Antimicrobial agents and chemotherapy.

HIV proteinase inhibitors containing 2-aminobenzylstatine as a novel scissile bond replacement: biochemical and pharmacological characterization.

B. Rosenwirth, B. Charpiot, H. Gstach, 1994, Antiviral research.

Synthesis of 7‐Aza‐ and 7‐Thiasphingosines, and Evaluation of Their Interaction with Sphingosine Kinases and with T‐Cells

A. Vasella, P. Nussbaumer, A. Billich, 2009, Chemistry & biodiversity.

Cage Dimeric N‐Acyl‐ and N‐Acyloxy‐4‐aryl‐1,4‐dihydropyridines as First Representatives of a Novel Class of HIV‐1 Protease Inhibitors

A. Hilgeroth, A. Billich, 1999, Archiv der Pharmazie.

Synthesis and Evaluation of Sphingolipid Analogues

A. Vasella, P. Nussbaumer, A. Billich, 2009, Chemistry & biodiversity.

Cage Dimeric N-Acyl- and N-Acyloxy-4-aryl-1,4-dihydropyridines as First Representatives of a Novel Class of HIV-1 Protease Inhibitors.

A. Hilgeroth, A. Billich, 2000 .

Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease.

K. Mann, A. Billich, H. Schramm, 1991, Biochemical and biophysical research communications.

Percutaneous absorption of drugs used in atopic eczema: pimecrolimus permeates less through skin than corticosteroids and tacrolimus.

A. Aszódi, A. Stuetz, A. Billich, 2004, International journal of pharmaceutics.

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.

Cihan Çetin, K. Seuwen, F. Zécri, 2009, Nature chemical biology.

Nucleoside phosphotransferase from malt sprouts. I. Isolation, characterization and specificity of the enzyme.

A. Billich, H. Witzel, U. Stockhowe, 1986, Biological chemistry Hoppe-Seyler.

The effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superficial keratitis in dogs: results from an exploratory study.

A. Billich, B. Nell, J. Meingassner, 2005, Veterinary ophthalmology.

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

Volker Brinkmann, Pascale Burtin, G. Francis, 2010, Nature Reviews Drug Discovery.

Constitutive Expression of Enniatin Synthetase during Fermentative Growth of Fusarium scirpi

A. Billich, R. Zocher, 1988, Applied and environmental microbiology.

Analysis of subsite preferences of HIV-1 proteinase using MA/CA junction peptides substituted at the P3-P1' positions.

A. Billich, G. Winkler, 1991, Archives of biochemistry and biophysics.

Purification, assay and kinetic features of HIV-1 proteinase.

A. Billich, F. Hammerschmid, G. Winkler, 1990, Biological chemistry Hoppe-Seyler.

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

G. Francis, V. Brinkmann, R. Schmouder, 2010, Nature Reviews Drug Discovery.

Entecavir (Bristol-Myers Squibb).

A. Billich, 2001, Current opinion in investigational drugs.

Confocal fluorescence detection expanded to UV excitation: the first continuous fluorimetric assay of human steroid sulfatase in nanoliter volume.

M. Auer, P. Nussbaumer, A. Billich, 2004, Assay and drug development technologies.

Microtiter plate cellular assay for human steroid sulfatase with fluorescence readout.

P. Nussbaumer, B. Wolff, A. Billich, 2003, Analytical biochemistry.

Stimulation of MCF-7 breast cancer cell proliferation by estrone sulfate and dehydroepiandrosterone sulfate: inhibition by novel non-steroidal steroid sulfatase inhibitors

P. Nussbaumer, P. Lehr, A. Billich, 2000, The Journal of Steroid Biochemistry and Molecular Biology.

New fluorogenic substrate for the first continuous steroid sulfatase assay.

M. Auer, P. Nussbaumer, A. Billich, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and Immobilization of erythro‐C14‐ω‐Aminosphingosine‐1‐phosphate as a Potential Tool for Affinity Chromatography

T. Ullrich, P. Nussbaumer, A. Billich, 2008, ChemMedChem.

Nucleoside Phosphotransferase and Nuclease S1 Two Enzymes with Acylphosphate Intermediates, But Different Mechanisms

O. Creutzenberg, A. Billich, H. Witzel, 1988 .

Thymosin alpha1. SciClone Pharmaceuticals.

