S. Atlas

发表

Massimo Volpe, J. Laragh, M. Volpe, 2005 .

THE EFFECT OF CALCIUM CHANNEL Blockers ON moderate or severe ALBUMINURIA IN DIABETIC, HYPERTENSIVE PATIENTS: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials.

C. Rosendorff, S. Atlas, E. Cativo, 2020, The American journal of medicine.

Clinical Events in High-Risk Hypertensive Patients Randomly Assigned to Calcium Channel Blocker Versus Angiotensin-Converting Enzyme Inhibitor in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

B. Davis, Jackson T. Wright, P. Whelton, 2006, Hypertension.

Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes.

D. Nebert, E. Vesell, S. Atlas, 1976, Cancer research.

Changes in collagenase and collagen gene expression after induction of aortocaval fistula in rats.

S. Atlas, F. Siri, C. Eng, 2001, American journal of physiology. Heart and circulatory physiology.

Atrial Natriuretic Factor

S. Atlas, T. Maack, 2011 .

Atrial natriuretic factor: structure and functional properties.

J. Laragh, S. Atlas, H. Kleinert, 1985, Kidney international.

Human renin (REN) gene locus: BglII, RsaI and TaqI RFLPs.

P. Frossard, S. Atlas, P. González, 1986, Nucleic acids research.

Two RFLPs at the human renin (ren) gene locus.

J. Fiddes, L. Fritz, P. Frossard, 1986, Nucleic acids research.

Prorenin and other large molecular weight forms of renin.

J. Laragh, J. Sealey, S. Atlas, 1980, Endocrine reviews.

PLASMA RENIN AND "PRORENIN" IN ESSENTIAL HYPERTENSION DURING SODIUM DEPLETION, BETA-BLOCKADE, AND REDUCED ARTERIAL PRESSURE

J. Laragh, J. Sealey, S. Atlas, 1977, The Lancet.

Prorenin in plasma and kidney.

J. Laragh, J. Sealey, S. Atlas, 1983, Federation proceedings.

Cyclical secretion of prorenin during the menstrual cycle: synchronization with luteinizing hormone and progesterone.

J. Laragh, N. Glorioso, J. Sealey, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Plasma Prorenin in Normal, Hypertensive, and Anephric Subjects and Its Effect on Renin Measurements

J. Laragh, J. Sealey, S. Atlas, 1977, Circulation research.

Immunological evidence that inactive renin is prorenin.

L. Fritz, J. Sealey, S. Atlas, 1985, Biochemical and biophysical research communications.

New monoclonal antibodies directed against human renin. Powerful tools for the investigation of the renin system.

J. Ménard, P. Corvol, S. Atlas, 1984, The Journal of clinical investigation.

of the Renin System

J. Ménard, P. Gros, B. Pau, 1984 .

An inactive, prorenin-like substance in human kidney and plasma.

J. Laragh, J. Sealey, S. Atlas, 1980, Clinical science.

Plasma prorenin in first-trimester pregnancy: relationship to changes in human chorionic gonadotropin.

J. Laragh, M. Druzin, J. Sealey, 1985, American journal of obstetrics and gynecology.

Position Paper: Extravascular and Plasma Prorenin and Renin

J. Laragh, J. Sealey, S. Atlas, 1981 .

Effect of captopril and aprotinin on inactive renin.

J. Laragh, J. Sealey, K. Stumpe, 1981, The Journal of clinical endocrinology and metabolism.

Initiation of plasma prorenin activation by Hageman factor-dependent conversion of plasma prekallikrein to kallikrein.

J. Laragh, J. Sealey, M. Silverberg, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Stimulation of plasma prorenin by gonadotropic hormones.

J. Laragh, N. Glorioso, J. Sealey, 1985, American journal of obstetrics and gynecology.

Prorenin in high concentrations in human ovarian follicular fluid.

J. Laragh, N. Glorioso, J. Sealey, 1986, Science.

Vitamin D levels and the risk of hypertension

S. Atlas, Sandeep S. Patel, 2007, Current hypertension reports.

Immediate converting-enzyme inhibition with intravenous enalapril in chronic congestive heart failure.

