Alykhan F. Shamji

发表

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Jill P. Mesirov, Dong Gao, Stuart L. Schreiber, 2017, Nature.

Discovery of a Small-Molecule Probe for V-ATPase Function

Stuart L. Schreiber, Szu-Yu Kuo, Ramnik J. Xavier, 2015, Journal of the American Chemical Society.

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays

Stuart L. Schreiber, Paul J. Hergenrother, S. Schreiber, 2002, Nature.

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

Stuart L. Schreiber, Paul A. Clemons, Nicole E. Bodycombe, 2010, Proceedings of the National Academy of Sciences.

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

Stuart L. Schreiber, Vlado Dančík, Paul A. Clemons, 2015, Proceedings of the National Academy of Sciences.

Transforming Big Data into Cancer-Relevant Insight: An Initial, Multi-Tier Approach to Assess Reproducibility and Relevance

Ken Chen, Chris Sander, Olivier Gevaert, 2016, Molecular Cancer Research.

Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins

Stuart L. Schreiber, S. Schreiber, F. Kuruvilla, 2000, Current Biology.

Regulation of Ferroptotic Cancer Cell Death by GPX4

Matthew E. Welsch, P. Clemons, S. Schreiber, 2014, Cell.

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Angela N. Brooks, Jacob K. Asiedu, Joshua A. Bittker, 2017, Cell.

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

T. Golub, P. Tamayo, K. Ross, 2016, Nature Biotechnology.

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

Joshua A. Bittker, Nicole E. Bodycombe, S. Gill, 2015, Nature chemical biology.

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.

Fatima Al-Shahrour, Anne E Carpenter, Benito Munoz, 2013, Nature chemical biology.

Selective killing of cancer cells with a small molecule targeting stress response to ROS

T. Golub, S. Carr, S. Schreiber, 2011, Nature.

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

Jacob D. Jaffe, Christine E. Becker, M. Daly, 2014, Proceedings of the National Academy of Sciences.

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

R. Xavier, S. Schreiber, A. Shamji, 2013, Gastroenterology.

Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.

M. Daly, R. Xavier, S. Schreiber, 2013, ACS chemical biology.

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

Tudor I. Oprea, Jennifer E. Golden, Joshua A. Bittker, 2015, Cell.

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

Joshua A. Bittker, Nicole E. Bodycombe, P. Clemons, 2015, Cancer discovery.

Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

T. Golub, S. Carr, S. Schreiber, 2015, Nature.

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins.

S. Schreiber, F. Kuruvilla, A. Shamji, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Joshua A. Bittker, M. Daly, R. Xavier, 2017, Proceedings of the National Academy of Sciences.

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

Anne E Carpenter, Joshua A Bittker, Nicole E Bodycombe, 2017, GigaScience.

Identification of cancer cytotoxic modulators of PDE3A by predictive chemogenomics

Benito Munoz, Paul A Clemons, Aviad Tsherniak, 2015, Nature chemical biology.

A genetic basis for the variation in the vulnerability of cancer to DNA damage

P. Tamayo, P. Clemons, S. Schreiber, 2016, Nature Communications.

An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules

Joshua C. Gilbert, Joshua A. Bittker, Andrew J. Wilson, 2013, Cell.

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

R. Xavier, M. Schirmer, S. Schreiber, 2015, eLife.

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.

Geoffrey M. Nelson, Phillip G. Montgomery, Phillip G Montgomery, 2019, Cell reports.

Small-molecule and CRISPR screening converge to reveal RTK dependencies in pediatric rhabdoid tumors

Geoffrey M. Nelson, Phillip G. Montgomery, Francisca, 2020 .

KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.

Andrew J. Wilson, P. Tamayo, S. Schreiber, 2015, Cancer research.

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

T. Golub, P. Clemons, S. Schreiber, 2015, Cell reports.

Integration of growth factor and nutrient signaling: implications for cancer biology.

S. Schreiber, A. Shamji, P. Nghiem, 2003, Molecular cell.

Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

Paul A Clemons, Nevan J Krogan, Stuart L Schreiber, 2015, Cancer discovery.

A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma

S. Schreiber, A. Shamji, B. Wagner, 2012, ACS chemical biology.

Title: KRAS genomic status predicts the sensitivity of ovarian cancer cells to decitabine Running Title: KRAS status predicts sensitivity to decitabine in ovarian cancer Authors: Stewart ML, Tamayo

Chang, Andrew J. Wilson, Ym, 2015 .

