K. Nakatsu

发表

Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring.

R. Kinobe, J. Brien, G. Roman, 2007, Bioorganic & medicinal chemistry.

X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors.

Z. Jia, M. Rahman, J. Vlahakis, 2008, Journal of medicinal chemistry.

X-ray crystal structure of human heme oxygenase-1 with (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode.

Z. Jia, M. Rahman, J. Vlahakis, 2009, Journal of medicinal chemistry.

Quantitation of nitric oxide formation from nitrovasodilator drugs by chemiluminescence analysis of headspace gas.

J. Brien, K. Nakatsu, B. McLaughlin, 1991, Journal of pharmacological methods.

Does carbon monoxide have a physiological function?

K Nakatsu, J. Brien, K. Nakatsu, 1991, Trends in pharmacological sciences.

Do adenine derivatives have a special role in biological regulation?

K. Nakatsu, 1978, Medical hypotheses.

Nitric oxide formation from glyceryl trinitrate by rabbit aortic strip: detection by rabbit taenia coli concurrent with vasorelaxation

J. Brien, K. Nakatsu, M. Poklewska-Koziell, 1994, British journal of pharmacology.

A novel method for detection of nitric oxide binding sites by using a chemiluminescence-headspace gas technique.

J. Brien, K. Nakatsu, B. McLaughlin, 1993, Journal of pharmacological and toxicological methods.

Differential biotransformation of glyceryl trinitrate by red blood cell-supernatant fraction and pulmonary vein homogenate.

J. Brien, K. Nakatsu, B. McLaughlin, 1989, Canadian journal of physiology and pharmacology.

Limitation of theophylline elimination by reduced oxygen availability in mouse hepatocytes and rat isolated livers.

K. Nakatsu, 1985, Canadian journal of physiology and pharmacology.

Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta.

J. Brien, B. Bennett, K. Nakatsu, 1986, The Journal of pharmacology and experimental therapeutics.

Mechanism of glyceryl trinitrate-induced vasodilation. I. Relationship between drug biotransformation, tissue cyclic GMP elevation and relaxation of rabbit aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 1988, The Journal of pharmacology and experimental therapeutics.

Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates.

J. Brien, K. Nakatsu, B. McLaughlin, 1989, Canadian journal of physiology and pharmacology.

Determination of Chromium (VI) and (III) by Adsorptive Stripping Voltammetry with Pyrocatechol Violet

D. Zoutman, G. Vanloon, K. Nakatsu, 1997 .

Heme oxygenase activity in fetal and adult sheep is not altered by acclimatization to high altitude hypoxia.

R. Kinobe, J. Brien, L. Longo, 2006, Canadian journal of physiology and pharmacology.

Perinatal iron deficiency combined with a high-fat diet causes obesity and cardiovascular dysregulation.

M. Adams, M. Komolova, K. Nakatsu, 2012, Endocrinology.

Identification of human hepatic cytochrome P450 sources of N-alkylprotoporphyrin IX after interaction with porphyrinogenic xenobiotics, implications for detection of xenobiotic-induced porphyria in humans.

K. Nakatsu, G. S. Marks, J. Lavigne, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Porphyrinogenic xenobiotic-induced N-alkylprotoporphyrin IX formation: a bioassay utilizing chick embryo hepatic ferrochelatase.

K. Nakatsu, G. S. Marks, J. T. Gamble, 2002, Journal of pharmacological and toxicological methods.

Drug-enhanced carbon monoxide production from heme by cytochrome P450 reductase

Z. Jia, K. Nakatsu, D. Vukomanovic, 2017, Medical gas research.

In vitro Activation of heme oxygenase-2 by menadione and its analogs

Z. Jia, J. Brien, K. Nakatsu, 2014, Medical gas research.

Does carbon monoxide play a role in cigarette smoke dependence?

L. Forkert, J. Brien, B. Milne, 2012 .

Release of hydroxyproline from rat hearts perfused with collagenase

J. Warr, K. Nakatsu, 1975, Experientia.

Glyceryl trinitrate-induced vasodilation is inhibited by ultraviolet irradiation despite enhanced nitric oxide generation: evidence for formation of a nitric oxide conjugate.

J. Brien, K. Nakatsu, B. McLaughlin, 1999, The Journal of pharmacology and experimental therapeutics.

Peroxynitrite-mediated inactivation of heme oxygenases

R. Kinobe, K. Nakatsu, Yanbin Ji, 2004, BMC pharmacology.

YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate.

