Weiru Wang

发表

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

Shenghua Shi, Kam Y. J. Zhang, Sarah Will, 2009, Proceedings of the National Academy of Sciences.

RAF inhibitors that evade paradoxical MAPK pathway activation

James Tsai, Ying Zhang, Paul S. Lin, 2015, Nature.

Characterization of oxidative carbonylation on recombinant monoclonal antibodies.

Christian Schöneich, Cinzia Stella, Lynn Gennaro, 2014, Analytical chemistry.

Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes

Lisa N Kinch, Nick V Grishin, Na Zhang, 2014, Nature Genetics.

Crystal structure of tRNA (m1G37) methyltransferase from Aquifex aeolicus at 2.6 Å resolution: A novel methyltransferase fold

Rosalind Kim, Sung-Hou Kim, H. Yokota, 2003, Proteins.

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.

Yang Xiao, Lei Zhang, Karl H. Clodfelter, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Kam Y. J. Zhang, James Tsai, Nikolas K. Haass, 2008, Proceedings of the National Academy of Sciences.

Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.

Karl H. Clodfelter, Zhongguo Wang, Mark Zak, 2013, Bioorganic & medicinal chemistry letters.

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

Dolores Diaz, Jianping Yin, Michael Burkard, 2016, Journal of medicinal chemistry.

Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

Xukun Chen, Mark Zak, Yongbo Liu, 2014, Chembiochem : a European journal of chemical biology.

High-Throughput Detection of Clinically Relevant Mutations in Archived Tumor Samples by Multiplexed PCR and Next-Generation Sequencing

Richard Bourgon, Rajesh Patel, Yibing Yan, 2014, Clinical Cancer Research.

Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic "snapshots" of intermediate states.

Henry H Nguyen, Rosalind Kim, Sung-Hou Kim, 2002, Journal of molecular biology.

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Yang Xiao, Lei Zhang, Deepak Sampath, 2013, Bioorganic & medicinal chemistry letters.

Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.

Karl H. Clodfelter, Zhongguo Wang, Mark Zak, 2013, Journal of medicinal chemistry.

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.

Xianrui Zhao, Ignacio Aliagas, Ronen Marmorstein, 2015, ACS medicinal chemistry letters.

Targeting protein-protein interaction by small molecules.

Weiru Wang, G. Fang, Weiru Wang, 2014, Annual review of pharmacology and toxicology.