Steven V Ley

发表

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Richard J Ingham, Claudio Battilocchio, Joel M Hawkins, 2014, Beilstein journal of organic chemistry.

The Engineering of Chemical Synthesis: Humans and Machines Working in Harmony.

Steven V Ley, S. Ley, 2018, Angewandte Chemie.

Callipeltosides A, B and C: Total Syntheses and Structural Confirmation

Richard A Booth, Steven V Ley, James R Frost, 2015, Chemistry.

Organic synthesis: march of the machines.

Richard J Ingham, Steven V Ley, Daniel E. Fitzpatrick, 2015, Angewandte Chemie.

Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server

Steven V Ley, Daniel E. Fitzpatrick, Daniel E Fitzpatrick, 2018, Angewandte Chemie.

Development of a web-based platform for studying lithiation reactions in silico.

Steven V Ley, Daniel E. Fitzpatrick, Biagia Musio, 2015, Chemical communications.

Camera-enabled techniques for organic synthesis

Richard J Ingham, Steven V Ley, Matthew O’Brien, 2013, Beilstein journal of organic chemistry.

Enabling Technologies for the Future of Chemical Synthesis

Claudio Battilocchio, Steven V Ley, Daniel E. Fitzpatrick, 2016, ACS central science.

Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor.

Steven V Ley, Anastasios Polyzos, S. Ley, 2015, Accounts of chemical research.

Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles.

Brian H Warrington, Steven V Ley, S. Ley, 2004, Journal of combinatorial chemistry.

Continuous multiple liquid-liquid separation: diazotization of amino acids in flow.

Steven V Ley, S. Ley, Matthew O'Brien, 2012, Organic letters.

Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations.

Steven V Ley, Ian R Baxendale, S. Ley, 2006, Chemistry.

Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide.

Claudio Battilocchio, Joel M Hawkins, Steven V Ley, 2014, Organic Letters.

A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1.

Claudio Battilocchio, Steven V Ley, Ian R Baxendale, 2013, Chemistry.

Development of a flow method for the hydroboration/oxidation of olefins.

Steven V Ley, José A. Souto, S. Ley, 2015, Organic & biomolecular chemistry.

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Steven V Ley, Ian R Baxendale, S. Ley, 2006, Chemical communications.

Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439.

Claudio Battilocchio, Steven V Ley, José A. Souto, 2015, Organic letters.

A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist.

Steven V Ley, Ian R Baxendale, S. Ley, 2010, Chemistry.

Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines.

Steven V Ley, Ian R Baxendale, S. Ley, 2004, Organic & biomolecular chemistry.

Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.

Steven V Ley, Marcus Baumann, Ian R Baxendale, 2006, Organic letters.

Microwave reactions under continuous flow conditions.

Steven V Ley, Ian R Baxendale, S. Ley, 2007, Combinatorial chemistry & high throughput screening.

Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (II) acetate and tetra-n-butylammonium salts.

Steven V Ley, Bushra Al-Duri, J. Seville, 2005, Chemical communications.

[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor.

Steven V Ley, Ian R Baxendale, S. Ley, 2007, Organic & biomolecular chemistry.

Flow chemistry syntheses of natural products.

Steven V Ley, Duncan L Browne, S. Ley, 2013, Chemical Society reviews.

A "catch-react-release" method for the flow synthesis of 2-aminopyrimidines and preparation of the Imatinib base.

Richard J Ingham, Steven V Ley, Ian R Baxendale, 2012, Organic letters.

Multi-step synthesis by using modular flow reactors: the preparation of yne--ones and their use in heterocycle synthesis.

Steven V Ley, Ian R Baxendale, S. Ley, 2010, Chemistry.

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration.

Steven V Ley, Anastasios Polyzos, Duncan L Browne, 2012, Organic & biomolecular chemistry.

A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.

Steven V Ley, Lucia Tamborini, Ian R Baxendale, 2008, Journal of combinatorial chemistry.

The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib.

Steven V Ley, Mark D. Hopkin, Ian R Baxendale, 2013, Organic & biomolecular chemistry.

Flow chemistry meets advanced functional materials.

Steven V Ley, Daniel E. Fitzpatrick, Daniel E Fitzpatrick, 2014, Chemistry.

The oxygen-mediated synthesis of 1,3-butadiynes in continuous flow: using Teflon AF-2400 to effect gas/liquid contact.

Steven V Ley, Anastasios Polyzos, Trond Ulven, 2012, ChemSusChem.

A prototype continuous-flow liquid-liquid extraction system using open-source technology.

Steven V Ley, Duncan L Browne, S. Ley, 2012, Organic & biomolecular chemistry.

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

Alessandro Palmieri, Steven V Ley, Anastasios Polyzos, 2009, Beilstein journal of organic chemistry.

KMnO(4)-Mediated oxidation as a continuous flow process.

Steven V Ley, Marcus Baumann, Ian R Baxendale, 2010, Organic letters.

