X. Lei

发表

MiR-195 regulates cell apoptosis of human hepatocellular carcinoma cells by targeting LATS2.

Jia Yu, Xiaoyan Yang, Jie Yin, 2012, Die Pharmazie.

Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5′-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells*

C. Chalfant, Margaret A. Park, D. Wijesinghe, 2015, The Journal of Biological Chemistry.

Metabolic Effects of Selective Deletion of Group VIA Phospholipase A2 from Macrophages or Pancreatic Islet Beta-Cells

Haowei Song, J. Turk, X. Lei, 2020, Biomolecules.

Anti-chronic myeloid leukemia activity and quantitative structure-activity relationship of novel thiazole aminobenzamide derivatives.

Yuan Zhang, Xuan Cao, Yao-Wang Li, 2021, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of antitumour activity in vitro and in vivo of chrysin salicylate derivatives

Yunmei Liu, Xuan Cao, X. Lei, 2018, Natural product research.

A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy.

Xuan Cao, X. Lei, Guotao Tang, 2019, Colloids and surfaces. B, Biointerfaces.

Involvement of miR-133a and miR-326 in ADM resistance of HepG2 through modulating expression of ABCC1

Jia Yu, Xiaoyan Yang, Jie Yin, 2015, Journal of drug targeting.

Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita / Ins 2-derived-cells

S. Barnes, K. Mitra, Jianhua Zhang, 2013 .

Group VIA Ca 2þ -independent phospholipase A2 (iPLA2b) and its role in b-cell programmed cell death

X. Lei, S. Ramanadham, S. Barbour, 2010 .

A link between endoplasmic reticulum stress‐induced β‐cell apoptosis and the group VIA Ca2+‐independent phospholipase A2 (iPLA2β)

S. Zhang, X. Lei, S. Ramanadham, 2010, Diabetes, obesity & metabolism.

A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca 2+ -independent

X. Lei, S. Ramanadham, S. Barbour, 2010 .

Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.

X. Lei, S. Ramanadham, S. Barbour, 2010, Biochimie.

THE GROUP VIA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 (iPLA2β) PARTICIPATES IN ER STRESS-INDUCED INS-1 INSULINOMA CELL APOPTOSIS BY PROMOTING CERAMIDE GENERATION VIA HYDROLYSIS OF SPHINGOMYELINS BY

A. Bohrer, X. Lei, Shunzhong S Bao, 2008 .

The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.

Haowei Song, A. Bohrer, X. Lei, 2007, Biochemistry.

Attenuated Free Cholesterol Loading-induced Apoptosis but Preserved Phospholipid Composition of Peritoneal Macrophages from Mice That Do Not Express Group VIA Phospholipase A2*

J. Turk, C. Semenkovich, Yankun Li, 2007, Journal of Biological Chemistry.

Evidence for Proteolytic Processing and Stimulated Organelle Redistribution of iPLA2β

Shenmin Zhang, Haowei Song, J. Turk, 2010 .

Evidence for proteolytic processing and stimulated organelle redistribution of iPLA(2)beta.

S. Zhang, Haowei Song, J. Turk, 2010, Biochimica et biophysica acta.

Lipid mediators and biomarkers associated with type 1 diabetes development

Alexander J. Nelson, C. Mathews, M. Hessner, 2020, JCI insight.

Matthew J. Silva, K. Yarasheski, B. Christiansen, 2008, The American journal of pathology.

Matthew J. Silva, K. Yarasheski, B. Christiansen, 2008 .

iPLA2β and its role in male fertility, neurological disorders, metabolic disorders, and inflammation.

Alexander J. Nelson, J. Turk, X. Lei, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling

R. Mirmira, E. A. Phelps, E. Nakayasu, 2022, Molecular metabolism.

Therapeutic activity of DCC‐2036, a novel tyrosine kinase inhibitor, against triple‐negative breast cancer patient‐derived xenografts by targeting AXL/MET

Wei Zhang, Xiguang Chen, Jing Zhong, 2018, International journal of cancer.

Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis.

S. Zhang, A. Bohrer, X. Lei, 2012, American journal of physiology. Endocrinology and metabolism.

Ca2+-Independent Phospholipase A2β-Derived PGE2 Contributes to Osteogenesis.

G. Clines, X. Lei, S. Ramanadham, 2021, Prostaglandins & other lipid mediators.

HIV-protease inhibitors suppress skeletal muscle fatty acid oxidation by reducing CD36 and CPT1 fatty acid transporters.

K. Yarasheski, S. Zhang, X. Lei, 2010, Biochimica et biophysica acta.

Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA2β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes

C. Chalfant, X. Lei, S. Ramanadham, 2021, Molecules.

Spontaneous development of ER stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 (iPLA2beta) expression: A role for regulation by SREBP-1

F. R. Papa, S. Zhang, A. Bohrer, 2009 .

LINC01234 Accelerates the Progression of Breast Cancer via the miR-525-5p/Cold Shock Domain-Containing E1 Axis

Jia Yu, Rongfang He, Xiaoyan Yang, 2022, Disease markers.

Synthesis of new 7-O-modified chrysin derivatives and their anti-proliferative and apoptotic effects on human gastric carcinoma MGC-803 cells

Jun He, Yunmei Liu, X. Lei, 2014, Chemical Research in Chinese Universities.

Applications of "linkers" in fragment-based drug design.

Yuan Zhang, Xuan Cao, X. Lei, 2022, Bioorganic chemistry.

Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D development.

A. Bohrer, K. Bidasee, X. Lei, 2014, Endocrinology.

Research progress of PD‐L1 non‐glycosylation in cancer immunotherapy

Xiaoyan Yang, X. Lei, Zhizhong Xie, 2022, Scandinavian Journal of Immunology.

Macrophage polarization is linked to Ca2+-independent phospholipase A2β-derived lipids and cross-cell signaling in mice[S]

Alexander J. Nelson, C. Chalfant, Margaret A. Park, 2019, Journal of Lipid Research.

Design, synthesis and biological evaluation of tryptamine salicylic acid derivatives as potential antitumor agents.

Xuan Cao, D. He, X. Lei, 2019, MedChemComm.

Inhibition of Ca-Independent Phospholipase A2b (iPLA2b) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice

V. Magrioti, G. Kokotos, X. Lei, 2015 .

Inhibition of Ca2+-Independent Phospholipase A2β (iPLA2β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice

V. Magrioti, G. Kokotos, X. Lei, 2014, Diabetes.

Doxorubicin resistance mediated by cytoplasmic macrophage colony-stimulating factor is associated with switch from apoptosis to autophagic cell death in MCF-7 breast cancer cells

X. Lei, Shengsong Tang, Zhongcheng Mo, 2016, Experimental biology and medicine.

Design, synthesis and biological evaluation of 3',4',5'-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents.

Xuan Cao, X. Lei, Guotao Tang, 2018, MedChemComm.

Advances in antitumor research of HIF-1α inhibitor YC-1 and its derivatives.

X. Lei, Guotao Tang, Zhizhong Xie, 2023, Bioorganic chemistry.

β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis.

Varnavas D. Mouchlis, E. Dennis, V. Magrioti, 2019, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents

Yunmei Liu, Xuan Cao, X. Lei, 2018, Natural product research.

Synthesis of novel amino acid derivatives containing chrysin as anti-tumor agents against human gastric carcinoma MGC-803 cells

Jun He, Yunmei Liu, X. Lei, 2015, Medicinal Chemistry Research.

A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo

Xuan Cao, X. Lei, Zhizhong Xie, 2020, Drug development research.

