G. Romeo

发表

Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D‐QSAR Coupled to Scaffold‐Hopping Analysis

L. Salerno, A. Rescifina, V. Pittalà, 2018, ChemMedChem.

Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products

L. Salerno, A. Rescifina, V. Pittalà, 2019, Marine drugs.

Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents.

V. Sorrenti, L. Vanella, K. Greish, 2019, Future medicinal chemistry.

Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines.

V. Sorrenti, L. Vanella, R. Turnaturi, 2018, European journal of medicinal chemistry.

A focus on heme oxygenase-1 (HO-1) inhibitors.

L. Salerno, V. Pittalà, G. Romeo, 2013, Current medicinal chemistry.

Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-1.

R. Acquaviva, C. Di Giacomo, V. Sorrenti, 2017, Current pharmaceutical design.

Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors

L. Salerno, A. Rescifina, V. Pittalà, 2017, Data in brief.

Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions.

C. Di Giacomo, V. Sorrenti, L. Vanella, 2017, Current medicinal chemistry.

[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor.

M. Salmona, A. Cagnotto, L. Salerno, 2019, European journal of medicinal chemistry.

Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands.

A. Bojarski, Rafał Kurczab, M. Salmona, 2014, European journal of medicinal chemistry.

Novel (E)-α-[(1H-indol-3-yl)methylene]benzeneacetic acids as endothelin receptor ligands

A. Cagnotto, L. Salerno, V. Pittalà, 2005 .

A facile synthesis of new 2-carboxamido-3-carboxythiophene and 4,5,6,7-tetrahydro-2-carboxamido-3-carboxythieno[2,3-c]pyridine derivatives as potential endothelin receptors ligands.

A. Cagnotto, L. Salerno, V. Pittalà, 2005, Farmaco.

Development of New Benzylpiperazine Derivatives as σ1 Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects

L. Salerno, V. Pittalà, J. McLaughlin, 2021, ACS chemical neuroscience.

Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.

S. Gobbi, R. Smits, I. D. de Esch, 2009, Bioorganic & medicinal chemistry.

Synthesis and binding properties of novel selective 5-HT3 receptor ligands.

A. Cagnotto, F. Fülöp, R. Gáspár, 2004, Bioorganic & medicinal chemistry.

New Pyrimido[5,4-b]indoles as Ligands for α1-Adrenoceptor Subtypes

F. Nicoletti, M. Botta, K. Minneman, 2003 .

Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells

V. Sorrenti, L. Vanella, A. G. D’amico, 2022, International journal of molecular sciences.

Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia

V. Sorrenti, L. Vanella, K. Greish, 2022, Molecules.

An α1-adrenergic receptor ligand repurposed as a potent antiproliferative agent for head and neck squamous cell carcinoma

L. Salerno, A. Rescifina, C. Zagni, 2015 .

Lipid Nanoparticles Traverse Non-Corneal Path to Reach the Posterior Eye Segment: In Vivo Evidence

E. Strettoi, E. Novelli, P. Campiglia, 2021, Molecules.

Progress in the development of selective nitric oxide synthase (NOS) inhibitors.

C. Di Giacomo, V. Sorrenti, L. Salerno, 2002, Current pharmaceutical design.

Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects.

L. Salerno, V. Pittalà, A. Marrazzo, 2022, Bioorganic & medicinal chemistry.

New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies.

Rafał Kurczab, M. Salmona, A. Cagnotto, 2017, Bioorganic & medicinal chemistry.

Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors.

G. Vistoli, A. Pedretti, A. Cagnotto, 2011, Bioorganic & medicinal chemistry.

Synthesis and Receptor Binding of New Thieno[2,3‐d]‐pyrimidines as Selective Ligands of 5‐HT3 Receptors

G. Maksay, A. Cagnotto, L. Salerno, 2008, Archiv der Pharmazie.

Synthesis of novel 5H‐Pyrimido[5,4‐b]mdole‐(1H,3H)2,4‐diones as potential ligands for the cloned α1‐adrenoceptor subtypes

G. Romeo, F. Russo, A. Blasi, 2001 .

Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation.

S. Salomone, F. Drago, L. Salerno, 2015, European journal of pharmacology.

Dipalmitoylphosphatidylcholine/linoleic acid mixed unilamellar vesicles as model membranes for studies on novel free-radical scavengers.

D. Trombetta, F. Bonina, A. Saija, 1997, Journal of pharmacological and toxicological methods.

New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: high affinity ligands for the alpha(1)-adrenoceptor subtypes.

G. Marucci, M. Buccioni, K. Minneman, 2006, Bioorganic & medicinal chemistry letters.

Glucose-Impaired Corneal Re-Epithelialization Is Promoted by a Novel Derivate of Dimethyl Fumarate

G. Li Volti, G. Lupo, G. Giurdanella, 2021, Antioxidants.

Monoolein liquid crystalline phases for topical delivery of crocetin.

