David E Cane

发表

Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry.

Dean J Tantillo, Meimei Xu, D. Cane, 2012, Journal of the American Chemical Society.

Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase.

Chu-Young Kim, Chaitan Khosla, D. Cane, 2006, Journal of the American Chemical Society.

Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.

D. Cane, Chieh-Mei Wang, David E Cane, 2008, Journal of the American Chemical Society.

Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis.

Tiangang Liu, Zixin Deng, Z. Deng, 2006, Chemistry & biology.

Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase.

Chaitan Khosla, Kenji Kinoshita, D. Cane, 2004, Biochemistry.

Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin.

Tiangang Liu, Zixin Deng, Z. Deng, 2008, Chemistry & biology.

Solution structure and proposed domain–domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

Chaitan Khosla, Joseph D Puglisi, J. Puglisi, 2007, Protein science : a publication of the Protein Society.

Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange.

Chaitan Khosla, D. Cane, C. Khosla, 2013, Journal of the American Chemical Society.

X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis*

David J. Miller, D. Cane, D. Christianson, 2008, Journal of Biological Chemistry.

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

Satoshi Omura, Takuma Uchiyama, Haruo Ikeda, 2010, Proceedings of the National Academy of Sciences.

Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site*

Li Lei, Bin Zhao, S. Kelly, 2009, The Journal of Biological Chemistry.

Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase

Chaitan Khosla, D. Cane, C. Khosla, 2010, Proceedings of the National Academy of Sciences.

Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host

Yuuki Yamada, Tadashi Eguchi, Hidehiro Uekusa, 2015, The Journal of Antibiotics.

Exploration and mining of the bacterial terpenome.

Haruo Ikeda, H. Ikeda, D. Cane, 2012, Accounts of chemical research.

Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase.

Chu-Young Kim, Chaitan Khosla, D. Cane, 2004, Biochemistry.

Exploring biosynthetic diversity with trichodiene synthase.

D. Cane, T. Koyama, D. Christianson, 2007, Archives of biochemistry and biophysics.

Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.

Xinqiang Xie, Chaitan Khosla, D. Cane, 2017, Journal of the American Chemical Society.

Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.

Junko Hashimoto, Satoshi Omura, Yuuki Yamada, 2013, ACS synthetic biology.

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

Chu-Young Kim, Chaitan Khosla, D. Cane, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase.

Chaitan Khosla, D. Cane, C. Khosla, 2007, Journal of the American Chemical Society.

X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.

Luigi Di Costanzo, David W Christianson, David E Cane, 2007, Biochemistry.

Understanding Substrate Specificity of Polyketide Synthase Modules by Generating Hybrid Multimodular Synthases*

Kenji Watanabe, Chaitan Khosla, D. Cane, 2003, Journal of Biological Chemistry.

Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases.

Satoshi Yuzawa, Chaitan Khosla, D. Cane, 2012, Biochemistry.

Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases.

Chaitan Khosla, Nicholas Wu, D. Cane, 2002, Biochemistry.

Structure and mechanism of assembly line polyketide synthases.

Chaitan Khosla, D. Cane, C. Khosla, 2016, Current opinion in structural biology.

Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase.

Adrian Keatinge-Clay, Young-Ok You, D. Cane, 2013, Biochemistry.

Programming of Erythromycin Biosynthesis by a Modular Polyketide Synthase*

D. Cane, David E Cane, 2010, The Journal of Biological Chemistry.

Structure-based dissociation of a type I polyketide synthase module.

Chaitan Khosla, D. Cane, C. Khosla, 2007, Chemistry & biology.

Structure and mechanism of the 6-deoxyerythronolide B synthase.

Chaitan Khosla, D. Cane, C. Khosla, 2007, Annual review of biochemistry.

Revisiting the modularity of modular polyketide synthases.

Chaitan Khosla, D. Cane, C. Khosla, 2009, Current opinion in chemical biology.

Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules.

Chaitan Khosla, Marcus Hans, D. Cane, 2003, Journal of the American Chemical Society.

Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase.

Chu-Young Kim, Chaitan Khosla, D. Cane, 2007, Chemistry & biology.