C. Alonso

发表

Novel concepts in the development of platinum antitumor drugs.

J. Perez, M. Fuertes, J. Castilla, 2002, Current medicinal chemistry. Anti-cancer agents.

A cycloplatinated compound of p-isopropylbenzaldehyde thiosemicarbazone and its chloro-bridged derivative induce apoptosis in cis-DDP resistant cells which overexpress the H-ras oncogene.

J. Perez, C. Alonso, A. Quiroga, 1999, Journal of inorganic biochemistry.

DNA interaction and antitumor activity of a Pt(III) derivative of 2-mercaptopyridine.

V. Moreno, J. Perez, M. Prieto, 1999, Journal of inorganic biochemistry.

Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.

M. Fuertes, J. Pérez, P. Nguewa, 2005, Progress in biophysics and molecular biology.

In vitro antitumour activity of two isomeric cyclopalladiated compounds derived from benzoylbenzylidenimines

C. Alonso, C. Navarro-Ranninger, I. López‐Solera, 1993 .

Molecular Mechanisms for the B‐Z Transition in the Example of Poly[d(G—C)×d(G—C)] Polymers. A Critical Review

M. Fuertes, V. Cepeda, C. Alonso, 2006 .

Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors in cancer chemotherapy.

M. Fuertes, C. Quevedo, V. Cepeda, 2006, Recent patents on anti-cancer drug discovery.

Pharmacological modulation of Poly(ADP-ribose) polymerase-mediated cell death: exploitation in cancer chemotherapy.

M. Fuertes, P. Nguewa, C. Alonso, 2003, Molecular pharmacology.

Antitumor and cellular pharmacological properties of a novel platinum(IV) complex: trans-[PtCl(2)(OH)(2)(dimethylamine) (isopropylamine)].

L. Kèlland, M. Fuertes, C. Alonso, 2003, Molecular pharmacology.

Structural and Functional Analysis of 29 p16.7C Dimerization Mutants IDENTIFICATIONOFANOVELAROMATICCAGEDIMERIZATIONMOTIF

M. Salas, W. Meijer, M. Fuertes, 2007 .

Current status of the development of trans-platinum antitumor drugs.

J. Perez, M. Fuertes, C. Alonso, 2000, Critical reviews in oncology/hematology.

Induction of apoptosis by the bis-Pt(III) complex [Pt(2)(2-mercaptopyrimidine)(4)Cl(2)].

V. Moreno, J. Perez, M. Fuertes, 2000, Biochemical pharmacology.

Novel tetranuclear orthometalated complexes of Pd(II) and Pt(II) derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cell lines. Interaction of these complexes with DNA.

J. Perez, C. Alonso, A. Quiroga, 1998, Journal of medicinal chemistry.

Synthesis, characterization and DNA modification induced by a novel Pt(IV)-bis(monoglutarate) complex which induces apoptosis in glioma cells.

L. Kèlland, J. Perez, C. Alonso, 1999, Chemico-biological interactions.

Synthesis, crystal structure, and biological activity of a Pt-dipyridamole salt.

J. Perez, M. Monge, C. Alonso, 1994, Journal of inorganic biochemistry.

Palladium (II) compounds of putrescine and spermine. Synthesis, characterization, and DNA-binding and antitumor properties.

J. Perez, F. Zamora, C. Alonso, 1993, Journal of inorganic biochemistry.

Programmed cell death in trypanosomatids: a way to maximize their biological fitness?

M. Fuertes, P. Nguewa, C. Alonso, 2004, Trends in parasitology.

Apoptosis induction and inhibition of H-ras overexpression by novel trans-[PtCl2(isopropylamine)(amine')] complexes.

J. Perez, C. Alonso, E. I. Montero, 1999, Journal of inorganic biochemistry.

Synthesis and characterization of complexes of p-isopropyl benzaldehyde and methyl 2-pyridyl ketone thiosemicarbazones with Zn(II) and Cd(II) metallic centers. Cytotoxic activity and induction of apoptosis in Pam-ras cells.

J. Perez, C. Alonso, P. Souza, 1999, Journal of inorganic biochemistry.

Synthesis and characterization of Pd(II) and Pt(II) complexes of p-isopropylbenzaldehyde N-protected thiosemicarbazones. Cytotoxic activity against ras-transformed cells.

J. Perez, C. Alonso, A. Quiroga, 1999, Journal of inorganic biochemistry.

Biochemical modulation of Cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance.

M. Fuertes, C. Alonso, J. Pérez, 2003, Chemical reviews.

DNA binding and in vitro antileukemic activity of dimeric and tetrameric platinated complexes derived from p-isopropylbenzaldehyde thiosemicarbazone

C. Alonso, A. Quiroga, J. Pérez, 1998 .

Palladated and platinated complexes derived from phenylacetaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cells. Formation of DNA interstrand cross-links by these complexes.