J. Laragh, R. Cody, X. Prida, 1985, The American journal of cardiology.

Research Article Association between transforming growth factor-b1 and left ventricular mass and diameter in hypertensive patients

C. Rosendorff, S. Atlas, J. Almendral, 2010 .

Association between transforming growth factor-beta(1) and left ventricular mass and diameter in hypertensive patients.

C. Rosendorff, S. Atlas, J. Almendral, 2010, Journal of the American Society of Hypertension : JASH.

Renin system activity as a determinant of response to treatment in hypertension and heart failure.

J. Laragh, R. Cody, D. Case, 1983, Hypertension.

Benefits of renin-angiotensin system blockade in advanced renal insufficiency.

S. Atlas, S. Mangat, 2006, Current hypertension reports.

The Impact of Environmental Factors on the Mortality of Patients with Chronic Heart Failure.

C. Rosendorff, S. Atlas, P. López, 2021, The American journal of cardiology.

Genetically regulated aryl hydrocarbon hydroxylase induction in the eye: possible significance of the drug-metabolizing enzyme system for the retinal pigmented epithelium-choroid.

D. Nebert, S. Atlas, H. Shichi, 1975, Experimental eye research.

Relationship of atrial natriuretic factor to left ventricular volume and mass.

J. Laragh, R. Pini, R. Devereux, 1989, American heart journal.

Plasma atrial natriuretic factor in essential hypertension: relation to cardiac size, function and systemic hemodynamics.

J. Laragh, R. Cody, M. Roman, 1989, Journal of the American College of Cardiology.

Atrial natriuretic peptide: a new factor in hormonal control of blood pressure and electrolyte homeostasis.

J. Laragh, S. Atlas, 1986, Annual review of medicine.

Interruption of the Renin‐Angiotensin System in Hypertensive Patients by Captopril Induces Sustained Reduction in Aldosterone Secretion, Potassium Retention and Natriuresis

J. Laragh, D. Mckinstry, D. Case, 1979, Hypertension.

Human urinary kallikrein converts inactive to active renin and is a possible physiological activator of renin

J. Laragh, J. Sealey, S. Atlas, 1978, Nature.

21 – The Ah Locus: Genetic Regulation of the Enzymes which Metabolize Polycyclic Hydrocarbons and the Risk for Cancer

R. E. Kouri, D. Nebert, S. Atlas, 1978 .

Maintenance of forearm vasodilator action of atrial natriuretic factor in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.

J. Laragh, R. Cody, S. Atlas, 1992, The American journal of cardiology.

The Renin-Angiotensin-Aldosterone System and Atrial Natriuretic Factor

J. Laragh, J. Sealey, S. Atlas, 1989 .

Characterization of inactive renin ("prorenin") from renin-secreting tumors of nonrenal origin. Similarity to inactive renin from kidney and normal plasma.

J. Laragh, J. Sealey, M. Aurell, 1984, The Journal of clinical investigation.

Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function, and the renin-aldosterone system in dogs.

J. Laragh, E. Vaughan, S. Atlas, 1984, The American journal of medicine.

The renin system for understanding human hypertension: evidence for blood pressure control by a bipolar vasoconstriction-volume mechanism. Prorenin as a determinant of renin secretion.

J. Laragh, J. Sealey, S. Atlas, 1982, Clinical and experimental hypertension. Part A, Theory and practice.

J. Laragh, P. Corvol, J. Sealey, 1982, Hypertension.

Detection and Isolation of Inactive, Large Molecular Weight Renin in Human Kidney and Plasma

J. Laragh, J. Sealey, S. Atlas, 1981, Hypertension.

8 Renin in Essential Hypertension

D. Case, S. Atlas, 1981 .

The renin system and atrial natriuretic hormone in congestive heart failure.