A. Billich, 2002, Current opinion in investigational drugs.

Kinetic and Binding Studies on [125I]SDZ-283471, A Radiolabeled Inhibitor of Hiv-1 Proteinase

B. Charpiot, H. Gstach, P. Lehr, 1993 .

Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.

Dieter Huesken, F. Natt, A. Billich, 2005, Cellular signalling.

Interferon regulatory factor 5 and nuclear factor kappa‐B exhibit cooperating but also divergent roles in the regulation of pro‐inflammatory cytokines important for the development of TH1 and TH17 responses

B. Kinzel, T. Stein, A. Billich, 2018, The FEBS journal.

Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication

B. Wolff, A. Steinkasserer, G. Werner, 1995, Journal of virology.

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.

S. Hintermann, D. Theil, D. Patel, 2017, JCI insight.

Structure-based and property-driven optimization of N-aryl imidazoles towards potent and selective oral RORγt inhibitors.

S. Hintermann, P. Ertl, M. Streiff, 2019, Journal of medicinal chemistry.

Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.

S. Hintermann, R. Wolf, A. Vulpetti, 2018, Journal of medicinal chemistry.

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

B. Kinzel, B. Zemann, A. Billich, 2006, Blood.

Production of protoplasts from Fusarium scirpi by lytic enzymes from Streptomyces tsusimaensis

A. Billich, U. Keller, H. Kleinkauf, 1988, Applied Microbiology and Biotechnology.

HPV vaccine MedImmune/GlaxoSmithKline.

A. Billich, 2003, Current opinion in investigational drugs.

PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.

John A. Tallarico, Jeffrey A. Porter, P. De Camilli, 2013, Chemistry & biology.

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo

S. Hintermann, K. Kaupmann, J. Kallen, 2017, PloS one.

Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases*

A. Billich, F. Bornancin, T. Baumruker, 2003, Journal of Biological Chemistry.

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors

R. Wolf, A. Hofmann, C. Bergsdorf, 2017, Scientific Reports.

Presence of Cyclophilin A in Synovial Fluids of Patients with Rheumatoid Arthritis

A. Rot, A. Billich, P. Peichl, 1997, The Journal of experimental medicine.

Characterization of a ceramide kinase-like protein.

A. Billich, F. Bornancin, T. Baumruker, 2005, Biochimica et biophysica acta.

Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo.

J. Pfeilschifter, E. Persohn, A. Huwiler, 2015, Circulation research.

Novel cyclosporin derivatives featuring enhanced skin penetration despite increased molecular weight.

A. Stuetz, A. Billich, F. Schmook, 2005, Bioorganic & medicinal chemistry.

Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice

A. Billich, F. Bornancin, T. Baumruker, 2010, Lipids in Health and Disease.

X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations.

R. Dutzler, M. Auer, O. Steinhauser, 1999, Journal of molecular biology.

Assay to measure the secretion of sphingosine-1-phosphate from cells induced by S1P lyase inhibitors.

C. Beerli, A. Billich, E. Loetscher, 2013, Biochemical and biophysical research communications.

Estrone formate: a novel type of irreversible inhibitor of human steroid sulfatase.

E. Schreiner, A. Billich, 2004, Bioorganic & medicinal chemistry letters.

Cage Dimeric 4‐Aryl‐1,4‐dihydropyridines as Promising Lead Structures for the Development of a Novel Class of HIV‐1 Protease Inhibitors

A. Billich, Andreas Hilgeroth, 1999, Archiv der Pharmazie.

Efficient Elimination of Nonstoichiometric Enzyme Inhibitors from HTS Hit Lists

David Beer, Martin Klumpp, Christian Ostermeier, 2009, Journal of biomolecular screening.

Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase

A. Olivera, J. Rivera, A. Billich, 2004, Molecular and Cellular Biology.

Estrogenic potential of 2-alkyl-4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase.

P. Nussbaumer, A. Winiski, A. Billich, 2003, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of New Triazolo‐ and Imidazolopyridine RORγt Inverse Agonists

S. Hintermann, A. Vulpetti, K. Kaupmann, 2016, ChemMedChem.

Sphingolipid metabolizing enzymes as novel therapeutic targets.

