M S Brown

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Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.

D. Russell, M. Brown, J. Goldstein, 1985, Annual review of cell biology.

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.

X. Chen, M. Brown, R. Prywes, 2000, Molecular cell.

Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis.

M. Brown, J. Goldstein, J L Goldstein, 1987, Circulation.

Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.

M. Brown, J. Goldstein, Michael S. Brown, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

R. Hammer, I. Shimomura, M. Brown, 1998, The Journal of clinical investigation.

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

D K Burns, D. Burns, M. Brown, 1994, The Journal of clinical investigation.

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.

R J Havel, R. Mahley, R. Havel, 1982, Journal of lipid research.

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

M. Nakanishi, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents.

M. Brown, J. Goldstein, Michael S. Brown, 1980, Journal of lipid research.

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

R. Hammer, I. Shimomura, M. Brown, 1997, The Journal of clinical investigation.

Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts.

M. Krieger, M. Brown, J. Goldstein, 1978, Proceedings of the National Academy of Sciences of the United States of America.

The LDL receptor locus and the genetics of familial hypercholesterolemia.

M. Brown, J. Goldstein, J L Goldstein, 1979, Annual review of genetics.

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins.

M. Brown, J. Goldstein, Michael S. Brown, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

B. Shan, J. Goldstein, Michael S. Brown, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

R. Hammer, I. Shimomura, M. Brown, 1997, The Journal of clinical investigation.

The clinical investigator: bewitched, bothered, and bewildered--but still beloved.

M. Brown, J. Goldstein, J L Goldstein, 1997, The Journal of clinical investigation.

The LDL receptor gene: a mosaic of exons shared with different proteins.

T. Südhof, D. Russell, M. Brown, 1985, Science.

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition.

M. Brown, J. Goldstein, Michael S. Brown, 1979, Proceedings of the National Academy of Sciences of the United States of America.

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.

M. Brown, J. Goldstein, Michael S. Brown, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

M. Brown, J. Goldstein, J L Goldstein, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Cellular Pathology of Progressive Atherosclerosis in the WHHL Rabbit: An Animal Model of Familial Hypercholesterolemia

T. Kita, J. Goldstein, Michael S. Brown, 1983, Arteriosclerosis.

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

I. Shimomura, M. Brown, H. Shimano, 1997, The Journal of clinical investigation.

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells.

A. Levinson, M. Brown, J. Goldstein, 1993, Science.

How LDL receptors influence cholesterol and atherosclerosis.

M. Brown, J. Goldstein, J L Goldstein, 1984, Scientific American.

Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells.

M. Krieger, A. Gotto, H. Pownall, 1979, Journal of supramolecular structure.

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.

S. Armstrong, T. Südhof, M. Brown, 1993, The Journal of biological chemistry.

Replacement of neutral lipids of low density lipoprotein with esters of long chain unsaturated fatty acids.

M. Krieger, M. Brown, J. Goldstein, 1979, The Journal of biological chemistry.

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

M. Brown, J. Goldstein, Michael S. Brown, 1980, The Journal of biological chemistry.

Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.

M. Brown, J. Goldstein, Michael S. Brown, 2009, Proceedings of the National Academy of Sciences of the United States of America.

Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching.

L Orci, L. Orci, M. Brown, 1978, Experimental cell research.

Receptor-mediated endocytosis of low-density lipoprotein in cultured cells.

M. Brown, J. Goldstein, Michael S. Brown, 1983, Methods in enzymology.

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1990, The Journal of biological chemistry.

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

S M Grundy, S. Grundy, D. Bilheimer, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Lowering plasma cholesterol by raising ldl receptors. 1981.

J. Goldstein, J L Goldstein, M S Brown, 2004, Atherosclerosis. Supplements.

Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

M. Brown, J. Goldstein, J L Goldstein, 1974, The Journal of biological chemistry.