J. Brien, K. Nakatsu, B. McLaughlin, 2001, Canadian journal of physiology and pharmacology.

Differential inhibition of rat and mouse microsome heme oxygenase by derivatives of imidazole and benzimidazole.

J. Vlahakis, K. Nakatsu, W. Szarek, 2017, Canadian journal of physiology and pharmacology.

The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate.

J. Brien, K. Nakatsu, G. S. Marks, 1997, Canadian journal of physiology and pharmacology.

Heme oxygenase activity in the adult rat aorta and liver as measured by carbon monoxide formation.

D K Stevenson, K Nakatsu, D. Stevenson, 1995, Canadian journal of physiology and pharmacology.

Riboflavin and pyrroloquinoline quinone generate carbon monoxide in the presence of tissue microsomes or recombinant human cytochrome P-450 oxidoreductase (CPR); implications for possible roles in gasotransmission.

Z. Jia, Graeme N. Smith, K. Nakatsu, 2019, Canadian journal of physiology and pharmacology.

Structure–Activity Relationships of 1,2‐Disubstituted Benzimidazoles: Selective Inhibition of Heme Oxygenase‐2 Activity

K. Nakatsu, W. Szarek, D. Vukomanovic, 2015, ChemMedChem.

Heme Oxygenase Inhibition by α‐(1H‐Imidazol‐1‐yl)‐ω‐phenylalkanes: Effect of Introduction of Heteroatoms in the Alkyl Linker

G. Roman, J. Vlahakis, K. Nakatsu, 2012, ChemMedChem.

Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition.

Z. Jia, G. Roman, J. Vlahakis, 2011, Journal of pharmacological and toxicological methods.

Acute depletion of heme by succinylacetone alters vascular responses but does not induce hypertension.

M. Adams, K. Nakatsu, J. Soong, 2008, Canadian journal of physiology and pharmacology.

The source of heme for vascular heme oxygenase II: de novo heme biosynthesis in rat aorta.

L. Bui, J. Brien, K. Nakatsu, 2004, Canadian journal of physiology and pharmacology.

Potentiation of carbon monoxide-induced relaxation of rat aorta by YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole].

J. Brien, K. Nakatsu, B. McLaughlin, 2000, Canadian journal of physiology and pharmacology.

Lack of evidence for the involvement of cytochrome P-450 or other hemoproteins in metabolic activation of glyceryl trinitrate in rabbit aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 1993, The Journal of pharmacology and experimental therapeutics.

Carbon monoxide does not inhibit glyceryl trinitrate biotransformation by or relaxation of aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 1992, European journal of pharmacology.

What role does the heme-- heme oxygenase--carbon monoxide system play in vasoregulation?

J. Brien, K. Nakatsu, G. S. Marks, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

Effectiveness of Novel Imidazole-Dioxolane Heme Oxygenase Inhibitors in Renal Proximal Tubule Epithelial Cells

R. Motterlini, R. Kinobe, J. Brien, 2007, Journal of Pharmacology and Experimental Therapeutics.

Inhibition of the action of nitric oxide prodrugs by pyocyanin: mechanistic studies.

J. Brien, D. Maurice, K. Nakatsu, 1997, Canadian journal of physiology and pharmacology.

Electrospray mass-spectrometric, spectrophotometric and electrochemical methods do not provide evidence for the binding of nitric oxide by pyocyanine at pH 7.

D. Zoutman, J. Brien, K. Nakatsu, 1997, The Biochemical journal.

In vitro cytochrome P450 monooxygenase and prostaglandin H-synthase mediated aflatoxin B1 biotransformation in guinea pig tissues: Effects of β-naphthoflavone treatment

T. Massey, K. Nakatsu, Ling Liu, 2005, Archives of Toxicology.

Heme Oxygenase Expression in Selected Regions of Term Human Placenta

C. Graham, Graeme N. Smith, J. Brien, 2003, Experimental biology and medicine.

Requirement for reduced, unliganded hemoprotein for the hemoglobin- and myoglobin-mediated biotransformation of glyceryl trinitrate.

J. Brien, B. Bennett, K. Nakatsu, 1986, The Journal of pharmacology and experimental therapeutics.

Carbon monoxide decreases perfusion pressure in isolated human placenta.

C. Graham, G. N. Smith, S. Bainbridge, 2002, Placenta.

Nitric oxide-induced vasodilation of organic nitrate-tolerant rabbit aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 1988, Canadian journal of physiology and pharmacology.