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs

S. Schreiber, A. Shamji, B. Wagner, 2012, Proceedings of the National Academy of Sciences.

DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

J. Mesirov, P. Tamayo, P. Clemons, 2016, Clinical Cancer Research.

Rpd3p relocation mediates a transcriptional response to rapamycin in yeast.

S. Schreiber, B. Bernstein, A. Shamji, 2004, Chemistry & biology.

3 p Relocation Mediates a Transcriptional Response to Rapamycin in Yeast repression

S. Schreiber, B. Bernstein, A. Shamji, 2004 .

The kinase DYRK 1 A reciprocally regulates the differentiation of Th 17 and regulatory T cells

R. Xavier, M. Schirmer, S. Schreiber, 2015 .

ReviewIntegration of Growth Factor and Nutrient Signaling : Implications for Cancer

S. Schreiber, A. Shamji, P. Nghiem, 2003 .

Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway

Jeremy R. Duvall, S. Schreiber, A. Shamji, 2013, Journal of the American Chemical Society.

NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

P. Clemons, S. Schreiber, A. Ramos, 2014, ACS chemical biology.

Small-molecule control of cytokine function: new opportunities for treating immune disorders.

R. Xavier, S. Schreiber, A. Shamji, 2014, Current opinion in chemical biology.

Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses

Nicole E. Bodycombe, P. Clemons, A. Shamji, 2014, Journal of biomolecular screening.

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

Anne E Carpenter, Joshua A. Bittker, Nicole E. Bodycombe, 2014, Proceedings of the National Academy of Sciences.

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells

Joshua C. Gilbert, P. Clemons, S. Schreiber, 2012, Proceedings of the National Academy of Sciences.

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells

S. Schreiber, A. Shamji, B. Wagner, 2013, Cell Death and Disease.

Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

Anne E Carpenter, Katherine L. Sokolnicki, T. Golub, 2013, PloS one.

Integrated genetic and pharmacologic interrogation of rare cancers

S. Gill, W. Hahn, P. Clemons, 2016, Nature Communications.

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

T. Golub, S. Carr, S. Schreiber, 2018, Nature.

Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.

S. Schreiber, A. Shamji, G. Dunn, 2016, ACS medicinal chemistry letters.

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

T. Golub, S. Carr, S. Schreiber, 2012, Nature.

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

M. Daly, J. Rioux, R. Xavier, 2015, Immunity.

Towards patient-based cancer therapeutics

Benito Munoz, Michelle Palmer, Paul A Clemons, 2010, Nature Biotechnology.

The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4+ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2021, Molecular and cellular biology.

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2019, bioRxiv.

DCA promotes a novel tolerogenic program in CD 4 + T cells by inhibiting CDK 8

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2019 .

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

Jacob D. Jaffe, Christine E. Becker, M. Daly, 2014, Proceedings of the National Academy of Sciences.

Selective killing of cancer cells with a small molecule targeting stress response to ROS

T. Golub, S. Carr, S. Schreiber, 2011, Nature.

Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.

Stuart L Schreiber, Alykhan F Shamji, Angela N Koehler, 2003, Journal of the American Chemical Society.

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Joshua A. Bittker, M. Daly, R. Xavier, 2017, Proceedings of the National Academy of Sciences.

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

Daniel J. O'Connell, R. Xavier, S. Schreiber, 2014, Proceedings of the National Academy of Sciences.

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

Daniel J. O'Connell, R. Kolde, R. Xavier, 2017, Nature chemical biology.

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

Joshua A. Bittker, Nicole E. Bodycombe, P. Clemons, 2015, Cancer discovery.

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo.

R. Xavier, S. Schreiber, A. Shamji, 2016, ACS chemical biology.

Selective killing of cancer cells with a small molecule targeting stress response to ROS

T. Golub, S. Carr, S. Schreiber, 2011, Nature.

Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening.

Stuart L Schreiber, S. Schreiber, A. Shamji, 2007, Chemistry & biology.

Automated Structure–Activity Relationship Mining

S. Haggarty, P. Clemons, S. Schreiber, 2014, Journal of biomolecular screening.

Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors

S. Schreiber, F. Kuruvilla, A. Shamji, 2001, Proceedings of the National Academy of Sciences of the United States of America.