Y Pommier

发表

Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.

M C Nicklaus, Y. Pommier, N. Neamati, 1997, Journal of medicinal chemistry.

Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol.

E. Sausville, Y. Pommier, T. Shimizu, 1998, Blood.

RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors.

Y. Pommier, N. Caplen, R. Guha, 2011, Current cancer drug targets.

Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.

A Wlodawer, T R Burke, Y. Pommier, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Substitutions of Asn-726 in the Active Site of Yeast DNA Topoisomerase I Define Novel Mechanisms of Stabilizing the Covalent Enzyme-DNA Intermediate*

Y. Pommier, M. Bjornsti, P. Pourquier, 2000, The Journal of Biological Chemistry.

HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.

M C Nicklaus, Y. Pommier, N. Neamati, 1997, Journal of medicinal chemistry.

Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin.

K W Kohn, K. Kohn, Y. Pommier, 1993, Nucleic acids research.

Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets.

Alexander D. MacKerell, M C Nicklaus, Y. Pommier, 2000, Bioorganic & medicinal chemistry.

Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.

Y Pommier, M Cushman, G Kohlhagen, 2000, Journal of medicinal chemistry.

Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies.

J N Weinstein, K W Kohn, J. Weinstein, 2001, Journal of medicinal chemistry.

Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.

J N Weinstein, K W Kohn, J. Weinstein, 1995, Journal of medicinal chemistry.

Mechanisms of topoisomerase I inhibition by anticancer drugs.

K W Kohn, K. Kohn, Y. Pommier, 1994, Advances in pharmacology.

Discovery of HIV-1 integrase inhibitors by pharmacophore searching.

M C Nicklaus, T R Burke, Y. Pommier, 1997, Journal of medicinal chemistry.

Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.

K W Kohn, K. Kohn, Y. Pommier, 1991, The Journal of biological chemistry.

Use of camptothecin-resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site.

Y. Pommier, C. Bailly, G. Kohlhagen, 2001, Cancer research.

Potent inhibitors of human immunodeficiency virus type 1 integrase: identification of a novel four-point pharmacophore and tetracyclines as novel inhibitors.

Y. Pommier, N. Neamati, G. Milne, 1997, Molecular pharmacology.

Retroviral integrase inhibitors year 2000: update and perspectives.

Y. Pommier, N. Neamati, C. Marchand, 2000, Antiviral research.

Eukaryotic DNA topoisomerases I.

Y. Pommier, A. Fujimori, Y Pommier, 1995, Biochimica et biophysica acta.

Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.

T R Burke, Y. Pommier, N. Neamati, 1998, Journal of medicinal chemistry.

Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.

Y. Pommier, G. Kohlhagen, J. Jenkins, 1993, The Journal of biological chemistry.

Topoisomerase I-mediated DNA damage.

Y. Pommier, P. Pourquier, Y Pommier, 2001, Advances in cancer research.

Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture.

Y. Pommier, Y Pommier, A Tanizawa, 1992, Cancer research.

Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.

T R Burke, Y. Pommier, N. Neamati, 1996, Journal of medicinal chemistry.

Identification of HIV-1 Integrase Inhibitors Based on a Four-Point Pharmacophore

Y. Pommier, N. Neamati, A. Orr, 1998, Antiviral chemistry & chemotherapy.

Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage.

K W Kohn, K. Kohn, Y. Pommier, 1995, Cancer research.

In vitro human immunodeficiency virus type 1 integrase assays.

Y. Pommier, N. Neamati, C. Marchand, 2001, Methods in enzymology.

Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin.

Y. Pommier, Y. Hoki, G. Kohlhagen, 1995, Cancer research.

Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin.

J N Weinstein, K W Kohn, J. Weinstein, 1998, Journal of medicinal chemistry.