A. Chiu

发表

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.

W. Price, J. Duncia, J. Santella, 1991, Journal of medicinal chemistry.

Losartan (DuP 753), An Orally Active Nonpeptide Angiotensin II Receptor Antagonist

P. Timmermans, J. Duncia, D. Christ, 1991 .

The ligand binding signatures of the rat AT1A, AT1B and the human AT1 receptors are essentially identical.

A. Chiu, C. Burton, P. Benfield, 1993, Biochemical and biophysical research communications.

Nonpeptide Angiotensin II Receptor Antagonists. IV. EXP6155 and EXP6803

P. Timmermans, W. Price, J. Duncia, 1989, Hypertension.

Formation of angiotensin III by angiotensin-converting enzyme.

J. Stewart, A. Chiu, J. Ryan, 1976, The Biochemical journal.

Synthesis and pharmacology of a prohormone angiotensin antagonist.

A. Day, A. Chiu, R. Freer, 1979, European journal of pharmacology.

DuP 753 can antagonize the effects of angiotensin II in rat liver.

A. Chiu, J. Garrison, P. Bauer, 1991, Molecular pharmacology.

Monoclonal antibodies to angiotensin II.

P. Timmermans, T. Reilly, A. Chiu, 1987, Biochemical and biophysical research communications.

Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research.

P. Timmermans, K. Catt, M. Peach, 1991, Hypertension.

Proposed update of angiotensin receptor nomenclature.

P. Timmermans, K. Catt, T. Goodfriend, 1995, Hypertension.

Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent.

P. Timmermans, W. Price, J. Duncia, 1990, The Journal of pharmacology and experimental therapeutics.

Nonpeptide Angiotensin II Receptor Antagonist: Losartan

R. Lee, J. Duncia, R. Wexler, 1993 .

Nonpeptide angiotensin II receptor antagonists.

P. Timmermans, W. Price, J. Duncia, 1990, American journal of hypertension.

The discovery of a new class of highly specific nonpeptide angiotensin II receptor antagonists.

P. Timmermans, W. Price, J. Duncia, 1991, American journal of hypertension.

Identification of angiotensin II receptor subtypes.

P. Timmermans, L. Pease, J. Duncia, 1989, Biochemical and biophysical research communications.

Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.

P. Timmermans, W. Price, J. Duncia, 1990, The Journal of pharmacology and experimental therapeutics.

Discrimination of angiotensin II receptor subtypes by dithiothreitol.

J. Duncia, R. Wexler, T. Nguyen, 1989, European journal of pharmacology.

AT1 receptors mediate the release of prostaglandins in porcine smooth muscle cells and rat astrocytes.

R. Chang, P. Timmermans, A. Chiu, 1992, American journal of hypertension.

[125I]EXP985: a highly potent and specific nonpeptide radioligand antagonist for the AT1 angiotensin receptor.

A. Chiu, W. Roscoe, D. E. McCall, 1992, Biochemical and biophysical research communications.

Nonpeptide angiotensin II receptor antagonists.

P. Timmermans, W. Price, J. Duncia, 1990, Trends in pharmacological sciences.

Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).

P. Timmermans, A. Chiu, P. Wong, 1990, The Journal of pharmacology and experimental therapeutics.

Nonpeptide Angiotensin II Receptor Antagonists: Studies With EXP9270 and DuP 753

P. Timmermans, W. Price, J. Duncia, 1990, Hypertension.

New perspectives in angiotensin system control.

P. Timmermans, A. Chiu, P. Wong, 1993, Journal of human hypertension.

Regional distribution of the two subtypes of angiotensin II receptor in rat brain using selective nonpeptide antagonists

P. Timmermans, A. Chiu, K. H. Leung, 1991, Neuroscience Letters.

Pharmacological characteristics of receptor-operated and potential-operated Ca2+ channels in rat aorta.

P. Timmermans, A. Chiu, D. E. McCall, 1986, European journal of pharmacology.

Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells.

P. Timmermans, A. Chiu, W. Roscoe, 1991, Receptor.

Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X.

P. Timmermans, W. Price, J. Duncia, 1990, Hypertension.

Non-peptide angiotensin II receptor antagonists. II. Pharmacology of S-8308.

P. Timmermans, W. Price, D. Carini, 1988, European journal of pharmacology.

Nonpeptide angiotensin II receptor antagonists. I. Pharmacological characterization of 2-n-butyl-4-chloro-1-(2-chlorobenzyl)imidazole-5-acetic acid, sodium salt (S-8307).

P. Timmermans, W. Price, D. Carini, 1988, The Journal of pharmacology and experimental therapeutics.

Monoclonal antibodies directed against basic fibroblast growth factor which inhibit its biological activity in vitro and in vivo.