Polyurea-encapsulated palladium(II) acetate: a robust and recyclable catalyst for use in conventional and supercritical media.

Steven V Ley, S. Ley, A. Holmes, 2002, Chemical communications.

Organic synthesis in a changing world.

Steven V Ley, Ian R Baxendale, S. Ley, 2002, Chemical record.

Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly.

Daiki Sakai, Steven V Ley, Heiko Lange, 2011, Chemistry.

Continuous flow reaction monitoring using an on-line miniature mass spectrometer.

Steven V Ley, Ian R Baxendale, Duncan L Browne, 2012, Rapid communications in mass spectrometry : RCM.

Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes.

Steven V Ley, Ian R Baxendale, S. Ley, 2005, Organic & biomolecular chemistry.

Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates.

Steven V Ley, Catherine F. Carter, Ian R Baxendale, 2009, Organic & biomolecular chemistry.

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor.

Steven V Ley, Julia Madrzak, Ian R Baxendale, 2010, Organic & biomolecular chemistry.

Cyclopropanation using flow-generated diazo compounds.

Richard J Ingham, Claudio Battilocchio, Joel M Hawkins, 2015, Organic & biomolecular chemistry.

Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines.

Steven V Ley, Ian R Baxendale, S. Ley, 2007, Organic & biomolecular chemistry.

Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions.

Steven V Ley, Marcus Baumann, Ian R Baxendale, 2008, Organic & biomolecular chemistry.

A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences**

Richard J Ingham, Claudio Battilocchio, Joel M Hawkins, 2014, Angewandte Chemie.

Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.

Steven V Ley, Ian R Baxendale, S. Ley, 2004, Chemistry.

Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods.

Steven V Ley, Rainer E. Martin, Rainer E Martin, 2011, ACS combinatorial science.

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.

Steven V Ley, Ian R Baxendale, S. Ley, 2010, Organic & biomolecular chemistry.

Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system.

Steven V Ley, Mark D. Hopkin, S. Ley, 2007, Journal of combinatorial chemistry.

The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines.

Steven V Ley, S. Ley, S. Saaby, 2005, Chemical communications.

A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures.

Steven V Ley, Marcus Baumann, Ian R Baxendale, 2011, Organic letters.

A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia.

Claudio Battilocchio, Joel M Hawkins, Steven V Ley, 2013, Organic letters.

A flow-based synthesis of imatinib: the API of Gleevec.

Steven V Ley, Mark D. Hopkin, Ian R Baxendale, 2010, Chemical communications.

Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles.

Steven V Ley, Ian R Baxendale, S. Ley, 2009, Angewandte Chemie.

Total synthesis of the amaryllidaceae alkaloid (+)-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions.

Steven V Ley, Ian R Baxendale, S. Ley, 2002, Angewandte Chemie.

Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst.

Steven V Ley, Filipe A Almeida Paz, Robert Raja, 2008, Chemistry.

A total synthesis of epothilones using solid-supported reagents and scavengers.

Steven V Ley, S. Ley, P. Jackson, 2003, Angewandte Chemie.

Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst.

Claudio Battilocchio, Joel M Hawkins, Steven V Ley, 2013, Organic letters.

On being green: can flow chemistry help?

Steven V Ley, S. Ley, 2012, Chemical record.

Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.

Steven V Ley, S. Ley, Hai‐Chen Wu, 2003, Chemical communications.

Accelerating spirocyclic polyketide synthesis using flow chemistry.

Steven V Ley, Colin M Pearson, Heiko Lange, 2014, Angewandte Chemie.

The continuous-flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor.

Steven V Ley, Anastasios Polyzos, Ian R Baxendale, 2011, Angewandte Chemie.

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods.

Steven V Ley, Mark D. Hopkin, Ian R Baxendale, 2013, Organic & biomolecular chemistry.

Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor.

Steven V Ley, Ian R Baxendale, S. Ley, 2011, Organic letters.

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles.

Steven V Ley, Heiko Lange, Ian R Baxendale, 2011, Organic & biomolecular chemistry.

A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds**

Claudio Battilocchio, Joel M Hawkins, Steven V Ley, 2015, Angewandte Chemie.

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Steven V Ley, Anastasios Polyzos, Heiko Lange, 2011, Beilstein journal of organic chemistry.

Fragment-based hit identification: thinking in 3D.

Nathan Brown, Steven V Ley, Kristian Birchall, 2013, Drug discovery today.

Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating.

Steven V Ley, Ian R Baxendale, S. Ley, 2005, Journal of combinatorial chemistry.

Encapsulation of palladium in polyurea microcapsules.

Steven V Ley, S. Ley, I. Shirley, 2002, Chemical communications.

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns.

Steven V Ley, Andreas Kirschning, Jan Hartwig, 2014, Organic & biomolecular chemistry.

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent.

Steven V Ley, Ian R Baxendale, S. Ley, 2011, Organic & biomolecular chemistry.