J. Laragh, R. Cody, S. Atlas, 2009, Acta medica Scandinavica. Supplementum.

Atrial natriuretic factor: a new hormone of cardiac origin.

S. Atlas, 1986, Recent progress in hormone research.

Long-term efficacy of captopril in renovascular and essential hypertension.

J. Laragh, D. Case, S. Atlas, 1982, The American journal of cardiology.

Immediate and Delayed Antihypertensive Effects of Angiotensin-Converting Enzyme Inhibition with Captopril

J. Laragh, D. Case, J. Sealey, 1981 .

Carcinogenic benzo(a)pyrene metabolites bound to DNA: metabolic formation by human cultured lymphocytes and by human liver microsomes.

A. Boobis, D. Nebert, S. Atlas, 1978, Pharmacology.

Relationship of increased plasma atrial natriuretic factor and renal sodium handling during immersion-induced central hypervolemia in normal humans.

M. Epstein, R. Loutzenhiser, S. Atlas, 1987, The Journal of clinical investigation.

Diagnosis and Treatment of Primary Hyperaldosteronism

J. Laragh, J. Blumenfeld, E. Vaughan, 1994, Annals of Internal Medicine.

Effects of atrial natriuretic factor on the kidney and the renin-angiotensin-aldosterone system.

S. Atlas, T. Maack, 1987, Endocrinology and metabolism clinics of North America (Print).

Efficacy and safety of Omapatrilat, a vasopeptidase inhibitor

R. Zusman, S. Atlas, M. Kochar, 1999 .

Hormonal and metabolic effects of angiotensin converting enzyme inhibitors. Possible differences between enalapril and captopril.

J. Laragh, D. Case, S. Atlas, 1984, The American journal of medicine.

Effect of trypsin or acid treatment on dog plasma renin activity measurements.

J. Laragh, J. Gallagher, J. Sealey, 1980, Endocrinology.

Linking the kallikrein and renin systems via activation of inactive renin: new data and a hypothesis.

J. Laragh, J. Sealey, S. Atlas, 1978, The American journal of medicine.

Cardiovascular effects of atrial natriuretic factor in anesthetized and conscious dogs.

J. Laragh, M. Volpe, S. Atlas, 1986, Hypertension.

Captopril Compared with Other Antirenin System Agents in Hypertensive Patients: Its Triphasic Effects on Blood Pressure and Its Use to Identify and Treat the Renin Factor

J. Laragh, D. Case, J. Sealey, 1980, Hypertension.

2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically "nonresponsive" at Ah locus.

D. Jerina, R. E. Kouri, D. Nebert, 1978, Cancer research.

Atrial natriuretic peptide synthesis in atrial tumors of transgenic mice.

J. Laragh, J. Baxter, D. Gardner, 1992, The American journal of physiology.

Cloning and sequence analysis of the cDNA for the rat atrial natriuretic factor precursor

J. Fiddes, J. Laragh, J. Lewicki, 1984, Nature.

Acute and Chronic Treatment of Severe and Malignant Hypertension with the Oral Angiotensin‐converting Enzyme Inhibitor Captopril

J. Laragh, D. Case, S. Atlas, 1981, Circulation.

Position Paper: Physiologic Effects and Diagnostic Relevance of Acute Converting Enzyme Blockade

J. Laragh, D. Case, S. Atlas, 1981 .

Reactive hyper-reninaemia to angiotensin blockade identifies renovascular hypertension.

J. Laragh, D. Case, S. Atlas, 1979, Clinical science.

Phentolamine testing for alpha adrenergic participation in hypertensive patients: Independence from renin profiles

J. Drayer, M. Weber, J. H. Laragh, 1977, Clinical pharmacology and therapeutics.

The Ah locus: aromatic hydrocarbon responsiveness... of mice and men.

D. Nebert, S. Atlas, 1978, Human genetics. Supplement.

Renal responses to atrial natriuretic factor in patients with congestive heart failure.