P. Timmermans, D. W. Watson, T. Reilly, 1989, Biochemical and biophysical research communications.

In vitro pharmacology of DuP 753.

P. Timmermans, W. Price, J. Duncia, 1991, American journal of hypertension.

Nonpeptide angiotensin II receptor antagonists. IX. Antihypertensive activity in rats of DuP 753, an orally active antihypertensive agent.

P. Timmermans, W. Price, J. Duncia, 1990, The Journal of pharmacology and experimental therapeutics.

Pharmacology of nonpeptide angiotensin II receptor antagonists.

P. Timmermans, A. Chiu, P. Wong, 1992, Annual review of pharmacology and toxicology.

Characterization of angiotensin AT1A receptor isoform by its ligand binding signature

A. Chiu, P. Benfield, J. Dunscomb, 1993, Regulatory Peptides.

Defining Angiotensin Receptor Subtypes

P. Timmermans, A. Chiu, Ronald D. Smith, 1994 .

Angiotensin II receptor antagonists and receptor subtypes

P. Timmermans, J. Duncia, A. Chiu, 1992, Trends in Endocrinology & Metabolism.

Angiotensin II receptors and functional correlates.

P. Timmermans, A. Chiu, P. Wong, 1992, American journal of hypertension.

Balanced angiotensin II receptor antagonists. III. The effects of substitution at the imidazole 5-position.

P. Timmermans, J. Duncia, J. Santella, 1994 .

The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist

P. Timmermans, W. Price, J. Duncia, 1992, Medicinal research reviews.

Localization of angiotensin converting enzyme (kininase II). II. Immunocytochemistry and immunofluorescence.

U. Ryan, A. Chiu, J. Ryan, 1976, Tissue & cell.

Effects of recombinant plasminogen activator inhibitor type 1 on fibrinolysis in vitro and in vivo.

R. Knabb, T. Reilly, A. Chiu, 1990, Thrombosis research.

DuP 532: a second generation of nonpeptide angiotensin II receptor antagonists.

P. Timmermans, W. Price, J. Duncia, 1991, Biochemical and biophysical research communications.

Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent.

P. Timmermans, W. Price, J. Duncia, 1990, The Journal of pharmacology and experimental therapeutics.

Antihypertensive Activity of 2[(2-Hydroxyphenyl) amino] -4(3H)-quinazolinone

M. Hussain, P. Timmermans, W. Price, 1988, Pharmaceutical Research.

Nonpeptide angiotensin II receptor antagonists. III. Structure-function studies.

P. Timmermans, W. Price, J. Duncia, 1989, The Journal of pharmacology and experimental therapeutics.

The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists

P. Timmermans, R. Wexler, D. Carini, 1993 .

Angiotensin II receptors and angiotensin II receptor antagonists.

P. Timmermans, R. Wexler, D. Carini, 1993, Pharmacological reviews.

Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives.

P. Timmermans, W. Price, J. Duncia, 1990, Journal of medicinal chemistry.

The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives.

P. Timmermans, W. Price, J. Duncia, 1990, Journal of medicinal chemistry.

A sensitive radiochemical assay for angiotensin-converting enzyme (kinase II).

U. Ryan, A. Chiu, J. Ryan, 1975, The Biochemical journal.

Angiotensin II receptor subtypes.

R D Smith, P. Timmermans, P C Wong, 1992, American journal of hypertension.

Novel angiotensin receptor subtypes in fowl.

J. Keiser, A. Chiu, C. Patton, 1994, The American journal of physiology.

Ca++ utilization in the constriction of rat aorta to full and partial alpha-1 adrenoceptor agonists.

P. Timmermans, A. Chiu, M. Thoolen, 1986, The Journal of pharmacology and experimental therapeutics.

Balanced angiotensin II receptor antagonists. II.1,2 4-aminomethyl- and acylaminomethylimidazoles

P. Timmermans, R. Olson, R. Wexler, 1994 .

The influence of acidosis on the chronotropic effects of tyramine in guinea-pig atria: relation to tyramine uptake and metabolism.

M. Peach, A. Chiu, 1972, The Journal of pharmacology and experimental therapeutics.

Angiotensin II Receptor Antagonists From Discovery to Antihypertensive Drugs

P. Timmermans, W. Price, J. Duncia, 1991, Hypertension.

Kininase II (angiotensin converting enzyme) and endothelial cells in culture.

U. Ryan, A. Chiu, J. Ryan, 1976 .

Effect of calcium entry blockers on blood pressure and vasoconstrictor responses to alpha-1 adrenoceptor stimulation in conscious spontaneously hypertensive rats

P. Timmermans, A. Chiu, M. Thoolen, 1987, Cardiovascular Drugs and Therapy.

Monoclonal Antibodies to Tissue-Type Plasminogen Activator which Prolong its Clearance In Vivo

R. Knabb, T. Reilly, A. Chiu, 1989, Thrombosis and Haemostasis.

Characterization of biochemical responses of angiotensin II (AT2) binding sites in the rat pheochromocytoma PC12W cells.