Lack of Hemodynamic Effects After Extended Heme Synthesis Inhibition by Succinylacetone in Rats

M. Adams, K. Nakatsu, S. Bourque, 2010, Journal of Pharmacology and Experimental Therapeutics.

Thiol agents separate nitric oxide formation from vasodilation induced by glyceryl trinitrate.

J. Brien, K. Nakatsu, G. S. Marks, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.

R. Kinobe, J. Brien, J. Vlahakis, 2006, Journal of medicinal chemistry.

Interaction of glyceryl trinitrate and sodium nitroprusside with bovine pulmonary vein homogenate and 10,000 x g supernatant: biotransformation and nitric oxide formation.

J. Brien, K. Nakatsu, B. McLaughlin, 1991, Canadian journal of physiology and pharmacology.

Erratum to: “A novel role for ezrin in breast cancer angio/lymphangiogenesis”

D. LeBrun, B. Elliott, S. Sengupta, 2014, Breast Cancer Research.

The source of heme for vascular heme oxygenase I: heme uptake in rat aorta.

Ann Smith, L. Bui, J. Brien, 2004, Canadian journal of physiology and pharmacology.

Signal Transduction Pathways Involved in CO-Induced Vasodilation: The Role of Cyclic GMP/SolubleG uanylyl Cyclase

J. Brien, K. Nakatsu, B. McLaughlin, 2001 .

Sequestration of Glyceryl Trinitrate (Nitroglycerin) by Cardiopulmonary Bypass Oxygenators

J. Brien, B. Milne, K. Nakatsu, 1991, Anesthesia and Analgesia.

A simple, less stressful rat restrainer

J. Owen, K. Nakatsu, R. Tasker, 1984, Experientia.

Anti-Plasmodium activity of imidazole-dioxolane compounds.

I. Crandall, R. Kinobe, J. Vlahakis, 2006, Bioorganic & medicinal chemistry letters.

Heme oxygenase activity and immunohistochemical localization in bovine pulmonary artery and vein.

D. Stevenson, J. Brien, K. Nakatsu, 1997, Journal of cardiovascular pharmacology.

Heme Oxygenase Inhibition by 1‐Aryl‐2‐(1H‐imidazol‐1‐yl/1H‐1,2,4‐triazol‐1‐yl)ethanones and Their Derivatives

G. Roman, J. Vlahakis, K. Nakatsu, 2010, ChemMedChem.

Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring.

Z. Jia, J. Vlahakis, K. Nakatsu, 2009, Bioorganic & medicinal chemistry.

Microscale synthesis of high specific activity 3H‐nitroglycerin

J. Kawamoto, K. Nakatsu, J. Brien, 1987 .

Adenosine inhibition of isolated rabbit ileum and antagonism by theophylline.

K. Nakatsu, A. Ally, 1976, The Journal of pharmacology and experimental therapeutics.

Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations.

D. Stevenson, J. Brien, D. Maurice, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Ontogeny of heme oxygenase activity in the hippocampus, frontal cerebral cortex, and cerebellum of the guinea pig.

D K Stevenson, K Nakatsu, D. Stevenson, 1996, Brain research. Developmental brain research.

Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function.

J. Brien, K. Nakatsu, G. S. Marks, 1993, Canadian journal of physiology and pharmacology.

The Physiological Role of Carbon Monoxide Derived from Heme Oxidation Catalyzed by Heme Oxygenase

J. Brien, K. Nakatsu, B. McLaughlin, 2001 .

Carbon monoxide formation in the guinea pig hippocampus: ontogeny and effect of in vitro ethanol exposure.

D. Stevenson, J. Brien, K. Nakatsu, 1997, Brain research. Developmental brain research.

Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.

R. Kinobe, J. Brien, J. Vlahakis, 2005, Bioorganic & medicinal chemistry letters.

Role of cGMP in relaxation of vascular and other smooth muscle.

K. Nakatsu, J. Diamond, 1989, Canadian journal of physiology and pharmacology.

Inhibitors of the heme oxygenase - carbon monoxide system: on the doorstep of the clinic?

R. Kinobe, K. Nakatsu, Ryan A. Dercho, 2008, Canadian journal of physiology and pharmacology.

Structural Insights into Azole-based Inhibitors of Heme Oxygenase-1: Development of Selective Compounds for Therapeutic Applications.

