Mark T Miedel

发表

A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency.

Ivet Bahar, Joshua A. Benson, I. Bahar, 2014, Human molecular genetics.

THE ROLE OF MUCOLIPIN-1 IN PATHOGENESIS OF THE LYSOSOMAL STORAGE DISEASE MUCOLIPIDOSIS TYPE IV

Mark T Miedel, Mark T. Miedel, 2008 .

The Aggregation-Prone Intracellular Serpin SRP-2 Fails to Transit the ER in Caenorhabditis elegans

G. Silverman, L. O’Reilly, C. Luke, 2015, Genetics.

Posttranslational Cleavage and Adaptor Protein Complex-dependent Trafficking of Mucolipin-1*

Jennifer R. Bruns, O. Weisz, L. Traub, 2006, Journal of Biological Chemistry.

Isolation of serpin-interacting proteins in C. elegans using protein affinity purification.

N. Yates, G. Silverman, C. Luke, 2014, Methods.

Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes

Adrian V. Lee, D. L. Taylor, S. Oesterreich, 2018, Oncology.

Membrane traffic and turnover in TRP-ML1–deficient cells: a revised model for mucolipidosis type IV pathogenesis

K. Kiselyov, O. Weisz, Y. Rbaibi, 2008, The Journal of experimental medicine.

The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in C. elegans

C. Luke, D. Perlmutter, S. Pak, 2015 .

A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies

Daniel E. Lefever, D. L. Taylor, I. Bahar, 2022, Metabolites.

Loss of Lysosomal Ion Channel Transient Receptor Potential Channel Mucolipin-1 (TRPML1) Leads to Cathepsin B-dependent Apoptosis*

K. Kiselyov, O. Weisz, Mark T Miedel, 2012, The Journal of Biological Chemistry.

ADP-ribosylation Factor 1-independent Protein Sorting and Export from the trans-Golgi Network*

O. Weisz, Mark T Miedel, Mark T. Miedel, 2004, Journal of Biological Chemistry.

Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit*

G. Silverman, C. Luke, Mark T Miedel, 2016, The Journal of Biological Chemistry.

Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development

F. Marincola, D. L. Taylor, J. Berzofsky, 2017, Journal of Translational Medicine.

A 3D Microfluidic Liver Model for High Throughput Compound Toxicity Screening in the OrganoPlate®.

Anthony D. Saleh, L. Vernetti, A. Gough, 2020, Toxicology.

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

J. Fitzpatrick, G. Silverman, C. Luke, 2022, Communications Biology.

A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.

Joshua A. Benson, Simon C Watkins, S. Züchner, 2014, Human molecular genetics.

Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors

Daniel E. Lefever, A. Soto-Gutiérrez, L. Vernetti, 2021, Experimental biology and medicine.

SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.

G. Silverman, C. Luke, S. Pak, 2015, Biochemistry.

mucolipidosis type IV pathogenesis Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for

E. Ikonen, O. Weisz, Y. Rbaibi, 2009 .

Serpins in Caenorhabditis elegans

G. Silverman, L. O’Reilly, C. Luke, 2015 .

Using C. elegans to identify the protease targets of serpins in vivo.

T. Conrads, B. Hood, G. Silverman, 2011, Methods in enzymology.

Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency

G. Silverman, L. O’Reilly, C. Luke, 2015, PloS one.

Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System

D. L. Taylor, A. Gough, A. Stern, 2019, Scientific Reports.

the RNAi pathway to misfolded protein turnover

Yan Wang, Joshua A. Benson, Simon C Watkins, 2014 .

A Pro-Cathepsin L Mutant Is a Luminal Substrate for Endoplasmic-Reticulum-Associated Degradation in C. elegans

G. Silverman, C. Luke, Olivia S. Long, 2012, PloS one.

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury

D. L. Taylor, C. Battista, J. Beaudoin, 2023, International journal of molecular sciences.

Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis

K. Kiselyov, O. Weisz, Y. Rbaibi, 2008 .

Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants

Z. Wang, Mark T Miedel, J. Behari, 2023, International journal of molecular sciences.

The Aggregation-Prone Intracellular Serpin SRP-2 Fails to Transit the ER in Caenorhabditis elegans

G. Silverman, C. Luke, D. Perlmutter, 2015, Genetics.

Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system.

L. Vernetti, A. Gough, Mark T Miedel, 2023, Lab on a chip.