W. Murray

发表

beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. Design, synthesis, and lead identification.

K. Rhodes, B. Lagu, R. Scannevin, 2008, Bioorganic & medicinal chemistry letters.

β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 2. Optimization of α-amino substituents

K. Rhodes, B. Lagu, R. Scannevin, 2008 .

Solid-phase synthesis of Nα-benzyl-Nα-cinnamyl lysine and glutamic acid derivatives

P. Connolly, S. K. Wetter, W. Murray, 2000 .

3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

S. Emanuel, R. H. Gruninger, R. Lin, 2005, Bioorganic & medicinal chemistry letters.

Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling.

Z. Sui, W. Murray, Fu‐An Kang, 2010, Chemical communications.

Novel heterocycles as selective α1-adrenergic receptor antagonists

L. Jolliffe, V. Pulito, W. Murray, 2000 .

Novel arylpiperazines as selective α 1 -adrenergic receptor antagonists

L. Jolliffe, V. Pulito, W. Murray, 2000 .

Arylpiperazine substituted heterocycles as Selective α1a adrenergic antagonists

L. Jolliffe, V. Pulito, G. Kuo, 2002 .

Novel thiophene derivatives for the treatment of benign prostatic hyperplasia.

L. Jolliffe, V. Pulito, W. Murray, 2002, Bioorganic & medicinal chemistry letters.

Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB1R Inverse Agonists.

M. Macielag, W. Murray, K. Demarest, 2020, ACS medicinal chemistry letters.

Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.

S. Emanuel, P. Connolly, L. Jolliffe, 2003, Journal of medicinal chemistry.

Novel Cycloalkene Indole Carbazole Alkaloids via the Ring Closing Metathesis Reaction.

William V. Murray, L. Wilson, W. Murray, 2008 .

Novel cycloalkene indole carbazole alkaloids via the ring closing metathesis reaction

L. Wilson, W. Murray, Cangming Yang, 2007 .

An Efficient and Scalable Synthesis of (2R,αS)-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol: A Potent CETP Inhibitor

Songfeng Lu, G. Kuo, W. Murray, 2010 .

1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2.

D. Ritchie, Z. Sui, W. Murray, 2000, Bioorganic & medicinal chemistry letters.

Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes.

Z. Sui, Xuqing Zhang, M. Macielag, 2017, ACS medicinal chemistry letters.

Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists.

Z. Sui, Xuqing Zhang, W. Murray, 2017, Bioorganic & medicinal chemistry letters.

Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB1R Inverse Agonists.

M. Macielag, W. Murray, K. Demarest, 2020, ACS medicinal chemistry letters.

Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.

Z. Sui, T. Koudriakova, W. Murray, 2018, Bioorganic & medicinal chemistry letters.

1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2.

D. Ritchie, Z. Sui, W. Murray, 2000, Bioorganic & medicinal chemistry letters.

The Regioselective Synthesis of Tepoxalin, 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-methylpropanamide and Related 1,5-Diarylpyrazole Anti-inflammatory Agents

W. Murray, M. Wachter, D. Barton, 1991 .

Novel 6-oxo-6-naphthylhexanoic acid derivatives with anti-inflammatory and 5-lipoxygenase inhibitory activity

D. Ritchie, W. Murray, M. Wachter, 1991 .

Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists.

Songfeng Lu, J. Lenhard, G. Kuo, 2007, Journal of medicinal chemistry.

Solid phase synthesis of highly substituted 2,4-dioxopiperidines

W. Chai, W. Murray, 1999 .

Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors.

F. Du, S. Lee, E. Grant, 2018, Bioorganic & medicinal chemistry letters.

Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes.

T. Kirchner, F. Du, Z. Sui, 2017, ACS medicinal chemistry letters.

Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists.

T. Kirchner, F. Du, Z. Sui, 2017, Bioorganic & medicinal chemistry letters.

Discovery of Orally E ffi cacious Tetrahydrobenzimidazoles as TGR 5 Agonists for Type 2 Diabetes

T. Kirchner, F. Du, Z. Sui, 2017 .

Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists.

W. Murray, M. Singer, Scott R Pollack, 2008, Bioorganic & medicinal chemistry letters.

Novel non-peptidic neuropeptide Y Y2 receptor antagonists.

P. Bonaventure, J. A. Jablonowski, W. Chai, 2004, Bioorganic & medicinal chemistry letters.

Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.

Xun Li, R. Russell, E. Sieber-McMaster, 2009, Bioorganic & medicinal chemistry letters.

Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.

G. Kuo, W. Murray, Jun Z. Xu, 2007, Bioorganic & medicinal chemistry letters.

1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.

S. Emanuel, C. Rugg, R. H. Gruninger, 2005, Journal of medicinal chemistry.

2,5-disubstituted 3,4-dihydro-2H-benzo[b][1,4]thiazepines as potent and selective V2 arginine vasopressin receptor antagonists.