Z. Jia, J. Vlahakis, K. Nakatsu, 2019, Current Medicinal Chemistry.

Inhibition of the Enzymatic Activity of Heme Oxygenases by Azole-Based Antifungal Drugs

R. Kinobe, J. Brien, J. Vlahakis, 2006, Journal of Pharmacology and Experimental Therapeutics.

Heme oxygenase activity in placenta: direct dependence on oxygen availability.

C. Graham, Graeme N. Smith, J. Brien, 2002, American journal of physiology. Heart and circulatory physiology.

Determination of disopyramide and mono-N-desisopropyl-disopyramide in serum by gas-liquid chromatography with nitrogen-selective detection.

P. Armstrong, J. Brien, K. Nakatsu, 1983, Journal of pharmacological methods.

Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells.

C. Graham, G. N. Smith, J. Brien, 2003, American journal of physiology. Heart and circulatory physiology.

Adenylate metabolism and adenosine formation in the heart.

K. Nakatsu, G. Drummond, 1972, The American journal of physiology.

Evidence for two adenine derivative receptors in rat ileum which are not involved in the nonadrenergic, noncholinergic response.

R. Stewart, K. Nakatsu, V. Bartlett, 1979, Canadian journal of physiology and pharmacology.

A Novel, “Double-Clamp” Binding Mode for Human Heme Oxygenase-1 Inhibition

Z. Jia, J. Vlahakis, K. Nakatsu, 2012, PloS one.

The Effects of Azole-Based Heme Oxygenase Inhibitors on Rat Cytochromes P450 2E1 and 3A1/2 and Human Cytochromes P450 3A4 and 2D6

G. Roman, J. Vlahakis, K. Nakatsu, 2010, Journal of Pharmacology and Experimental Therapeutics.

Heme Oxygenase Inhibition by 2‐Oxy‐substituted 1‐Azolyl‐4‐phenylbutanes: Effect of Variation of the Azole Moiety. X‐Ray Crystal Structure of Human Heme Oxygenase‐1 in Complex with 4‐Phenyl‐1‐(1H‐1,2,4‐triazol‐1‐yl)‐2‐butanone †

Z. Jia, G. Roman, K. Nakatsu, 2010, Chemical biology & drug design.

Identification of an Escherichia coli O157:H7 heme oxygenase with tandem functional repeats.

Z. Jia, A. Matte, M. Cygler, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Sedentariness and increased visceral adiposity in adult perinatally iron-deficient rats

M. Adams, M. Komolova, K. Nakatsu, 2008, International Journal of Obesity.

Long-Term Circulatory Consequences of Perinatal Iron Deficiency in Male Wistar Rats

M. Adams, M. Komolova, K. Nakatsu, 2008, Hypertension.

SHORT COMMUNICATION Sedentariness and increased visceral adiposity in adult perinatally iron-deficient rats

M. Adams, M. Komolova, K. Nakatsu, 2008 .

A novel role for ezrin in breast cancer angio/lymphangiogenesis

B. Elliott, S. Sengupta, K. Nakatsu, 2014, Breast Cancer Research.

Adenylate deaminase. A method for its localization in skeletal muscle.

K. Nakatsu, 1975, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Action of coenzyme A on adenine derivative receptors in isolated tissues.

K. Jhamandas, K. Nakatsu, J. Downie, 1980, European journal of pharmacology.

Analysis of nanomolar S-nitrosothiol concentrations in physiological media.

K Nakatsu, D. Zoutman, J. Brien, 1998, Journal of pharmacological and toxicological methods.

Analysis of pyocyanin from Pseudomonas aeruginosa by adsorptive stripping voltammetry.

K Nakatsu, D. Zoutman, J. Brien, 1996, Journal of pharmacological and toxicological methods.

Morphine diesters. I. Synthesis and action on guinea pig ileum.

J. Owen, K. Jhamandas, K. Nakatsu, 1984, Canadian journal of physiology and pharmacology.

Diacetylmorphine (heroin) hydrolases in human blood.

J. Owen, K. Nakatsu, 1983, Canadian journal of physiology and pharmacology.

Factors affecting antibiotic decisions for upper respiratory tract infections I: A survey of family physicians

D. Zoutman, B. Ford, J. Cosby, 2008 .

Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds

Z. Jia, J. Vlahakis, K. Nakatsu, 2013, Journal of The Royal Society Interface.

Plasma disposition and hemo‐dynamic effects of a single oral dose of isosorbide dinitrate in human males and females

G. Savard, E. Toffelmire, H. Abdollah, 1992, Biopharmaceutics & drug disposition.

The effects of hypothermic and normothermic cardiopulmonary bypass on glyceryl trinitrate activity.

