Frank-Peter Theil

发表

Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods.

Patrick Poulin, F. Theil, P. Poulin, 2009, Journal of pharmaceutical sciences.

Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

Patrick Poulin, F. Theil, P. Poulin, 2002, Journal of pharmaceutical sciences.

Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response

Harvey Wong, Cornelis E C A Hop, F. Theil, 2012, Clinical Cancer Research.

Effects of charge on antibody tissue distribution and pharmacokinetics.

Kiran Mukhyala, F. Theil, L. Khawli, 2010, Bioconjugate chemistry.

Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling

Harvey Wong, Xiling Song, Cornelis E C A Hop, 2010, Drug Metabolism and Disposition.

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

Walter Schmitt, Stefan Willmann, Andrea N. Edginton, 2008 .

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

Walter Schmitt, Stefan Willmann, Andrea N Edginton, 2008, Expert opinion on drug metabolism & toxicology.

A strategy for risk mitigation of antibodies with fast clearance

Lisa J. Bernstein, Pamela Chan, Isidro Hötzel, 2012, mAbs.

A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human.

Sean Ekins, Patrick Poulin, S. Ekins, 2011, Toxicology and applied pharmacology.

Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition.

Patrick Poulin, F. Theil, P. Poulin, 2002, Journal of pharmaceutical sciences.

Confounding parameters in preclinical assessment of blood-brain barrier permeation: an overview with emphasis on species differences and effect of disease states.

F. Theil, Jean-Marie Nicolas, Frank-Peter Theil, 2013, Molecular pharmaceutics.

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.

Dolores Diaz, Brian Dean, Donna M Dambach, 2013, Journal of pharmaceutical sciences.

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data

Saileta Prabhu, F. Theil, S. Prabhu, 2011, mAbs.

Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans.

Thierry Lavé, Patrick Poulin, F. Theil, 2003, Journal of pharmaceutical sciences.

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

Patrick Poulin, F. Theil, S. Haddad, 2003, Toxicology letters.