Robert H. Chen, W. Murray, J. Gunnet, 2003, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of novel 7-azaindolyl-heteroaryl-maleimides as potent and selective glycogen synthase kinase-3β (GSK-3β) inhibitors

G. Kuo, B. Maryanoff, W. Murray, 2004 .

SOLID PHASE SYNTHESIS OF 3,4-DISUBSTITUTED-7-CARBAMOYL-1,2,3,4-TETRAHYDROQUINOXALIN-2-ONES

R. Rivero, W. Murray, Jung Lee, 1997 .

Interesting behavior of alpha,beta-unsaturated oximes in intramolecular [4 + 2] cycloaddition reactions.

W. Murray, David François, A. Maden, 2004, Organic letters.

Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.

S. Emanuel, R. H. Gruninger, Angel R. Fuentes-Pesquera, 2005, Journal of medicinal chemistry.

An intramolecular oxo Diels-Alder approach to 1-oxo-1,2,3,3a, 4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl esters

D. Sawicka, I. Turchi, W. Murray, 2003 .

Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.

S. Emanuel, R. H. Gruninger, Angel R. Fuentes-Pesquera, 2005, Journal of medicinal chemistry.

A concise synthesis of 7-chloro-2-methylsulfanyl-thiazolo[4,5-b]pyridine-6-carbonitrile, a versatile intermediate for substituted 6-cyanothiazolopyridines

P. Connolly, W. Murray, Sigmond G. Johnson, 2006 .

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.

R. Lin, Angel R. Fuentes-Pesquera, P. Connolly, 2009, Bioorganic & medicinal chemistry letters.

Efficient conversion of Biginelli 3,4-dihydropyrimidin-2(1H)-one to pyrimidines via PyBroP-mediated coupling.

W. Murray, Xiaobing Li, Fu‐An Kang, 2005, The Journal of organic chemistry.

An azomethine ylide approach to complex alkaloid-like heterocycles.

I. Turchi, W. Murray, David François, 2007, The Journal of organic chemistry.

Regio- and diastereoselective ring-opening of (S)-(−)-2-(trifluoromethyl)oxirane with chiral 2,5-disubstituted tetrahydroquinolines in hexafluoro-2-propanol

R. Russell, K. Sorgi, W. Murray, 2010 .

Synthesis of densely functionalized pyrrolidinone templates by an intramolecular oxo-Diels-Alder reaction

W. Murray, P. K. Mishra, S. Sun, 2002 .

Simplified staurosporine analogs as potent JAK3 inhibitors.

Xin Chen, Xin Chen, L. Wilson, 2007, Bioorganic & medicinal chemistry letters.

Pd-catalyzed direct arylation of tautomerizable heterocycles with aryl boronic acids via C-OH bond activation using phosphonium salts.

Z. Sui, W. Murray, Fu‐An Kang, 2008, Journal of the American Chemical Society.

A simple regioselective synthesis of ethyl 1,5-diarylpyrazole-3-carboxylates

W. Murray, M. Wachter, 1989 .

Microwave enabled external carboxymethyl substituents in the ring-closing metathesis

L. Wilson, W. Murray, Cangming Yang, 2003 .

Phosphonium Coupling in the Direct Bond Formations of Tautomerizable Heterocycles via C–OH Bond Activation†

Z. Sui, W. Murray, Fu‐An Kang, 2009 .

Microwave assisted ring-opening of epoxides with N-biaryl sulfonamides in the synthesis of matrix metalloproteinase-9 inhibitors

Shyh-Ming Yang, W. Murray, 2008 .

Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors.

Xin Chen, Yan Zhang, S. Emanuel, 2005, Journal of medicinal chemistry.

7-(4-Alkylidenylpiperidinyl)-quinolone bacterial topoisomerase inhibitors.

K. Bush, Shu-chen Lin, Steven D. Paget, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors.

C. Prouty, G. Kuo, W. Murray, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones.

G. Kuo, Shyh-Ming Yang, W. Murray, 2016, The Journal of organic chemistry.

Facile synthesis of α,α′ disubstituted N-hydroxypyrrolidines and N-hydroxypiperidines via double 1,4-addition of hydroxylamine

W. Murray, Frédéric C. Bargiggia, 2006 .

Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists.

P. Tannenbaum, Xin Chen, Nareshkumar Jain, 2009, Bioorganic & medicinal chemistry letters.

Cross-metathesis assisted by microwave irradiation.

W. Murray, Frédéric C. Bargiggia, 2005, The Journal of organic chemistry.

Preparative high-performance liquid chromatographic separation of fluorodeoxy sugars

G. Caldwell, W. Murray, M. Evangelisto, 1995 .

A facile synthesis of 2-(3-alkynyl-2,3-dihydrobenzofuran-3-yl)acetate

W. Murray, F. Song, G. David, 2015 .

Solid-Phase Suzuki Coupling for C−C Bond Formation

W. Murray, J. Guiles, Sigmond G. Johnson, 1996 .

Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3β (GSK-3β) inhibitors☆

Xin Chen, C. Prouty, M. P. Beavers, 2004 .