J. Brien, B. Milne, F. Cervenko, 1994, Anesthesia and analgesia.

Early Treatment of the Inflammatory Stage of COVID-19 and its rationale

N. Karrow, K. Nakatsu, O. Halgas, 2021 .

An extracellular source of heme can induce a significant heme oxygenase mediated relaxation in the rat aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 2002, Canadian journal of physiology and pharmacology.

Dose-dependency of theophylline clearance and protein binding.

P. Munt, R. Wigle, K. Nakatsu, 1981, Thorax.

Dose-dependency oftheophylline clearance andprotein binding

P. Munt, R. Wigle, K. Nakatsu, 1981 .

Sequestration of Glyceryl Cardiopulmonary Bypass Trinitrate (Nitroglycerin) by Oxygenators

J. Brien, B. Milne, K. Nakatsu, 2006 .

Assay of glyceryl trinitrate, isosorbide dinitrate, and their metabolites in plasma by large‐bore capillary column gas‐liquid chromatography

J. Mccans, J. Brien, B. Bennett, 1990, Biopharmaceutics & drug disposition.

Determination of isosorbide dinitrate biotransformation in various tissues of the rabbit by capillary column gas-liquid chromatography.

J. Brien, K. Nakatsu, G. S. Marks, 1987, Biopharmaceutics & drug disposition.

Resin hemoperfusion as treatment for theophylline-induced seizures.

J. Fleetham, P. Munt, R. Wigle, 1979, Chest.

Thiol agents potentiate glyceryl trinitrate mediated relaxation of rabbit taenia coli: evidence for thiol-dependent biotransformation.

J. Brien, K. Nakatsu, G. S. Marks, 1997, Canadian journal of physiology and pharmacology.

Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines.

F. Murad, H. Schröder, D. Leitman, 1989, The Journal of pharmacology and experimental therapeutics.

Time-dependent increase in nitric oxide formation concurrent with vasodilation induced by sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine but not by glyceryl trinitrate.

J. Brien, S. Jimmo, K. Nakatsu, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Mechanism of glyceryl trinitrate-induced vasodilation. II. Lack of evidence for specific binding of GTN to bovine pulmonary vein.

J. Brien, K. Nakatsu, G. S. Marks, 1988, The Journal of pharmacology and experimental therapeutics.

Theophylline reassessed.

P. Munt, K. Nakatsu, M. Bukowskyj, 1984, Annals of internal medicine.

Biotransformation of Glyceryl Trinitrate and Elevation of Cyclic GMP Precede Glyceryl Trinitrate‐Induced Vasodilation

J. Brien, K. Nakatsu, B. McLaughlin, 1990, Journal of cardiovascular pharmacology.

Spreadsheets, data handling and statistics.

J. Owen, K. Nakatsu, 1989, Trends in pharmacological sciences.

Selectivity of imidazole–dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms

R. Kinobe, J. Brien, J. Vlahakis, 2006, British journal of pharmacology.

Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells.

C. Graham, G. N. Smith, J. Brien, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

Relationship between tissue damage and heme oxygenase expression in chorionic villi of term human placenta.

S. Macdonald-Goodfellow, C. Graham, G. N. Smith, 2003, American journal of physiology. Heart and circulatory physiology.

Measurement of endogenous carbon monoxide formation in biological systems.

J. Brien, K. Nakatsu, B. McLaughlin, 2002, Antioxidants & redox signaling.

Endogenous carbon monoxide formation by chorionic villi of term human placenta.

D. Stevenson, C. Graham, G. N. Smith, 2001, Placenta.

Heme oxygenase activity in term human placenta.

C. Graham, G. N. Smith, J. Brien, 2000, Placenta.

Heme oxygenase and nitric oxide synthase in the placenta of the guinea-pig during gestation.

C. Graham, J. Brien, K. Nakatsu, 1998, Placenta.

Perinatal iron deficiency affects locomotor behavior and water maze performance in adult male and female rats.

J. Reynolds, M. Adams, K. Nakatsu, 2008, The Journal of nutrition.

Relaxation of Vascular Smooth Muscle by Organic Nitrates: Ideas and Hypotheses on a Still Unsolved Problem

J. Brien, B. Bennett, K. Nakatsu, 1986 .

A comparative study of glyceryl trinitrate biotransformation and glyceryl trinitrate induced relaxation in bovine pulmonary artery and vein.

J. Brien, K. Nakatsu, G. S. Marks, 1987, Canadian journal of physiology and pharmacology.

Biotransformation of glyceryl trinitrate to glyceryl dinitrate by human hemoglobin.