J. Laragh, R. Cody, S. Atlas, 1988, European heart journal.

Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide

J. Laragh, J. Lewicki, A. Januszewicz, 1984, Nature.

In vivo left ventricular anatomy in rats with two‐kidney, one clip and one‐kidney, one clip renovascular hypertension

J. Laragh, R. Devereux, G. de Simone, 1992, Journal of hypertension.

Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems.

S. Thorgeirsson, A. Boobis, D. Nebert, 1977, The Journal of biological chemistry.

Ca-dependent hemodynamic and natriuretic effects of atrial extract in isolated rat kidney.

J. Laragh, J. Sealey, S. Atlas, 1984, The American journal of physiology.

Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa.

T. Goodfriend, S. Atlas, M. Elliott, 1984, Life sciences.

Diurnal and postural variations in plasma atrial natriuretic factor, plasma guanosine 3':5'-cyclic monophosphate and sodium excretion.

J. Laragh, G. James, J. Sealey, 1990, Clinical science.

Reduction of atrial natriuretic factor circulating levels by endogenous sympathetic activation in hypertensive patients.

J. Laragh, M. Condorelli, C. Indolfi, 1988, Circulation.

BglII dimorphism at the human atrial natriuretic peptide (ANP) gene locus.

J. Fiddes, B. Greenberg, P. Frossard, 1986, Nucleic acids research.

Relationship between renal hemodynamic and natriuretic effects of atrial natriuretic factor.

J. Laragh, E. Vaughan, M. Volpe, 1986, The American journal of physiology.

Use of First‐Dose Response or Plasma Renin Activity to Predict the Long‐Term Effect of Captopril: Identification of Triphasic Pattern of Blood Pressure Response

J. Laragh, D. Case, J. Sealey, 1980, Journal of cardiovascular pharmacology.

Renal hemodynamic and natriuretic effects of atrial natriuretic factor.

M. G. Cogan, S. Atlas, T. Maack, 1986, Federation proceedings.

Inhibition of human renin by rat plasma. Rat angiotensinogen is a competitive inhibitor of the human renin-substrate interaction.

J. Laragh, J. Sealey, S. Atlas, 1992, American journal of hypertension.

Atrial natriuretic factor in normal and hypertensive pregnancy.

J. Laragh, M. Druzin, P. August, 1989, American journal of obstetrics and gynecology.

Effects of atrial natriuretic factor on blood pressure and the renin-angiotensin-aldosterone system.

J. Laragh, M. Volpe, R. Sosa, 1986, Federation proceedings.

Relationship between plasma ANF responsiveness and renal sodium handling in cirrhotic humans.

P. Norsk, M. Epstein, R. Loutzenhiser, 1989, American journal of nephrology.

Exercise-induced secretion of atrial natriuretic factor and its relation to hemodynamic and sympathetic stimulation in untreated essential hypertension.

J. Laragh, R. Cody, S. Atlas, 1991, The American journal of cardiology.

Atrial Natriuretic Factor and Its Clinical Implications

J. Laragh, S. Atlas, M. Pecker, 1990 .

Physiologic and Pharmacologic Studies of Atrial Natriuretic Factor: A Natriuretic and Vasoactive Peptide

J. Laragh, R. Cody, S. Atlas, 1987, Journal of clinical pharmacology.

Physiological Actions of Atrial Natriuretic Factor

J. Laragh, S. Atlas, 1987 .

Role of increased glomerular filtration rate in atrial natriuretic factor-induced natriuresis in the rat.

S. Atlas, T. Maack, M. Camargo, 1986, Life sciences.

Elevated levels of plasma prorenin (inactive renin) in diabetic and nondiabetic patients with autonomic dysfunction.

M. Grant, R. Misbin, S. Atlas, 1987, The Journal of clinical endocrinology and metabolism.

Increases in circulating atrial natriuretic factor during immersion-induced central hypervolaemia in normal humans.

M. Epstein, R. Loutzenhiser, S. Atlas, 1986, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Differing hemodynamic responses to atrial natriuretic factor in two models of hypertension.