Design, synthesis and biological evaluation of pyridine-phenylpiperazines: a novel series of potent and selective alpha1a-adrenergic receptor antagonist.

L. Jolliffe, C. Prouty, V. Pulito, 2000, Bioorganic & medicinal chemistry.

Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses.

Xin Chen, Xin Chen, L. Wilson, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.

T. Kirchner, F. Du, S. Lee, 2018, Bioorganic & medicinal chemistry letters.

An Investigation of the Uroselective Properties of Four Novel α1a-Adrenergic Receptor Subtype-Selective Antagonists

L S Mulcahy, L. Jolliffe, A. Reitz, 2000 .

Synthesis and erythropoietin receptor binding affinities of N,N-disubstituted amino acids.

P. Connolly, S. K. Wetter, L. Jolliffe, 2000, Bioorganic & medicinal chemistry letters.

2,5-Diketopiperazines, new chiral auxiliaries for asymmetric Diels-Alder reactions

T. Le, W. Murray, J. Bussolari, 1997 .

The synthesis of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their ketolides

Stuart Hayden, E. Grant, D. Guiadeen, 2005 .

An Efficient Synthesis of 3-Substituted N-Glycoside Indoles Useful as Sodium-Dependent Glucose Transporter Inhibitors

R. Russell, W. Murray, S. Stefanick, 2012 .

Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists.

L. Jolliffe, V. Pulito, W. Murray, 2000, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structure-activity relationships of phthalimide-phenylpiperazines: a novel series of potent and selective alpha(1)(a)-adrenergic receptor antagonists.

L. Jolliffe, C. Prouty, V. Pulito, 2000, Journal of medicinal chemistry.

Substituted pyrrolidin-2-one biphenyltetrazoles as angiotensin II antagonists

D. Underwood, A. Gill, W. Murray, 1992 .

Substituted lactam biphenyltetrazoles as angiotensin II mediated antihypertensives

R. Falotico, A. Gill, W. Murray, 1994 .

A highly efficient synthesis of RWJ 47639: A novel, orally active angiotensin II receptor antagonist

J. Hsi, A. Gill, W. Murray, 1993 .

A Highly Efficient Synthesis of RWJ 47639 (V): A Novel, Orally Active Angiotensin II Receptor Antagonist.

J. Hsi, A. Gill, W. Murray, 1995 .

1,3- And 1,5-bisbiphenylyl substituted 3-metcaptotriazoles as angiotensin II receptor antagonists

D. Underwood, A. Gill, W. Murray, 1993 .

beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents.

K. Rhodes, B. Lagu, R. Scannevin, 2008, Bioorganic & medicinal chemistry letters.

The Synthesis of 3-[3-(4-chlorophenyl)-1-(4-methoxyphenyl) -5-pyrazolyl]-N-hydroxy-N-methylpropanamide a regioisomer of tepoxalin

W. Murray, 1993 .

6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity.

R. DesJarlais, Shuyuan Zhao, M. Macielag, 2018, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors α/δ dual agonists

William V. Murray, Ronald K. Russell, Zhang Yan, 2008 .

Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual agonists of peroxisome proliferator-activated receptors alpha and delta.

A. Gibbs, M. Reuman, R. Russell, 2007, Journal of medicinal chemistry.

Synthesis of 3‐(1,5‐diphenyl‐3‐pyrazolyl)aryl propanoates

W. Murray, M. Wachter, S. Hadden, 1990 .

Synthesis of 3‐(1,5‐Diphenyl‐3‐pyrazolyl)aryl Propanoates.

W. Murray, M. Wachter, S. Hadden, 1991 .

Dimethyl Sulfide–Chlorine

W. Murray, 2001 .

Process Development for Scale-Up of a Novel 3,5-Substituted Thiazolidine-2,4-dione Compound as a Potent Inhibitor for Estrogen-Related Receptor 1

Hui-Sheng Huang, R. Patch, M. Player, 2014 .

SOLID PHASE DIELS-ALDER REACTIONS OF AMINO ACID DERIVED TRIENES

W. Murray, Sengen Sun, 1999 .

Addition of Acrylamide to Amino Aldehydes to Generate Non-Baylis-Hillman Adducts. Formation of Novel N-Acylhemiaminals

W. Murray, K. Beers, P. McDonnell, 1998 .

Steroids. 2. Synthesis of C-18 functionalized steroids via the Smith-Hughes route.

D. Williams, W. Murray, S. Y. Wang, 1984, Journal of medicinal chemistry.

Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3 beta (GSK-3 beta) inhibitors.

Xin Chen, C. Prouty, M. P. Beavers, 2004, Bioorganic & Medicinal Chemistry.

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.

J. Lenhard, G. Kuo, T. Rano, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer protein inhibitor.

A. Gibbs, M. Connelly, G. Kuo, 2009, Journal of medicinal chemistry.

Novel 6-Oxo-6-naphthylhexanoic Acid Derivatives with Anti-Inflammatory and 5-Lipoxygenase Inhibitory Activity.

D. Ritchie, W. Murray, M. Wachter, 1991 .