J. Brian Houston

发表

The Use of Biokinetics and in Vitro Methods in Toxicological Risk Evaluation

Gunnar Johanson, John M. Frazier, Christoph A. Reinhardt, 1996 .

Simultaneous Assessment of Uptake and Metabolism in Rat Hepatocytes: A Comprehensive Mechanistic Model

Aleksandra Galetin, A. Galetin, J. Houston, 2012, Journal of Pharmacology and Experimental Therapeutics.

Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir

J. Houston, J. Brian Houston, Alison J. Parker, 2008, Drug Metabolism and Disposition.

Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches

Kiyomi Ito, Kiyomi Ito, J. Houston, 2004, Pharmaceutical Research.

Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs

Ugo Zanelli, J. Houston, D. Hallifax, 2012, Drug Metabolism and Disposition.

Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential

Malcolm Rowland, Michael Gertz, Aleksandra Galetin, 2012, Pharmaceutical Research.

Uptake and Intracellular Binding of Lipophilic Amine Drugs by Isolated Rat Hepatocytes and Implications for Prediction of in Vivo Metabolic Clearance

J. Houston, D. Hallifax, David Hallifax, 2006, Drug Metabolism and Disposition.

Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data

Hugh A. Barton, Aleksandra Galetin, Yurong Lai, 2012, Drug Metabolism and Disposition.

Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes

Kiyomi Ito, Kiyomi Ito, J. Houston, 2004, Pharmaceutical Research.

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

Aleksandra Galetin, A. Galetin, J. Houston, 2009, Drug Metabolism and Disposition.

Multiple Inhibition Mechanisms and Prediction of Drug–Drug Interactions: Status of Metabolism and Transporter Models as Exemplified by Gemfibrozil–Drug Interactions

Aleksandra Galetin, A. Galetin, J. Houston, 2008, Pharmaceutical Research.

Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk

Nikolaos Tsamandouras, Michael Gertz, Aleksandra Galetin, 2014, Pharmaceutical Research.

PREDICTION OF METABOLIC CLEARANCE USING CRYOPRESERVED HUMAN HEPATOCYTES: KINETIC CHARACTERISTICS FOR FIVE BENZODIAZEPINES

J. Houston, D. Hallifax, N. Hakooz, 2005, Drug Metabolism and Disposition.

Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions

Claire Strain-Damerell, J. Houston, P. Nicklin, 2009, Drug Metabolism and Disposition.

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

A. D. Rodrigues, A. David Rodrigues, Manthena V. S. Varma, 2018, Drug Metabolism and Disposition.

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

Aleksandra Galetin, A. Galetin, J. Houston, 2011, Drug Metabolism and Disposition.

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

J. Houston, D. Hallifax, David Hallifax, 2010, Pharmaceutical Research.