J. Laragh, N. Glorioso, M. Volpe, 1986, The American journal of physiology.

Atrial natriuretic factor inhibits angiotensin-, norepinephrine-, and potassium-induced vascular contractility.

J. Laragh, A. Januszewicz, J. Sealey, 1984, Hypertension.

Increased plasma renin and aldosterone in patients treated with cisplatin-based chemotherapy for metastatic germ-cell tumors.

G. Bosl, J. Preibisz, J. Sealey, 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The unique steroidogenesis of the aldosteronoma in the differential diagnosis of primary aldosteronism.

J. Blumenfeld, E. Vaughan, S. Atlas, 1993, The Journal of clinical endocrinology and metabolism.

Proteinuria during long-term captopril therapy.

J. Laragh, D. Case, J. Mouradian, 1980, JAMA.

Effects of atrial natriuretic factor on human platelet function.

R. de Caterina, M. Volpe, S. Atlas, 1985, Life Science.

Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses.

J. Laragh, M. Volpe, J. Sealey, 1990, Circulation research.

Effects of atrial natriuretic factor on urinary concentration of catecholamines and renin secretion in dogs.

D. Goldstein, J. Sowers, M. Thames, 1988, Biochemical and biophysical research communications.

Cardiac secretion of atrial natriuretic factor with exercise in chronic congestive heart failure patients.

J. Laragh, R. Cody, S. Atlas, 1992, Journal of applied physiology.

Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.

Andrew, J. Laragh, Robert, 1986, The Journal of clinical investigation.

Effect of atrial natriuretic factor on renin secretion, plasma renin and aldosterone in dogs with acute unilateral renal artery constriction.

J. Laragh, N. Glorioso, E. Vaughan, 1985, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Antihypertensive and aldosterone-lowering effects of synthetic atrial natriuretic factor in renin-dependent renovascular hypertension.

J. Laragh, J. Lewicki, E. Vaughan, 1984, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Increased plasma atrial natriuretic factor and reduced plasma renin in patients with poorly controlled diabetes mellitus.

J. Laragh, G. James, J. Sealey, 1989, Clinical science.

Reversible Acid-Activation of Inactive Renin: Evidence Favouring a Unimolecular Reaction

J. Laragh, J. Sealey, S. Atlas, 1982 .

Activation of inactive plasma renin: evidence that both cryoactivation and acid-activation work by liberating a neutral serine protease from endogenous inhibitors.

J. Laragh, J. Sealey, S. Atlas, 1978, Clinical science and molecular medicine. Supplement.

PROTEASE AS ENDOGENOUS ACTIVATOR OF INACTIVE RENIN

J. Laragh, J. Sealey, S. Atlas, 1978, The Lancet.

Activation of a Prorenin‐Like Substance in Human Plasma by Trypsin and by Urinary Kallikrein

J. Laragh, J. Sealey, S. Atlas, 1979, Hypertension.

The Renin-Angiotensin Aldosterone System: Pathophysiological Role and Pharmacologic Inhibition

S. Atlas, 2007, Journal of managed care pharmacy : JMCP.

Genetic association of increases in naphthalene, acetanilide, and biphenyl hydroxylations with inducible aryl hydrocarbon hydroxylase in mice.

D. Nebert, S. Atlas, 1976, Archives of biochemistry and biophysics.

Apparent molecular size difference between plasma and renal inactive renins.

J. Laragh, J. Sealey, S. Atlas, 1982, Clinical and experimental hypertension. Part A, Theory and practice.

Aryl hydrocarbon hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

R. E. Kouri, D. Nebert, S. Atlas, 1974, Life sciences.

Clinical experience with blockade of the renin-angiotensin-aldosterone system by an oral converting-enzyme inhibitor (SQ 14,225, captopril) in hypertensive patients.

J. Laragh, D. Case, J. Sealey, 1978, Progress in cardiovascular diseases.

Species differences in the substrate specificity of hepatic cytochrome P-448 from polycyclic hydrocarbon-treated animals.

