Dennis Huszar

发表

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.

Jon Read, Mei Su, Minwei Ye, 2011, Journal of medicinal chemistry.

Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.

Mei Su, Minwei Ye, C. Chuaqui, 2014, Journal of medicinal chemistry.

Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2*

Tao Wang, Minwei Ye, Nancy Su, 2008, Journal of Biological Chemistry.

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

R. Cone, R. Kesterson, D. Huszar, 1997, Cell.

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia.

Allan Wu, Paul D Lyne, Xiaolan Zheng, 2014, Blood.

Comparisons of the efficacy of a Jak1/2 inhibitor (AZD1480) with a VEGF signaling inhibitor (cediranib) and sham treatments in mouse tumors using DCE-MRI, DW-MRI, and histology.

Thomas E Yankeelov, John C Gore, Mary E Loveless, 2012, Neoplasia.

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

Ming Li, Elisa de Stanchina, Claudio Ceccarelli, 2013, Neoplasia.

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.

Hua Yu, Hong Xin, Minwei Ye, 2009, Cancer cell.