S J Benkovic

发表

Combinatorial protein engineering by incremental truncation.

J. H. Shim, S. Benkovic, M. Ostermeier, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant.

C. Cameron, S. Benkovic, S J Benkovic, 1997, Biochemistry.

Predicting crossover generation in DNA shuffling

C D Maranas, C. Maranas, S. Benkovic, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A mass spectrometric solution to the address problem of combinatorial libraries.

S. Benkovic, N. Winograd, C L Brummel, 1994, Science.

Improvement in the efficiency of formyl transfer of a GAR transformylase hybrid enzyme.

S. Benkovic, A. Nixon, A E Nixon, 2000, Protein engineering.

Evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries.

M E Hemling, C L Brummel, N Winograd, 1996, Analytical chemistry.

Kinetic mechanism of DNA polymerase I (Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant.

S. Benkovic, S J Benkovic, M E Dahlberg, 1991, Biochemistry.

Homology-independent protein engineering.

S. Benkovic, S. Lutz, S J Benkovic, 2000, Current opinion in biotechnology.

Metallo-beta-lactamase: structure and mechanism.

Z Wang, S. Benkovic, W. Fast, 1999, Current opinion in chemical biology.

Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library.

R. Lerner, S. Benkovic, W. Huse, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Rapid generation of incremental truncation libraries for protein engineering using alpha-phosphothioate nucleotides.

S. Benkovic, M. Ostermeier, S. Lutz, 2001, Nucleic acids research.

Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket.

R. Lerner, J. Tainer, E. Getzoff, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Evolution of protein function by domain swapping.

S. Benkovic, M. Ostermeier, M Ostermeier, 2000, Advances in protein chemistry.

Mechanism-based inhibition of an essential bacterial adenine DNA methyltransferase: rationally designed antibiotics.

S. Benkovic, D. Wahnon, S J Benkovic, 2001, Journal of the American Chemical Society.

Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.

S. Benkovic, J. Peliska, S J Benkovic, 1992, Science.

Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda.

D R Burton, R. Lerner, D. Burton, 1989, Science.

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.

S. Benkovic, C. Fierke, K. Johnson, 1987, Biochemistry.

A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivo.

S. Benkovic, P. Schimmel, S J Benkovic, 1981, Proceedings of the National Academy of Sciences of the United States of America.

At the crossroads of chemistry and immunology: catalytic antibodies.

P G Schultz, R. Lerner, P. Schultz, 1991, Science.

Identification of the Active Oligomeric State of an Essential Adenine DNA Methyltransferase from Caulobacter crescentus *

S. Benkovic, S J Benkovic, V K Shier, 2001, The Journal of Biological Chemistry.

Production of cyclic peptides and proteins in vivo.

S. Benkovic, D. Wahnon, E. Abel-Santos, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Insights into enzyme function from studies on mutants of dihydrofolate reductase.

S. Benkovic, C. Fierke, S J Benkovic, 1988, Science.

Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism.

P E Wright, H. Dyson, P. Wright, 2001, Biochemistry.

Creating multiple-crossover DNA libraries independent of sequence identity

C D Maranas, C. Maranas, S. Benkovic, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Implications for enzymic catalysis from free-energy reaction coordinate profiles.

S J Benkovic, K A Johnson, C A Fierke, 1987, Cold Spring Harbor symposia on quantitative biology.

Dynamics of a flexible loop in dihydrofolate reductase from Escherichia coli and its implication for catalysis.

P E Wright, P. Wright, S. Benkovic, 1994, Biochemistry.

On the mechanism of the metallo-beta-lactamase from Bacteroides fragilis.

Z Wang, S. Benkovic, W. Fast, 1999, Biochemistry.

Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

C. Barbas, R. Lerner, S. Benkovic, 1991, Proceedings of the National Academy of Sciences of the United States of America.

New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.

D. Boger, I. Wilson, S. Benkovic, 1999, Biochemistry.

Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.

I. Wilson, S. Benkovic, James Inglese, 1992, Journal of molecular biology.

Assembly and disassembly of DNA polymerase holoenzyme.

S. Benkovic, D J Sexton, S J Benkovic, 1997, Current opinion in chemical biology.

Effects of distal point-site mutations on the binding and catalysis of dihydrofolate reductase from Escherichia coli.

R. Matthews, S. Benkovic, J. Adams, 1989, Biochemistry.

Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly.

S. Benkovic, T. Carver, D J Sexton, 1998, Biochemistry.

Glu-111 is required for activation of the DNA cleavage center of EcoRI endonuclease.

S. Benkovic, P. Modrich, P Modrich, 1989, The Journal of biological chemistry.

Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.

I. Wilson, S. Benkovic, C. Klein, 1995, Journal of molecular biology.