S. Thorgeirsson, A. Boobis, J. Felton, 1979, Biochemical pharmacology.

The captopril test for identifying renovascular disease in hypertensive patients.

J. Laragh, T. Pickering, D. Case, 1986, The American journal of medicine.

Atrial natriuretic hormone: a regulator of blood pressure and volume homeostasis.

J. Laragh, S. Atlas, 1988, Kidney international. Supplement.

RENIN ACTIVATION BY TRYPSIN AND KALLIKREINjSealey

J. Laragh, J. Sealey, S. Atlas, 2005 .

Effect of Atrial Natriuretic Factor on Blood Pressure, Renin, and Aldosterone in Goldblatt Hypertension

J. Laragh, E. Vaughan, M. Volpe, 1985, Hypertension.

The Effect of Vegan Diets on Blood Pressure in Adults: A Meta-Analysis of Randomized Controlled Trials.

C. Rosendorff, S. Atlas, E. Cativo, 2019, The American journal of medicine.

Hyperreninemia and secondary hyperaldosteronism in a patient with pheochromocytoma and von Hippel-Lindau disease.

S. Atlas, A. Distler, J. Nussberger, 1992, Nephron.

Relationship between plasma renin and cortisol in hypertensive patients.

J. Laragh, D. Case, J. Sealey, 1981, Clinical science.

Renin-Angiotensin Aldosterone System and Hypertension: Current Approaches and Future Directions

W. White, J. Pool, J. Flack, 2007, Journal of Managed Care Pharmacy : JMCP.

Table of Contents Renin-Angiotensin Aldosterone System and Hypertension : Current Approaches and Future Directions

W. White, J. Pool, J. Flack, 2007 .

Trial the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Calcium Channel Blocker Versus Angiotensin-Converting Enzyme Inhibitor in Clinical Events in High-Risk Hypertensive Patients Randomly

B. Davis, W. Cushman, M. Proschan, 2006 .

Pharmacogenetics: a possible pragmatic perspective in neoplasm predictability.

D. Nebert, S. Atlas, 1978, Seminars in oncology.

Relation of blood viscosity to demographic and physiologic variables and to cardiovascular risk factors in apparently normal adults.

S Chien, J. Laragh, S. Chien, 1990, Circulation.

Gender differences in left ventricular anatomy, blood viscosity and volume regulatory hormones in normal adults.

S Chien, J. Laragh, S. Chien, 1991, The American journal of cardiology.

Inhibitors of the renin-angiotensin system. Effects on blood pressure, aldosterone secretion and renal function.

D. Case, S. Atlas, A. Niarchos, 1983, American journal of nephrology.

Atrial natriuretic factor (auriculin): structure and biological effects.

J. Laragh, J. Lewicki, M. Volpe, 1985, Journal of clinical hypertension.

Inducible monooxygenase activities and 3-methyl-cholanthrene-initiated tumorigenesis in mouse recombinant inbred sublines.

B. Taylor, D. Nebert, B. Diwan, 1976, Genetics.

Atrial Natriuretic Factor in Heart Failure: Endogenous Activity and Response to Exogenous Administration

J. Laragh, R. Cody, S. Atlas, 1986 .

Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice.

D. Nebert, S. Atlas, J. Zweier, 1980, Developmental pharmacology and therapeutics.

Central Sympatholytic Drugs

K. Kario, W. Vongpatanasin, S. Atlas, 2011, Journal of clinical hypertension.

Altered renin and aldosterone excretion in patients treated for metastatic germ cell tumours.

G. Bosl, J. Preibisz, J. Sealey, 1987, International journal of andrology.

Characterization of human prorenin expressed in mammalian cells from cloned cDNA.

J. Fiddes, J. Shine, J. Baxter, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Plasmin can activate plasma prorenin but is not required for the alkaline phase of acid activation.

J. Laragh, J. Sealey, M. Silverberg, 1979, Clinical science.

Central Sympatholytic Drugs

K. Kario, W. Vongpatanasin, S. Atlas, 2011, Journal of clinical hypertension.