P. Timmermans, A. Chiu, R. Smith, 1992, European journal of pharmacology.

[3H]DUP 753, a highly potent and specific radioligand for the angiotensin II-1 receptor subtype.

P. Timmermans, P. Aldrich, A. Chiu, 1990, Biochemical and biophysical research communications.

The preclinical basis of the therapeutic evaluation of losartan

P. Timmermans, A. Chiu, P. Wong, 1995, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

In vivo pharmacology of DuP 753.

P. Timmermans, W. Price, J. Duncia, 1991, American journal of hypertension.

Properties of angiotensin II receptors of domestic turkey (Meleagris gallopavo) adrenal steroidogenic cells.

P. McIlroy, A. Chiu, R. Carsia, 1994, General and comparative endocrinology.

Non-peptide angiotensin II receptor antagonist and angiotensin-convering enzyme inhibitor: effect on a renin-induced deficit of a passive avoidance response in rats

P. Timmermans, A. Chiu, V. Denoble, 1991, Brain Research.

High-level synthesis of biologically active human plasminogen activator inhibitor type 1 (PAI-1) in Escherichia coli.

G. Davis, T. Reilly, A. Chiu, 1990, Gene.

Calcium handling in vasoconstriction to stimulation of alpha 1- and alpha 2-adrenoceptors.

P. Timmermans, A. Chiu, M. Thoolen, 1987, Canadian Journal of Physiology and Pharmacology.

Ca++ utilization in the constriction of rat aorta to stimulation of protein kinase C by phorbol dibutyrate.

P. Timmermans, J. Bozarth, M. Forsythe, 1987, The Journal of pharmacology and experimental therapeutics.

Angiotensin-induced steroidogenesis in rabbit adrenal: effects of pH and calcium

A. Chiu, R. Freer, 1979, Molecular and Cellular Endocrinology.

Relationship between phosphatidylinositol turnover and Ca++ mobilization induced by alpha-1 adrenoceptor stimulation in the rat aorta.

P. Timmermans, J. Bozarth, A. Chiu, 1987, The Journal of pharmacology and experimental therapeutics.

Imidazolinones as nonpeptide angiotensin II receptor antagonists

P. Timmermans, R. Wexler, A. Chiu, 1994 .

Rationale for the chemical development of angiotensin II receptor antagonists.

P. Timmermans, J. Duncia, R. Wexler, 1992, American journal of hypertension.

Inhibition of the thrombin-platelet reactions by DuP 714.

S. Mousa, P. Timmermans, J. Bozarth, 1991, Biochemical and biophysical research communications.

Discovery of losartan, the first angiotensin II receptor antagonist.

P. Timmermans, J. Duncia, R. Wexler, 1995, Journal of human hypertension.

Angiotensin II exerts its effect on aldosterone production and potassium permeability through receptor subtype AT1 in rat adrenal glomerulosa cells.

G. Hajnóczky, A. Chiu, A. Spät, 1992, Biochemical Pharmacology.

Pharmacology and pharmacokinetics of a novel nonpeptide angiotensin II receptor antagonist--DMP 811.

P. Timmermans, W. Price, R. Wexler, 1995, Clinical and experimental hypertension.

Angiotensin II receptor heterogeneity.

L. Pease, J. Duncia, R. Wexler, 1991, American journal of hypertension.

Balanced angiotensin II receptor antagonists. I. The effects of biphenyl “ortho”-substitution on AT1/AT2 affinities

P. Timmermans, R. Olson, R. Wexler, 1994 .

EXP597, a nonpeptide angiotensin II receptor antagonist with high affinities for the angiotensin AT1 and AT2 receptor subtypes.

P. Timmermans, J. Duncia, J. Santella, 1994, European journal of pharmacology.

Pharmacology of DuP 532, a selective and noncompetitive AT1 receptor antagonist.

P. Timmermans, R. Wexler, D. Carini, 1991, The Journal of pharmacology and experimental therapeutics.

Nonpeptide angiotensin II receptor antagonists: a novel class of antihypertensive agents.

P. Timmermans, W. Price, J. Duncia, 1990, Blood vessels.

Angiotensin II receptor subtypes and their selective nonpeptide ligands.

P. Timmermans, J. Duncia, A. Chiu, 1990, Receptor.

EXP 6803, A Nonpeptide Angiotensin II Receptor Antagonist

P. Timmermans, W. Price, J. Duncia, 1989 .