A. Billich, T. Baumruker, 2008, Sub-cellular biochemistry.

Assay Systems for HIV-1 Proteinase and Their Use for Evaluation of Inhibitors

B. Rosenwirth, A. Billich, S. Billich, 1991 .

Monoclonal antibodies to the multienzyme enniatin synthetase. Production and use in structural studies.

H. Hochkeppel, D. Lavanchy, A. Billich, 1987, Biological chemistry Hoppe-Seyler.

Phosphorylation by Sphingosine Kinase 2 is Essential for in vivo Potency of FTY720 Analogues

P. Nussbaumer, M. Streiff, C. Pally, 2008, ChemMedChem.

Time-resolved fluorescence anisotropy of HIV-1 protease inhibitor complexes correlates with inhibitory activity.

M. Auer, A. Visser, A. van Hoek, 1998, Biochemistry.

Destruction of ethidium bromide in solution by ozonolysis.

P. Messner, A. Billich, R. Zocher, 1988, Biological chemistry Hoppe-Seyler.

AIDSVAX VaxGen.

A. Billich, 2004, Current opinion in investigational drugs.

Inhibitors of human immunodeficiency virus type 1 protease containing 2-aminobenzyl-substituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, activity, and oral bioavailability.

P. Ettmayer, B. Rosenwirth, B. Charpiot, 1996, Journal of medicinal chemistry.

Ceramide kinase targeting and activity determined by its N-terminal pleckstrin homology domain.

A. Billich, F. Bornancin, T. Baumruker, 2004, Biochemical and biophysical research communications.

alpha 2-Macroglobulin is cleaved by HIV-1 protease in the bait region but not in the C-terminal inter-domain region.

W. Schramm, K. Mann, A. Billich, 1991, Biological Chemistry Hoppe-Seyler.

6-(2-adamantan-2-ylidene-hydroxybenzoxazole)-O-sulfamate: a potent non-steroidal irreversible inhibitor of human steroid sulfatase.

E. Schreiner, A. Winiski, B. Wolff, 2003, Bioorganic & medicinal chemistry letters.

The Cleavage of the Bait Region of α2‐Macroglobulin by Human Immunodeficiency Virus Proteinases and by Astacin

J. Kellermann, K. Mann, U. Meier, 1994, Annals of the New York Academy of Sciences.

Steroid sulfatase inhibitors

A. Horvath, A. Billich, 2005 .

Pharmacological inhibition of stearoyl CoA desaturase in the skin induces atrophy of the sebaceous glands.

A. Winiski, N. Dales, A. Billich, 2013, The Journal of investigative dermatology.

6‐(2‐Adamantan‐2‐ylidene‐hydroxybenzoxazole)‐O‐sulfamate: A Potent Non‐Steroidal Irreversible Inhibitor of Human Steroid Sulfatase.

E. Schreiner, A. Winiski, B. Wolff, 2004 .

Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo

J. Pfeilschifter, E. Persohn, A. Huwiler, 2022 .

Paracyclophanes: a novel class of water-soluble inhibitors of HIV proteinase.

P. Ettmayer, B. Rosenwirth, H. Gstach, 1996, Journal of Medicinal Chemistry.

Paracyclophanes: A Novel Class of Water‐Soluble Inhibitors of HIV Proteinase.

P. Ettmayer, B. Rosenwirth, H. Gstach, 1996 .

Mode of action of SDZ NIM 811, a non-immunosuppressive Cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1)

A. Steinkasserer, B. Rosenwirth, A. Billich, 1995 .

21 New highly potent HIV-1 protease inhibitors

B. Rosenwirth, B. Charpiot, H. Gstach, 1993 .

NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies.

P. Ettmayer, P. Nussbaumer, M. Streiff, 2006, Bioorganic & medicinal chemistry letters.

Bioconversion of ascomycin and its 6-alkoxyderivatives

A. Billich, J. Sanglier, M. Grassberger, 1998 .

Nucleoside phosphotransferase from malt sprouts. II. Studies on the active site and the phospho-intermediate.

A. Billich, H. Witzel, U. Stockhowe, 1986, Biological chemistry Hoppe-Seyler.

Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor Materials and Methods

Basel, A. Billich, B. Oberhauser, 2022 .

Sandoz Research Institute Vienna , Austria Method for Preparation of Epidermal Imprints Using Agarose

J. Schmid, A. Billich, 1999 .

AIDSVAX. VaxGen.

A. Billich, 2001, Current opinion in investigational drugs.