Downregulation of eIF4G by microRNA-503 enhances drug sensitivity of MCF-7/ADR cells through suppressing the expression of ABC transport proteins

Xiaoyan Yang, X. Lei, Xi Li, 2017, Oncology letters.

Calcium-independent phospholipases A2 and their roles in biological processes and diseases

X. Lei, Jason W Ashley, S. Ramanadham, 2015, Journal of Lipid Research.

Genetic modulation of islet β-cell iPLA2β expression provides evidence for its impact on β-cell apoptosis and autophagy

J. Turk, A. Bohrer, X. Lei, 2013, Islets.

Nuclear M-CSF Accelerates DNA Replication and Cell Proliferation in HeLa Human Cervical Cancer Cells

S. Teng, X. Lei, T. Xiong, 2017 .

miR-503 inhibits proliferation making human hepatocellular carcinoma cells susceptible to 5‑fluorouracil by targeting EIF4E.

Jia Yu, Xiaoyan Yang, Jie Yin, 2017, Oncology reports.

A let-7b binding site SNP in the 3′-UTR of the Bcl-xL gene enhances resistance to 5-fluorouracil and doxorubicin in breast cancer cells

Xuyu Zu, Huifang Tang, X. Lei, 2015, Oncology letters.

Design, synthesis, and biological evaluation of 3′,4′,5′‐trimethoxy evodiamine derivatives as potential antitumor agents

D. He, X. Lei, Guotao Tang, 2021, Drug development research.

The Role of NcRNAs to Regulate Immune Checkpoints in Cancer

Sijun Deng, Xiaoyan Yang, X. Lei, 2022, Frontiers in Immunology.

Long non-coding RNA GAS5 in human cancer

Xiaoyan Yang, X. Lei, Zhizhong Xie, 2020, Oncology letters.

MiR-33b-5p sensitizes gastric cancer cells to chemotherapy drugs via inhibiting HMGA2 expression

Huali Yin, Xiaoyan Yang, X. Lei, 2017, Journal of drug targeting.

miRNA-195 sensitizes human hepatocellular carcinoma cells to 5-FU by targeting BCL-w.

Xuyu Zu, Jia Yu, Yunmei Liu, 2011, Oncology reports.

Amazing roles of extrachromosomal DNA in cancer progression.

Xiaoyan Yang, X. Lei, Yicun Jiang, 2022, Biochimica et biophysica acta. Reviews on cancer.

Progress on the role of extrachromosomal DNA in tumor pathogenesis and evolution

Qian Ning, X. Lei, Shengsong Tang, 2020, Clinical genetics.

Recent advances in Bcr‐Abl tyrosine kinase inhibitors for overriding T315I mutation

Xuan Cao, X. Lei, Guotao Tang, 2020, Chemical biology & drug design.

Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors.

X. Lei, Guotao Tang, Zhizhong Xie, 2021, Bioorganic chemistry.

The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y.

Qiong Chen, X. Lei, Shu-ya He, 2016, Gene.

Tumor-derived or non-tumor-derived exosomal noncodingRNAs and signaling pathways in tumor microenvironment.

Sijun Deng, Xiaoyan Yang, X. Lei, 2022, International immunopharmacology.

The Impact of the Ca2+-Independent Phospholipase A2β (iPLA2β) on Immune Cells

X. Lei, S. Ramanadham, A. AlMutairi, 2021, Biomolecules.

Let-7b binding site polymorphism in the B-cell lymphoma-extra large 3'UTR is associated with fluorouracil resistance of hepatocellular carcinoma.

X. Lei, Jin Ma, Ting Wang, 2015, Molecular medicine reports.

Non-coding RNAs: New therapeutic targets and opportunities for hepatocellular carcinoma

Qian Ning, Jia Yu, Xiaoyan Yang, 2016 .

Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β-Cell Apoptosis.

G. Kokotos, A. Kokotos, X. Lei, 2020, Journal of medicinal chemistry.

MicroRNA-98 sensitizes cisplatin-resistant human lung adenocarcinoma cells by up-regulation of HMGA2.