P. Mariani, R. Cortesi, E. Esposito, 2018, Colloids and surfaces. B, Biointerfaces.

NMR experiments of oleuropein biomimetic hydrolysis.

N. Uccella, A. Piperno, A. Bianco, 1999, Journal of agricultural and food chemistry.

SYNTHESIS OF NEW THIAZINOINDOLE DERIVATIVES AND THEIR EVALUATION AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE AND OTHER RELATED SERINE PROTEASES

R. Chabin, S. Guccione, G. Romeo, 1994 .

Novel inhibitors of nitric oxide synthase with antioxidant properties.

R. Acquaviva, C. Di Giacomo, V. Sorrenti, 2012, European journal of medicinal chemistry.

Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands.

S. Guccione, G. Romeo, A. de Blasi, 1991, Journal of medicinal chemistry.

Synthesis of new thieno [2,3-d]pyrimidine-2,4(1H,3H)-diones with analgesic and anti-inflammatory activities.

G. Romeo, F. Russo, A. Caruso, 1998, Arzneimittel-Forschung.

Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis.

V. Sorrenti, L. Salerno, A. Rescifina, 2018, Bioorganic chemistry.

Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.

C. Di Giacomo, V. Sorrenti, L. Vanella, 2015, European journal of medicinal chemistry.

Pyrazolothiazolopyrimidine derivatives as a novel class of anti-inflammatory or antinociceptive agents: synthesis, structural characterization and pharmacological evaluation

S. Guccione, G. Romeo, F. Russo, 1993 .

Synthesis of New Thiazinoindole Derivatives and Their Evaluation as Inhibitors of Human Leukocyte Elastase and Other Related Serine Proteases.

R. Chabin, S. Guccione, G. Romeo, 2010 .

Synthesis and pharmacological properties of pyrazolotriazolopyrimidine derivatives

S. Guccione, G. Romeo, F. Russo, 1992 .

Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors.

V. Sorrenti, L. Salerno, A. Rescifina, 2018, European journal of medicinal chemistry.

How does binding of imidazole-based inhibitors to heme oxygenase-1 influence their conformation? Insights combining crystal structures and molecular modelling.

J. de Ruyck, J. Wouters, L. Salerno, 2015, Acta crystallographica Section B, Structural science, crystal engineering and materials.

Clean-up and quantification of abscisic acid from citrus leaves by reversed-phase high-performance liquid chromatography

N. A. Santagati, G. Romeo, E. Bousquet, 1986 .

Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity

V. Sorrenti, L. Vanella, V. D’Agata, 2021, Molecules.

Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.

L. Salerno, V. Pittalà, A. Marrazzo, 2019, European journal of medicinal chemistry.

Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties.

R. Acquaviva, C. Di Giacomo, V. Sorrenti, 2013, Bioorganic & medicinal chemistry.

Synthesis of 1,2,4-triazole derivatives: binding properties on endothelin receptors.

A. Cagnotto, L. Salerno, V. Pittalà, 2007, Medicinal chemistry (Shariqah (United Arab Emirates)).

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

V. Sorrenti, K. Greish, L. Salerno, 2018, Molecules.

Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.

V. Sorrenti, L. Salerno, V. Pittalà, 2017, European journal of medicinal chemistry.

A computer-aided approach to identify novel Leishmania major protein disulfide isomerase inhibitors for treatment of leishmaniasis

Giuseppe Romeo, Valeria Pittalà, Douglas J. Perkins, 2021, Journal of Computer-Aided Molecular Design.

[11C]RN5: A new agent for the in vivo imaging of myocardial α1-adrenoceptors

F. Fazio, R. Moresco, A. Carpinelli, 2002 .

Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective

L. Salerno, V. Pittalà, A. Marrazzo, 2021, Journal of medicinal chemistry.

Examination of the Novel Sigma-1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti-allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use

S. Eans, J. McLaughlin, G. Romeo, 2022, International journal of molecular sciences.

New 1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives: analogues of HEAT as ligands for the alpha1-adrenergic receptor subtypes.

K. Minneman, L. Salerno, V. Pittalà, 2006, Bioorganic & medicinal chemistry.

High-performance liquid chromatography with fluorimetric detection in biological tissues of the 4-bromomethyl-7-methoxycoumarin ester derivative of 5-pyrrolidone-2-carboxylic acid.

G. Romeo, E. Bousquet, L. I. Giannola, 1985, Journal of chromatography.

Heme Oxygenase-1 Inhibition Sensitizes Human Prostate Cancer Cells towards Glucose Deprivation and Metformin-Mediated Cell Death

G. Li Volti, V. Sorrenti, L. Vanella, 2019, International journal of molecular sciences.

[1,2,4]Triazole derivatives as 5-HT(1A) serotonin receptor ligands.

