Qian Huang

Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model.

M. Katharine Holloway, Adam J. Simon, Lixia Jin, 2006 .

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

M Katharine Holloway, Lixia Jin, Michelle Crouthamel, 2006, Journal of medicinal chemistry.

BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres.

Lixia Jin, Qian Huang, Janet Lineberger, 2006, Bioorganic & medicinal chemistry letters.

BACE-1 inhibition by a series of ψ[CH2NH] reduced amide isosteres

M. Katharine Holloway, Adam J. Simon, Lixia Jin, 2006 .

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.

Adam J. Simon, Georgia B. McGaughey, Philippe G. Nantermet, 2010, Bioorganic & medicinal chemistry letters.

A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels

Min Xu, Xiao-Ping Shi, Yuanjiang Yu, 2006, Molecular and Cellular Neuroscience.

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.

Paul Zuck, Georgia B McGaughey, M Katharine Holloway, 2008, Journal of medicinal chemistry.

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.

M Katharine Holloway, Gergely M Makara, Zhongguo Chen, 2004, Journal of medicinal chemistry.