Jia Yu, Xiaoyan Yang, Jie Yin, 2013, Die Pharmazie.

Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in autophagy-induced hepatocellular carcinoma.

Qing Li, Xuyu Zu, Juan Zhou, 2020, Clinica chimica acta; international journal of clinical chemistry.

FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis.

Xuan Cao, X. Lei, Guotao Tang, 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

MiR-122 increases sensitivity of drug-resistant BEL-7402/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins.

Jia Yu, Jie Yin, Qiong Xiang, 2011, Pharmazie.

MicroRNA‑133a and microRNA‑326 co‑contribute to hepatocellular carcinoma 5‑fluorouracil and cisplatin sensitivity by directly targeting B‑cell lymphoma‑extra large.

Xuyu Zu, Jia Yu, Xiaoyan Yang, 2015, Molecular medicine reports.

Spontaneous Development of Endoplasmic Reticulum Stress That Can Lead to Diabetes Mellitus Is Associated with Higher Calcium-independent Phospholipase A2 Expression

S. Zhang, F. R. Papa, A. Bohrer, 2009, The Journal of Biological Chemistry.

Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway

X. Lei, Guotao Tang, Zhizhong Xie, 2020 .

Roles of ABCA1 in cancer.

Xiaoyan Yang, X. Lei, Kun Wu, 2022, Oncology letters.

Clinical crosstalk between microRNAs and gastric cancer (Review).

J. Ouyang, Xiaoyan Yang, X. Lei, 2021, International journal of oncology.

Calcium-independent Phospholipase A2 (iPLA2β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis*

A. Bohrer, X. Lei, S. Ramanadham, 2008, Journal of Biological Chemistry.

Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion.

K. Yarasheski, S. Zhang, X. Lei, 2009, American journal of physiology. Endocrinology and metabolism.

Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.

X. Lei, Guotao Tang, Runde Xiong, 2020, Bioorganic chemistry.

FB-15 inhibits MGC-803 cells growth by regulating energy metabolism.

X. Lei, Guotao Tang, Runde Xiong, 2020, Chemico-biological interactions.

Discovery of a Potential Multi-Target Anti-Tumor Agent via Structural Modification on Flavonoid

X. Lei, Guotao Tang, Zhizhong Xie, 2021, Polycyclic Aromatic Compounds.

Design, synthesis, and preliminary biological evaluation of 3′,4′,5′-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents

X. Lei, Guotao Tang, Runde Xiong, 2019, New Journal of Chemistry.

Let-7 g microRNA sensitizes fluorouracil-resistant human hepatoma cells.

Jia Yu, Xiaoyan Yang, Jie Yin, 2014, Die Pharmazie.

Emerging roles of noncoding RNAs in human cancers

Sijun Deng, Xiaoyan Yang, X. Lei, 2023, Discover Oncology.

Corrigendum to 'The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y' [Gene. 2016 Apr. 29. pii: S0378-1119(16)303079].

Qiong Chen, X. Lei, Shu-ya He, 2017, Gene.

Design, synthesis and biological evaluation of N-anthraniloyl tryptamine derivatives as pleiotropic molecules for the therapy of malignant glioma.

Zhen Wang, Honghua Zhang, X. Lei, 2021, European journal of medicinal chemistry.

MiR-4295 Promotes the Malignant Progression of Gastric Cancer via Targeting PTEN.

Xiaoyan Yang, X. Lei, Zhizhong Xie, 2021, Combinatorial chemistry & high throughput screening.

Emerging roles of ncRNAs regulating ABCC1 on chemotherapy resistance of cancer – a review

Feng Zhang, Xiaoyan Yang, X. Lei, 2023, Journal of chemotherapy.

Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived β-cells.

S. Barnes, K. Mitra, Jianhua Zhang, 2013, American journal of physiology. Endocrinology and metabolism.