Marie-France Langelier

Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.

Alan Ashworth, Bhargav A. Patel, A. Ashworth, 2019, Journal of medicinal chemistry.

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Jamin D Steffen, C. Yeo, J. Pascal, 2014, Cancer research.

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.

Jamin D Steffen, B. E. Black, J. Pascal, 2015, Molecular cell.

The RPB2 Flap Loop of Human RNA Polymerase II Is Dispensable for Transcription Initiation and Elongation

Benoit Coulombe, Robert Landick, B. Coulombe, 2011, Molecular and Cellular Biology.

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

B. E. Black, J. Pascal, Marie-France Langelier, 2018, Nature Communications.