J. Perez, C. Alonso, A. Quiroga, 1998, Journal of inorganic biochemistry.

Preparation and characterization of novel trans-[PtCl(2)(amine)(isopropylamine)] compounds: cytotoxic activity and apoptosis induction in ras-transformed cells.

J. Perez, C. Alonso, E. I. Montero, 1999, Journal of medicinal chemistry.

Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance

M. Fuertes, C. Alonso, J. Pérez, 2003 .

Biochemical mechanisms of cisplatin cytotoxicity.

Celia Quevedo, M. Fuertes, C. Quevedo, 2007, Anti-cancer agents in medicinal chemistry.

Binuclear chloro-bridged palladated and platinated complexes derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxicity against cisplatin resistant tumor cell lines.

J. Perez, C. Alonso, A. Quiroga, 1998, Journal of inorganic biochemistry.

Analysis of two cycloplatinated compounds derived from N-(4-methoxyphenyl)-alpha-benzoylbenzylidenamine. Comparison of the activity of these compounds with other isostructural cyclopalladated compounds.

J. Perez, C. Alonso, P. Raithby, 1993, Journal of medicinal chemistry.

CYCLOMETALATED COMPLEXES OF PLATINUM AND PALLADIUM WITH N-(4-CHLOROPHENYL)-ALPHA -BENZOYLBENZYLIDENEAMINE. IN VITRO CYTOSTATIC ACTIVITY, DNA MODIFICAT ION, AND INTERSTRAND CROSS-LINK STUDIES

Avelino Martín, C. Alonso, P. Raithby, 1996 .

X-Ray structure of cytotoxic trans-[PtCl(2)(dimethylamine)(isopropylamine)]: interstrand cross-link efficiency, DNA sequence specificity, and inhibition of the B-Z transition.

J. Perez, M. Fuertes, C. Alonso, 2000, Journal of medicinal chemistry.

Modification of the recognition of restriction sites of plasmid DNA by the antitumor drug Pt-pentamidine.

J. Perez, M. Fuertes, C. Alonso, 1996, Biochemical pharmacology.

DNA Interstrand Cross‐Linking Efficiency and Cytotoxic Activity of Novel Cadmium(II)–Thiocarbodiazone Complexes

C. Alonso, P. Souza, A. Matesanz, 2001, Chembiochem : a European journal of chemical biology.

Combined effect of platination and intercalation upon DNA binding of novel cytotoxic Pt-bis(naphthalimide) complexes.

S. Robinson, J. Perez, M. Braña, 1999, Journal of medicinal chemistry.

Cis-Dichloro(diaminosuccinate diethyl ester)palladium (II) as Pd(II)/Pt(II) model compound for DNA-binding and antitumor properties: solution equilibria of their aqua-, hydroxo-, and/or chloro-species.

J. Perez, C. Alonso, J. Niclós-Gutiérrez, 1996, Journal of inorganic biochemistry.

Cytotoxicity, DNA binding, and reactivity against nucleosides of platinum (II) and (IV) spermine compounds.

J. Perez, C. Alonso, P. Amo‐Ochoa, 1996, Journal of inorganic biochemistry.

Platinum (II) and (IV) spermidine complexes. Synthesis, characterization, and biological studies.

J. Perez, C. Alonso, V. González, 1994, Journal of inorganic biochemistry.

Molecular mechanisms for the B-Z transition in the example of poly[d(G-C) x d(G-C)] polymers. A critical review.

M. Fuertes, V. Cepeda, C. Alonso, 2006, Chemical reviews.

The berenil ligand directs the DNA binding of the cytotoxic drug Pt-berenil.

J. Perez, C. Alonso, V. González, 1997, Journal of inorganic biochemistry.

Synthesis, characterization, and DNA modification induced by a novel Pt-berenil compound with cytotoxic activity.

J. Perez, M. Fuertes, C. Alonso, 1996, Journal of inorganic biochemistry.

DNA binding properties and antileukemic (L1210) activity of a Pt-pentamidine complex.

J. M. Requena, D. Craciunescu, J. Perez, 1991, Chemico-Biological Interactions.

Quantification of Pt bound to DNA using total-reflection X-ray fluorescence (TXRF)

C. Alonso, V. González, J. Tornero, 1999 .

Binding of Pt-pentamidine to nucleosomal DNA. Studies of the antiproliferative activity of the drug against human cancer cells.

