Edward A. Motea

发表

Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase.

Edward A. Motea, A. Berdis, Anthony J. Berdis, 2010, Biochimica et biophysica acta.

Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer

D. Boothman, E. Bey, Xiumei Huang, 2020, Frontiers in Oncology.

Kub5-HeraRPRD1B Deficiency Promotes “BRCAness” and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers

J. Minna, L. Girard, Yang Xie, 2018, Clinical Cancer Research.

Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy

Edward A. Motea, Naveen K. Singh, S. Bhandare, 2020, Cancers.

The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair

H. Garner, Yang Xie, Yunyun Zhou, 2016, Nucleic acids research.

The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair

H. Garner, Yang Xie, Yunyun Zhou, 2016, Nucleic acids research.

XRN2 Links Transcription Termination to DNA Damage and Replication Stress

J. Manley, J. Morales, D. Boothman, 2016, PLoS genetics.

Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors.

D. Boothman, Kejin Zhou, Yunfeng Yan, 2017, Biomaterials.

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors.

Jun Yao, J. Minna, M. Peyton, 2016, Cancer cell.

A non-natural nucleoside with combined therapeutic and diagnostic activities against leukemia.

Irene Lee, Edward A. Motea, A. Berdis, 2012, ACS chemical biology.

RNA transcription termination factors and persistent R-loops: potential carcinogenic determinants after high or low LET IR.

M. Story, S. Burma, J. Morales, 2015 .

NQO1-dependent, Tumor-selective Radiosensitization of Non–small Cell Lung Cancers

Xian-Jin Xie, D. Gerber, D. Boothman, 2019, Clinical Cancer Research.

Probing the Chemistry and Enzymology of Translesion DNA Synthesis: Applications in Developing a Novel “Theranostic” Agent against Leukemia

Edward A. Motea, 2012 .

NQO1 bioactivatable drugs enhance radiation responses

Jinming Gao, D. Boothman, R. Brekken, 2016 .

Combined inhibition of Ref‐1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co‐culture models

T. Zimmers, K. Pollok, M. Kelley, 2020, Journal of cellular and molecular medicine.

Replication of a universal nucleobase provides unique insight into the role of entropy during DNA polymerization and pyrophosphorolysis.

Irene Lee, Edward A. Motea, A. Berdis, 2010, Biochemistry.

Modulators of Redox Metabolism in Head and Neck Cancer.

Melissa L. Kemp, D. Boothman, S. Planchon, 2017, Antioxidants & redox signaling.

Development of a ‘clickable’ non-natural nucleotide to visualize the replication of non-instructional DNA lesions

Irene Lee, Edward A. Motea, A. Berdis, 2011, Nucleic acids research.

Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis

Irene Lee, Edward A. Motea, A. Berdis, 2010, Nucleic acids research.

XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition

J. Morales, Megha Khandelwal, F. Fattah, 2020, Scientific Reports.

Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair

Shwu‐Yuan Wu, C. Chiang, W. Hittelman, 2014, Nucleic acids research.

Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.

Melissa C. Srougi, Wareef Kabbani, Longshan Li, 2014, Antioxidants & redox signaling.

Evaluating the Therapeutic Potential of a Non-Natural Nucleotide That Inhibits Human Ribonucleotide Reductase

Md. Faiz Ahmad, Edward A. Motea, A. Berdis, 2012, Molecular Cancer Therapeutics.

Development and characterization of a non-natural nucleoside that displays anticancer activity against solid tumors.

Yan Xu, Irene Lee, J. Golden, 2013, ACS chemical biology.

Insights into the Roles of Desolvation and π‐Electron Interactions during DNA Polymerization

Irene Lee, Edward A. Motea, A. Berdis, 2013, Chembiochem : a European journal of chemical biology.

Mechanism and dynamics of translesion DNA synthesis catalyzed by the Escherichia coli Klenow fragment.

Irene Lee, Edward A. Motea, A. Berdis, 2008, Biochemistry.

Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents

Edward A. Motea, A. Berdis, Jung-Suk Choi, 2017, Oncotarget.

NQO1-Bioactivatable Therapeutics as Radiosensitizers for Cancer Treatment

Jayne M. Silver, D. Boothman, E. Bey, 2020, Translational Research in Cancer.

Detecting Attomolar DNA-Damaging Anticancer Drug Activity in Cell Lysates with Electrochemical DNA Devices.

J. Slinker, Edward A. Motea, Dimithree Kahanda, 2021, ACS sensors.

Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors.

D. Boothman, Kejin Zhou, Yunfeng Yan, 2017, Biomaterials.

Evaluating the Therapeutic Potential of a Non-Natural Nucleotide That Inhibits Human Ribonucleotide Reductase

Md. Faiz Ahmad, Edward A. Motea, A. Berdis, 2012, Molecular Cancer Therapeutics.