A. Cagnotto, L. Salerno, M. Sarvà, 2002, Bioorganic & medicinal chemistry.

Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.

M. Nowak, A. Bojarski, A. Cagnotto, 2008, Journal of medicinal chemistry.

Analysis of mechanisms for memory enhancement using novel and potent 5-HT1A receptor ligands

L. Salerno, V. Pittalà, G. Romeo, 2015, European Neuropsychopharmacology.

Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE.

T D Perkins, I. D. de Esch, R. Leurs, 2001, Journal of medicinal chemistry.

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands

Giovanni Nastasi, Giuseppe Romeo, Carla Miceli, 2017, Journal of Cheminformatics.

Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands.

S. Chiechio, R. Turnaturi, L. Salerno, 2019, European journal of medicinal chemistry.

Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands

M. Salmona, A. Cagnotto, L. Salerno, 2020, Molecules.

Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.

M. Salmona, A. Cagnotto, L. Salerno, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.

M. Salmona, A. Cagnotto, L. Salerno, 2015, Bioorganic & medicinal chemistry letters.

3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.

G. Marucci, A. Cagnotto, L. Salerno, 2006, Bioorganic & medicinal chemistry letters.

High affinity ligands and potent antagonists for the α1D-adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives.

G. Marucci, M. Buccioni, K. Minneman, 2014, European journal of medicinal chemistry.

Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.

M. Botta, A. Cagnotto, L. Salerno, 2005, Journal of Medicinal Chemistry.

Novel antagonists for α1-adrenoceptor subtypes

K. Minneman, L. Salerno, G. Romeo, 2004 .

5-HT7 receptor ligands: recent developments and potential therapeutic applications.

L. Salerno, V. Pittalà, G. Romeo, 2007, Mini reviews in medicinal chemistry.

Antitumor properties of substituted (αE)-α-(1H-indol-3-ylmethylene)benzeneacetic acids or amides.

V. Cardile, C. Fortuna, L. Salerno, 2013, Bioorganic & medicinal chemistry.

Functionalized g-Lactones via Intramolecular Nitrile Oxide Cycloaddition

A. Rescifina, A. Corsaro, N. Uccella, 1993 .

In Vitro Antioxidant Activity of Idebenone Derivative-Loaded Solid Lipid Nanoparticles

L. Salerno, A. Panico, G. Romeo, 2017, Molecules.

Development of [methoxy-11C]RN5 as a potential radioligand for the in vivo pet measurement of myocardial α1A-adrenoceptors

F. Fazio, R. Moresco, A. Carpinelli, 2001 .

[Synthesis and analgesic activity of 3-substituted derivatives of pyrido [3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-ones].

G. Romeo, E. Bousquet, A. Caruso, 1985, Il Farmaco; edizione scientifica.

Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α₁-adrenoceptor subtypes.

M. Botta, K. Minneman, L. Salerno, 2011, European journal of medicinal chemistry.

Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity

V. Sorrenti, L. Vanella, V. D’Agata, 2021, Journal of medicinal chemistry.

Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors

Giuseppe Romeo, Giovanni Nastasi, Valeria Pittalà, 2017, ChemMedChem.

Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region.

V. Sorrenti, L. Salerno, A. Rescifina, 2020, Bioorganic chemistry.

Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes.

R. Acquaviva, C. Di Giacomo, V. Sorrenti, 2019, Current medicinal chemistry.

Pyrimido[5,4-b]benzofuran and pyrimido[5,4-b]benzothiophene derivatives Ligands for α1-and 5HT1A-receptors

G. Ambrosini, S. Guccione, G. Romeo, 1993 .

Antioxidant Activity and Phenolic Content of Microwave-Assisted Solanum melongena Extracts

R. Acquaviva, C. Di Giacomo, V. Sorrenti, 2014, TheScientificWorldJournal.

Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs

L. Salerno, V. Pittalà, G. Romeo, 2021, ChemMedChem.

1 Structure − Activity Relationships and Therapeutic Potentials of 5 ‑ HT 7 2 Receptor Ligands: An Update

E. Lacivita, L. Salerno, V. Pittalà, 2018 .

Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.

V. Sorrenti, L. Salerno, V. Pittalà, 2017, European journal of medicinal chemistry.

Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.

M. Salmona, A. Cagnotto, L. Salerno, 2015, Bioorganic & medicinal chemistry letters.

Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5‐Fluorouracil and Imidazole‐Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells

V. Sorrenti, L. Vanella, L. Salerno, 2023, ChemMedChem.

Synthesis of new 5-phenyl[1,2,4]triazole derivatives as ligands for the 5-HT1A serotonin receptor

L. Salerno, V. Pittalà, G. Romeo, 2004 .