J. M. Requena, D. Craciunescu, J. Perez, 1993, Chemico-biological interactions.

Platinum complexes of p- and m-aminobenzamidine. Synthesis, characterization, and cytotoxic activity.

J. Perez, C. Alonso, J. R. Masaguer, 1992, Journal of inorganic biochemistry.

Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways.

J. Perez, M. Fuertes, M A Fuertes, 2003, Current medicinal chemistry.

Apoptosis Induction and DNA Interstrand Cross‐Link Formation by Cytotoxic trans‐[PtCl2(NH(CH3)2)(NHCH(CH3)2)]: Cross‐Linking between d(G) and Complementary d(C) within Oligonucleotide Duplexes

M. Fuertes, M. Leng, C. Alonso, 2002, Chembiochem : a European journal of chemical biology.

The formation of DNA interstrand cross-links by a novel bis-[Pt2Cl4(diminazene aceturate)2]Cl4.4H2O complex inhibits the B to Z transition.

J. Perez, M. Fuertes, C. Alonso, 1999, Molecular pharmacology.

Kinetics of the salt-induced B- to Z-DNA transition

M. Fuertes, C. Alonso, V. González, 1998, European Biophysics Journal.

The Formation of DNA Interstrand Cross-Links by a Novel Bis-[ Pt 2 Cl 4 ( diminazene aceturate ) 2 ] Cl 4 z 4 H 2 O Complex Inhibits the B to Z Transition

M. Fuertes, C. Alonso, A. Jiménez-Ruiz, 1999 .

Palladium(II) salt and complexes of spermidine with a six-member chelate ring. Synthesis, characterization, and initial DNA-binding and antitumor studies.

J. Perez, F. Zamora, C. Alonso, 1992, Journal of inorganic biochemistry.

Cellular Uptake, DNA Binding and Apoptosis Induction of Cytotoxic Trans-[PtCl2(N,N-dimethylamine)(Isopropylamine)] in A2780cisR Ovarian Tumor Cells

M. Fuertes, C. Alonso, A. Quiroga, 2001, Metal-based drugs.

Is cisplatin-induced cell death always produced by apoptosis?

José Perez, J. Perez, M. Fuertes, 2001, Molecular pharmacology.

Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells.

M. Fuertes, C. Quevedo, P. Nguewa, 2006, Medicinal chemistry (Shariqah (United Arab Emirates)).

Programmed Cell Death in Protozoa: An Evolutionary Point of View. The Example of Kinetoplastid Parasites

M. Fuertes, P. Nguewa, J. Castilla, 2008 .

Structural and functional analysis of phi29 p16.7C dimerization mutants: identification of a novel aromatic cage dimerization motif.

G. Rivas, D. Muñoz-Espín, M. Salas, 2007, The Journal of biological chemistry.

Determination of catalase activity in samples treated with [ZnCl2(isopropylamine)2]: a novel zinc complex that slows down the decay in activity of catalase extracts

J. García-Cañadas, M. Fuertes, C. Alonso, 2002 .

Anticancer compounds as leishmanicidal drugs: challenges in chemotherapy and future perspectives.

M. Fuertes, P. Nguewa, J. Castilla, 2008, Current medicinal chemistry.

Sterically hindered cisplatin derivatives with multiple carboxylate auxiliary arms: synthesis and reactions with guanosine-5'-monophosphate and plasmid DNA.

J. Perez, J. Reedijk, C. Alonso, 2001, Journal of inorganic biochemistry.

cis-dichloro-palladium(II) complexes with diaminosuccinic acid and its diethyl ester: synthesis, molecular structure, and preliminary DNA-binding and antitumor studies.

J. Perez, N. Dung, C. Alonso, 1994, Journal of inorganic biochemistry.

Novel Concepts in the Development of Platinum Antitumour Drugs: An Update

M. Fuertes, P. Nguewa, J. Castilla, 2004 .

Structural and Functional Analysis of φ29 p16.7C Dimerization Mutants

G. Rivas, D. Muñoz-Espín, M. Salas, 2007, Journal of Biological Chemistry.

Novel transplatinum(II) complexes with [N2O2] donor sets. Cellular pharmacology and apoptosis induction in Pam 212-ras cells.

N. Farrell, C. Alonso, A. Quiroga, 2006, Journal of medicinal chemistry.

cis-Dichloro(alpha,omega-diamino carboxylate ethyl ester)palladium(II) as Palladium(II) versus Platinum(II) Model Anticancer Drugs: Synthesis, Solution Equilibria of Their Aqua, Hydroxo, and/or Chloro Species, and in Vitro/in Vivo DNA-Binding Properties.

C. Alonso, M. Fernández, M. C. López, 1997, Inorganic chemistry.