J. Brien, B. Bennett, K. Nakatsu, 1984, Canadian journal of physiology and pharmacology.

THEOPHYLLINE PHARMACOKINETICS AND RESPIRATORY INFECTIONS

J. Fleetham, P. Munt, K. Nakatsu, 1978, The Lancet.

Comparison of buprenorphine and meloxicam for postsurgical analgesia in rats: effects on body weight, locomotor activity, and hemodynamic parameters.

M. Adams, A. Winterborn, K. Nakatsu, 2010, Journal of the American Association for Laboratory Animal Science : JAALAS.

Chemiluminescence headspace-gas analysis for determination of nitric oxide formation in biological systems.

J. Brien, K. Nakatsu, B. McLaughlin, 1996, Methods in enzymology.

Heme oxygenase activity and acute and chronic ethanol exposure in the hippocampus, frontal cerebral cortex, and cerebellum of the near-term fetal guinea pig.

D. Stevenson, J. Brien, K. Nakatsu, 1997, Alcohol.

Theophylline-7-acetic acid: lack of absorption and therapeutic effectiveness.

P. Munt, J. Owen, K. Nakatsu, 1979, Thorax.

Disposition of intravenous theophylline‐7‐acetic acid in rabbits

J. Owen, K. Nakatsu, 1980, Biopharmaceutics & drug disposition.

The bronchodilator effect of caffeine in adult asthmatics.

K. Nakatsu, M. Bukowskyj, 2015, The American review of respiratory disease.

Gram quantity synthesis and chromatographic assessment of 3,3′,4,4′-tetrachlorobiphenyl

J. Brien, K. Nakatsu, G. S. Marks, 1982 .

Determination of in vivo carbon monoxide production in laboratory animals via exhaled air.

D. Stevenson, R. Wong, K. Nakatsu, 2006, Journal of pharmacological and toxicological methods.

Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position.

J. Vlahakis, K. Nakatsu, W. Szarek, 2013, Bioorganic & medicinal chemistry.

Selective activation of heme oxygenase-2 by menadione.

Z. Jia, J. Brien, K. Nakatsu, 2011, Canadian journal of physiology and pharmacology.

RAPID COMMUNICATION / COMMUNICATION RAPIDE

Z. Jia, J. Brien, K. Nakatsu, 2011 .

Theophylline clearance. Lack of effect of influenza vaccination and ascorbic acid.

P. Munt, R. Wigle, K. Nakatsu, 1984, The American review of respiratory disease.

A facile, reliable method for staining blood vessel endothelium.

J. Brien, K. Nakatsu, G. S. Marks, 1988, Journal of pharmacological methods.

Endothelium-dependent relaxation of rabbit aorta by acetylcholine requires ethylenediaminetetraacetic acid.

J. Brien, K. Nakatsu, G. S. Marks, 1986, Canadian journal of physiology and pharmacology.

Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors.

Z. Jia, G. Roman, J. Vlahakis, 2010, Journal of inorganic biochemistry.

Direct evidence for nitric oxide formation from glyceryl trinitrate during incubation with intact bovine pulmonary artery.

J. Brien, K. Nakatsu, B. McLaughlin, 1992, Canadian journal of physiology and pharmacology.

Suicidal destruction of cytochrome P-450 and reduction of ferrochelatase activity by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells.

K. Nakatsu, G. S. Marks, R. A. Whitney, 1985, Molecular Pharmacology.

Relative cataleptic potency of narcotic analgesics, including 3,6-dibutanoylmorphine and 6-monoacetylmorphine

K. Nakatsu, R. Tasker, Peter L. VanderVelden, 1984, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Assembly of an inexpensive tail flick analgesia meter.

B. Milne, J. Owen, K. Jhamandas, 1981, Journal of pharmacological methods.

Morphine diesters. II. Blood metabolism and analgesic activity in the rat.

J. Owen, K. Nakatsu, 1984, Canadian journal of physiology and pharmacology.

Recombinant truncated and microsomal heme oxygenase-1 and -2: differential sensitivity to inhibitors.

Z. Jia, R. Kinobe, J. Brien, 2010, Canadian journal of physiology and pharmacology.

Sulfhydryl involvement in nitric oxide sequestration and nitric oxide induced guanylyl cyclase activation in vascular smooth muscle.

J. Brien, K. Nakatsu, B. McLaughlin, 1995, Canadian journal of physiology and pharmacology.