W G Hol

发表

Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin.

E A Merritt, E. Merritt, W. Hol, 1997, Structure.

Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate.

C L Verlinde, M. Noble, C. Verlinde, 1991, Journal of medicinal chemistry.

An accurate numerical model for calculating the equilibration rate of a hanging-drop experiment.

D J Diller, D. Diller, W. Hol, 1999, Acta crystallographica. Section D, Biological crystallography.

Structure of the complex between trypanosomal triosephosphate isomerase and N‐hydroxy‐4‐phosphono‐butanamide: Binding at the active site despite an “open” flexible loop conformation

C L Verlinde, F. Opperdoes, C. Verlinde, 1992, Protein science : a publication of the Protein Society.

Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes.

G Vriend, K S Wilson, G. Vriend, 1989, Journal of molecular biology.

Anion binding at the active site of trypanosomal triosephosphate isomerase. Monohydrogen phosphate does not mimic sulphate.

C L Verlinde, M. Noble, C. Verlinde, 1991, European journal of biochemistry.

Preliminary crystallographic studies of glycosomal glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei.

R J Read, F. Opperdoes, R. Read, 1987, Journal of molecular biology.

Structure determination of the glycosomal triosephosphate isomerase from Trypanosoma brucei brucei at 2.4 A resolution.

K. H. Kalk, R. Wierenga, W. Hol, 1987, Journal of molecular biology.

The crystal structure of the “open” and the “closed” conformation of the flexible loop of trypanosomal triosephosphate isomerase

M. Noble, F. Opperdoes, W. Hol, 1991, Proteins.

Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists.

C L Verlinde, C. Verlinde, W. Hol, 1999, Biochemistry.

Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex.

G Vriend, G. Vriend, M. Noble, 1991, Journal of molecular biology.

Glycolysis as a target for the design of new anti-trypanosome drugs.

C L Verlinde, F. Opperdoes, M. Gelb, 2001, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

The role of waters in docking strategies with incremental flexibility for carbohydrate derivatives: heat-labile enterotoxin, a multivalent test case.

C L Verlinde, D J Diller, C. Verlinde, 1999, Journal of medicinal chemistry.

Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.

N. Xuong, J. Bolin, D. Filman, 1978, Journal of Biological Chemistry.

The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes

M. Noble, F. Opperdoes, W. Hol, 1991, Proteins.

Prediction of the occurrence of the ADP-binding beta alpha beta-fold in proteins, using an amino acid sequence fingerprint.

P. Terpstra, R. Wierenga, W. Hol, 1986, Journal of molecular biology.